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References (161)
-
J. Lyons, H. Uno, P. Ancuța, A. Kamat, D. Moore, E. Singer, S. Morgello, D. Gabuzda (2011)
Plasma sCD14 Is a Biomarker Associated With Impaired Neurocognitive Test Performance in Attention and Learning Domains in HIV InfectionJAIDS Journal of Acquired Immune Deficiency Syndromes, 57
-
Bennett Childs, Martina Gluscevic, D. Baker, Rémi-Martin Laberge, D. Marquess, J. Dananberg, J. Deursen (2017)
Senescent cells: an emerging target for diseases of ageingNature Reviews Drug Discovery, 16
-
A. Moulignier, J. Savatovsky, L. Assoumou, F. Lescure, C. Lamirel, O. Godin, N. Valin, R. Tubiana, A. Canestri, P. Roux, J. Sadik, L. Salomon, M. Abrivard, C. Katlama, Y. Yazdanpanah, G. Pialoux, P. Girard, D. Costagliola, Microvascular Retina, A. Moulignier, C. Amiel, L. Assoumou, A. Canestri, I. Cochereau, J. Capeau, D. Costagliola, O. Godin, P. Girard, C. Katlama, C. Lamirel, F. Lescure, L. Marchand, M. Mazighi, M. Obadia, M. Pâques, G. Pialoux, E. Plaisier, R. Tubiana, N. Valin, Y. Yazdanpanah, P. Yeni, M. Abrivard, A. Alonso, P. Koskas, L. Lopes, P. Roux, J. Sadik, L. Salomon, J. Savatovsky, Vasseur, M. Chansombat, R. Landman, B. Phung, D. Rahli, L. Lenclume, M. Valantin, J. Meynard, M. Sébire, A. Liévin, J. Bastard, S. Fellahi, M. Lebrette, P. Thibaut, G. Santos, P. Girard, J. Vincensini (2018)
Silent Cerebral Small-Vessel Disease Is Twice as Prevalent in Middle-Aged Individuals With Well-Controlled, Combination Antiretroviral Therapy–Treated Human Immunodeficiency Virus (HIV) Than in HIV-Uninfected IndividualsClinical Infectious Diseases, 66
-
I. Sereti, S. Krebs, N. Phanuphak, J. Fletcher, B. Slike, S. Pinyakorn, R. O’Connell, Adam Rupert, N. Chomont, V. Valcour, Jerome Kim, M. Robb, N. Michael, D. Douek, J. Ananworanich, N. Utay (2017)
Persistent, Albeit Reduced, Chronic Inflammation in Persons Starting Antiretroviral Therapy in Acute HIV InfectionClinical Infectious Diseases, 64
-
D. Piggott, R. Varadhan, S. Mehta, T. Brown, Huifen Li, J. Walston, S. Leng, G. Kirk (2015)
Frailty, Inflammation, and Mortality Among Persons Aging With HIV Infection and Injection Drug Use.The journals of gerontology. Series A, Biological sciences and medical sciences, 70 12
-
Seema Desai, A. Landay (2018)
HIV and aging: role of the microbiomeCurrent Opinion in HIV and AIDS, 13
-
M. Dubé, L. Komarow, C. Fichtenbaum, J. Cadden, E. Overton, H. Hodis, J. Currier, J. Stein (2015)
Extended-Release Niacin Versus Fenofibrate in HIV-Infected Participants With Low High-Density Lipoprotein Cholesterol: Effects on Endothelial Function, Lipoproteins, and Inflammation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 61 5
-
H. Taylor, Nina Calantone, R. D’Aquila (2018)
mTOR signaling mediates effects of common gamma-chain cytokines on T cell proliferation and exhaustion: implications for HIV-1 persistence and cure researchAIDS, 32
-
E. Papasavvas, L. Azzoni, Xiangfan Yin, Qin Liu, Jocelin Joseph, Agnieszka Mackiewicz, Brian Ross, K. Lynn, Jeffrey Jacobson, K. Mounzer, J. Kostman, L. Montaner (2017)
