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Sequential Molecular Changes during Multistage Pathogenesis of Small Peripheral Adenocarcinomas of the Lung

Sequential Molecular Changes during Multistage Pathogenesis of Small Peripheral Adenocarcinomas... ORIGINAL ARTICLE Sequential Molecular Changes during Multistage Pathogenesis of Small Peripheral Adenocarcinomas of the Lung Junichi Soh, MD,* Shinichi Toyooka, MD,* Shuji Ichihara, MD,* Hiroaki Asano, MD,* Naruyuki Kobayashi, MD,* Hiroshi Suehisa, MD,* Hiroki Otani, MD,* Hiromasa Yamamoto, MD,* Kouichi Ichimura, MD,† Katsuyuki Kiura, MD,‡ Adi F. Gazdar, MD,§ and Hiroshi Date, MD* denocarcinomas of the lung represent a heterogeneous Introduction: We investigated EGFR and KRAS alterations among Agroup of tumors. The major subtypes identified by the atypical adenomatous hyperplasia and small lung adenocarcinomas World Health Organization (WHO) consist of bronchioloalveo- with bronchioloalveolar features to understand their role during 1,2 lar carcinoma (BAC), acinar, papillary, or solid with mucin. multistage pathogenesis. However, the majority of tumors consist of mixtures of two or Methods: Sixty lesions measuring 2 cm or less were studied, more subtypes. BAC is defined as a noninvasive tumor that has including 38 noninvasive lesions (4 atypical adenomatous hyperpla- lepidic spread, i.e., replacement of the bronchiolar or alveolar sias, 19 Noguchi type A and 15 type B) and 22 invasive lesions (type epithelium by tumor cells. The WHO also recognized a periph- C) based on the World Health Organization classification and eral lesion, atypical adenomatous hyperplasia (AAH), http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Sequential Molecular Changes during Multistage Pathogenesis of Small Peripheral Adenocarcinomas of the Lung

Date, Hiroshi
Journal of Thoracic Oncology , Volume 3 (4) – Apr 1, 2008
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ISSN
1556-0864
DOI
10.1097/JTO.0b013e318168d20a
pmid
18379350
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Sequential Molecular Changes during Multistage Pathogenesis of Small Peripheral Adenocarcinomas of the Lung Junichi Soh, MD,* Shinichi Toyooka, MD,* Shuji Ichihara, MD,* Hiroaki Asano, MD,* Naruyuki Kobayashi, MD,* Hiroshi Suehisa, MD,* Hiroki Otani, MD,* Hiromasa Yamamoto, MD,* Kouichi Ichimura, MD,† Katsuyuki Kiura, MD,‡ Adi F. Gazdar, MD,§ and Hiroshi Date, MD* denocarcinomas of the lung represent a heterogeneous Introduction: We investigated EGFR and KRAS alterations among Agroup of tumors. The major subtypes identified by the atypical adenomatous hyperplasia and small lung adenocarcinomas World Health Organization (WHO) consist of bronchioloalveo- with bronchioloalveolar features to understand their role during 1,2 lar carcinoma (BAC), acinar, papillary, or solid with mucin. multistage pathogenesis. However, the majority of tumors consist of mixtures of two or Methods: Sixty lesions measuring 2 cm or less were studied, more subtypes. BAC is defined as a noninvasive tumor that has including 38 noninvasive lesions (4 atypical adenomatous hyperpla- lepidic spread, i.e., replacement of the bronchiolar or alveolar sias, 19 Noguchi type A and 15 type B) and 22 invasive lesions (type epithelium by tumor cells. The WHO also recognized a periph- C) based on the World Health Organization classification and eral lesion, atypical adenomatous hyperplasia (AAH),

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Apr 1, 2008

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