HCV viraemia associates with NK cell activation and dysfunction in antiretroviral therapy‐treated HIV/HCV‐co‐infected subjectsJournal of Viral Hepatitis, 24
-
L. Hickson, Larissa Prata, Shane Bobart, Tamara Evans, N. Giorgadze, Shahrukh Hashmi, S. Herrmann, M. Jensen, Qingyi Jia, Kyra Jordan, T. Kellogg, S. Khosla, D. Koerber, A. Lagnado, Donna Lawson, N. LeBrasseur, L. Lerman, Kathleen McDonald, T. Mckenzie, J. Passos, R. Pignolo, T. Pirtskhalava, Ishran Saadiq, Kalli Schaefer, S. Textor, Stella Victorelli, Tammie Volkman, A. Xue, M. Wentworth, Erin Gerdes, Yi Zhu, T. Tchkonia, J. Kirkland (2019)
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney diseaseEBioMedicine, 47
-
Edgar Simard, M. Shiels, K. Bhatia, E. Engels (2011)
Long-term Cancer Risk among People Diagnosed with AIDS during ChildhoodCancer Epidemiology, Biomarkers & Prevention, 21
-
U. Nogueira-Recalde, I. Lorenzo-Gómez, F. Blanco, M. Loza, D. Grassi, V. Shirinsky, I. Shirinsky, M. Lotz, P. Robbins, E. Domínguez, B. Caramés (2019)
Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapyEBioMedicine, 45
-
J. Margolick, J. Bream, Tricia Nilles, Huifen Li, Susan Langan, Shan Deng, Ruibin Wang, N. Wada, S. Leng (2018)
Relationship Between T-Cell Responses to CMV, Markers of Inflammation, and Frailty in HIV-uninfected and HIV-infected Men in the Multicenter AIDS Cohort StudyThe Journal of Infectious Diseases, 218
-
K. Futosi, T. Németh, R. Pick, T. Vántus, B. Walzog, A. Mócsai (2012)
Dasatinib inhibits proinflammatory functions of mature human neutrophilsBlood, 119
-
Yi Yang, Xiaokang Liu, Ting Wu, Wenping Zhang, J. Shu, Yulong He, Shao-Jun Tang (2018)
Quercetin attenuates AZT-induced neuroinflammation in the CNSScientific Reports, 8
-
A. Donato, Iratxe Eskurza, A. Silver, A. Levy, G. Pierce, P. Gates, D. Seals (2007)
Direct Evidence of Endothelial Oxidative Stress With Aging in Humans: Relation to Impaired Endothelium-Dependent Dilation and Upregulation of Nuclear Factor-&kgr;BCirculation Research, 100
-
K. Gianesin, A. Noguera-Julian, M. Zanchetta, P. Bianco, M. Petrara, R. Freguja, O. Rampon, C. Fortuny, M. Camós, E. Mozzo, C. Giaquinto, A. Rossi (2016)
Premature aging and immune senescence in HIV-infected childrenAIDS (London, England), 30
-
J. Glass, H. Fedor, S. Wesselingh, J. McArthur (1995)
Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementiaAnnals of Neurology, 38
-
Jean-Philippe Coppé, P. Desprez, A. Krtolica, J. Campisi (2010)
The senescence-associated secretory phenotype: the dark side of tumor suppression.Annual review of pathology, 5
-
J. Nelson, J. Krishnamurthy, P. Menezes, Yan Liu, M. Hudgens, N. Sharpless, J. Eron (2012)
Expression of p16INK4a as a biomarker of T‐cell aging in HIV‐infected patients prior to and during antiretroviral therapyAging Cell, 11
-
Michelle Wong, A. Jaworowski, A. Hearps (2019)
The HIV Reservoir in Monocytes and MacrophagesFrontiers in Immunology, 10
-
Heather Grome, L. Barnett, Cindy Hagar, D. Harrison, S. Kalams, J. Koethe (2016)
Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV.AIDS research and human retroviruses, 33 2
-
Jianhui Chang, Yingying Wang, Lijian Shao, Rémi-Martin Laberge, M. Demaria, J. Campisi, Krishnamurthy Janakiraman, N. Sharpless, Sheng Ding, W. Feng, Yiwen Luo, Xiaoyan Wang, N. Aykin-Burns, K. Krager, U. Ponnappan, M. Hauer-Jensen, A. Meng, Daohong Zhou (2015)
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in miceNature Medicine, 22
-
W. Haile, C. Gavegnano, Sijia Tao, Yong Jiang, R. Schinazi, W. Tyor (2016)
The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine modelNeurobiology of Disease, 92
-
J. Mannick, G. Giudice, M. Lattanzi, N. Valiante, J. Praestgaard, Baisong Huang, M. Lonetto, H. Maecker, J. Kovarik, S. Carson, D. Glass, L. Klickstein (2014)
mTOR inhibition improves immune function in the elderlyScience Translational Medicine, 6
-
B. O'Keeffe, Y. Fong, D. Chen, S. Zhou, Q. Zhou (2000)
Requirement for a Kinase-specific Chaperone Pathway in the Production of a Cdk9/Cyclin T1 Heterodimer Responsible for P-TEFb-mediated Tat Stimulation of HIV-1 Transcription*The Journal of Biological Chemistry, 275
-
A. Kovacs, L. Al-Harthi, Shawna Christensen, W. Mack, Mardge Cohen, A. Landay (2008)
CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus.The Journal of infectious diseases, 197 10
-
C. Sabin, S. Worm, R. Weber, P. Reiss, W. El-Sadr, F. Dabis, S. Wit, M. Law, A. Monforte, N. Friis‐Møller, O. Kirk, C. Pradier, I. Weller, A. Phillips, J. Lundgren (2008)
Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaborationThe Lancet, 371
-
D. Vaux, S. Cory, Jerry Adams (1988)
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cellsNature, 335
-
Robert Kaplan, E. Sinclair, A. Landay, N. Lurain, A. Sharrett, S. Gange, X. Xue, P. Hunt, R. Karim, David Kern, H. Hodis, S. Deeks (2011)
T Cell Activation and Senescence Predict Subclinical Carotid Artery Disease in HIV-Infected WomenThe Journal of Infectious Diseases, 203
-
D. Harrison, R. Strong, Z. Sharp, James Nelson, C. Astle, K. Flurkey, N. Nadon, J. Wilkinson, K. Frenkel, C. Carter, C. Carter, M. Pahor, M. Pahor, M. Javors, Elizabeth Fernandez, Richard Miller (2009)
Rapamycin fed late in life extends lifespan in genetically heterogeneous miceNature, 460
-
M. Pollak, N. Sonenberg (2009)
This material is the copyright of the original publisher. Unauthorised copying and distribution is prohibited. Current Status and Challenges Associated with Targeting mTOR for Cancer Therapy -
Christopher Miller, J. Baker, A. Bormann, Kristine Erlandson, K. Hullsiek, A. Justice, Jacqueline Neuhaus, R. Paredes, K. Petoumenos, D. Wentworth, A. Winston, J. Wolfson, J. Neaton (2014)
Adjudicated Morbidity and Mortality Outcomes by Age among Individuals with HIV Infection on Suppressive Antiretroviral TherapyPLoS ONE, 9
-
K. Mcculloch, G. Litherland, T. Rai (2017)
Cellular senescence in osteoarthritis pathologyAging Cell, 16
-
R. Heaton, D. Franklin, R. Ellis, J. McCutchan, S. Letendre, S. LeBlanc, S. Corkran, N. Duarte, D. Clifford, S. Woods, A. Collier, C. Marra, S. Morgello, M. Mindt, Michael Taylor, T. Marcotte, J. Atkinson, T. Wolfson, B. Gelman, J. McArthur, D. Simpson, I. Abramson, A. Gamst, C. Fennema-Notestine, T. Jernigan, J. Wong, I. Grant, for Groups (2010)
HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictorsJournal of Neurovirology, 17
-
E. Losina, E. Hyle, E. Borre, B. Linas, P. Sax, M. Weinstein, Corinna Rusu, A. Ciaranello, R. Walensky, K. Freedberg (2017)
Projecting 10-year, 20-year, and Lifetime Risks of Cardiovascular Disease in Persons Living With Human Immunodeficiency Virus in the United StatesClinical Infectious Diseases, 65
-
E. Mills, T. Bärnighausen, J. Negin (2012)
HIV and aging--preparing for the challenges ahead.The New England journal of medicine, 366 14
-
S. Plaeger, Brenda Collins, R. Musib, S. Deeks, Sarah Read, A. Embry (2011)
Immune activation in the pathogenesis of treated chronic HIV disease: a workshop summary.AIDS research and human retroviruses, 28 5
-
Jinliang Li, J. Das, Pingtao Tang, Zhe Han, J. Jaiswal, P. Ray (2017)
Transmembrane TNF-α Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy.Journal of the American Society of Nephrology : JASN, 28 3
-
Stefanie Kroeze, F. Wit, T. Rossouw, H. Steel, C. Kityo, M. Siwale, S. Akanmu, K. Mandaliya, Marleen Jager, P. Ondoa, P. Reiss, T. Wit, N. Kootstra, R. Hamers (2019)
Plasma Biomarkers of Human Immunodeficiency Virus–Related Systemic Inflammation and Immune Activation in Sub-Saharan Africa Before and During Suppressive Antiretroviral TherapyThe Journal of Infectious Diseases, 220
-
L. Samaraweera, Alfred Adomako, A. Rodriguez-Gabin, H. McDaid (2017)
A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCCScientific Reports, 7
-
D. Ehninger, F. Neff, Kan Xie (2014)
Longevity, aging and rapamycinCellular and Molecular Life Sciences, 71
-
T. Kuilman, C. Michaloglou, Liesbeth Vredeveld, Sirith Douma, R. Doorn, C. Desmet, L. Aarden, W. Mooi, D. Peeper (2008)
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory NetworkCell, 133
-
Sophie Cohen, J. Stege, G. Geurtsen, H. Scherpbier, T. Kuijpers, P. Reiss, B. Schmand, D. Pajkrt (2015)
Poorer cognitive performance in perinatally HIV-infected children versus healthy socioeconomically matched controls.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60 7
-
Ming Xu, T. Tchkonia, H. Ding, M. Ogrodnik, Ellen Lubbers, T. Pirtskhalava, T. White, Kurt Johnson, Michael Stout, V. Mezera, N. Giorgadze, M. Jensen, N. LeBrasseur, J. Kirkland (2015)
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old ageProceedings of the National Academy of Sciences, 112
-
M. Schafer, T. White, K. Iijima, A. Haak, G. Ligresti, E. Atkinson, A. Oberg, J. Birch, Hanna Salmonowicz, Yi Zhu, Daniel Mazula, R. Brooks, Heike Fuhrmann-Stroissnigg, T. Pirtskhalava, Y. Prakash, T. Tchkonia, P. Robbins, M. Aubry, J. Passos, J. Kirkland, D. Tschumperlin, H. Kita, N. LeBrasseur (2017)
Cellular senescence mediates fibrotic pulmonary diseaseNature Communications, 8
-
J. Justice, A. Nambiar, T. Tchkonia, N. LeBrasseur, R. Pascual, S. Hashmi, L. Prata, M. Masternak, S. Kritchevsky, N. Musi, J. Kirkland (2019)
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot studyEBioMedicine, 40
-
H. Delagreverie, C. Delaugerre, S. Lewin, S. Deeks, Jonathan Li (2016)
Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory AgentsOpen Forum Infectious Diseases, 3
-
D. Ho, Rota Tr, M. Hirsch (1986)
Infection of monocyte/macrophages by human T lymphotropic virus type III.The Journal of clinical investigation, 77 5
-
K. High, M. Brennan-Ing, D. Clifford, Mardge Cohen, J. Currier, S. Deeks, S. Deren, R. Effros, K. Gebo, J. Goronzy, A. Justice, A. Landay, J. Levin, P. Miotti, R. Munk, Heidi Nass, C. Rinaldo, M. Shlipak, R. Tracy, V. Valcour, D. Vance, J. Walston, P. Volberding (2012)
HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working GroupJAIDS Journal of Acquired Immune Deficiency Syndromes, 60
-
Jerry Adams, S. Cory (2018)
The BCL-2 arbiters of apoptosis and their growing role as cancer targets.Cell death and differentiation, 25 1
-
A. Spivak, V. Planelles (2016)
HIV-1 Eradication: Early Trials (and Tribulations).Trends in molecular medicine, 22 1
-
J. Tilstra, A. Robinson, Jin Wang, Siobhán Gregg, Cheryl Clauson, D. Reay, L. Nasto, C. Croix, A. Ūsas, N. Vo, J. Huard, P. Clemens, D. Stolz, D. Guttridge, Simon Watkins, G. Garinis, Yinsheng Wang, L. Niedernhofer, P. Robbins (2012)
NF-κB inhibition delays DNA damage-induced senescence and aging in mice.The Journal of clinical investigation, 122 7
-
Swenja Kröller-Schön, T. Jansen, Andrea Schüler, M. Oelze, P. Wenzel, M. Hausding, Jasmin Kerahrodi, Maike Beisele, K. Lackner, A. Daiber, T. Münzel, Eberhard Schulz (2013)
Peroxisome Proliferator-activated Receptor &ggr;, Coactivator 1&agr; Deletion Induces Angiotensin II–Associated Vascular Dysfunction by Increasing Mitochondrial Oxidative Stress and Vascular InflammationArteriosclerosis, Thrombosis, and Vascular Biology, 33
-
S. Simioni, M. Cavassini, J. Annoni, Aline Abraham, I. Bourquin, V. Schiffer, A. Calmy, J. Chave, E. Giacobini, B. Hirschel, R. Pasquier (2009)
Cognitive dysfunction in HIV patients despite long-standing suppression of viremiaAIDS, 24
-
I. Tabas, A. Lichtman (2017)
Monocyte-Macrophages and T Cells in Atherosclerosis.Immunity, 47 4
-
P. Richardson, J. Laubach, S. Lonial, P. Moreau, S. Yoon, V. Hungria, M. Dimopoulos, M. Beksaç, M. Alsina, J. San-Miguel (2015)
Panobinostat: a novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myelomaExpert Review of Anticancer Therapy, 15
-
E. Falcinelli, D. Francisci, B. Belfiori, E. Petito, G. Guglielmini, L. Malincarne, A. Mezzasoma, M. Sebastiano, V. Conti, S. Giannini, S. Bonora, F. Baldelli, P. Gresele (2013)
In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patientsThrombosis and Haemostasis, 110
-
S. Boekholdt, Ron Peters, C. Hack, Nicholas Day, R. Luben, Sheila Bingham, N. Wareham, P. Reitsma, K. Khaw (2004)
IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women: The EPIC-Norfolk Prospective Population StudyArteriosclerosis, Thrombosis, and Vascular Biology, 24
-
E. Besnard, E. Besnard, S. Hakre, S. Hakre, M. Kampmann, H. Lim, H. Lim, Nina Hosmane, Alyssa Martin, M. Bassik, E. Verschueren, E. Battivelli, E. Battivelli, J. Chan, J. Chan, J. Svensson, A. Gramatica, A. Gramatica, Ryan Conrad, Ryan Conrad, M. Ott, M. Ott, W. Greene, W. Greene, N. Krogan, N. Krogan, R. Siliciano, J. Weissman, E. Verdin, E. Verdin (2016)
The mTOR Complex Controls HIV Latency.Cell host & microbe, 20 6
-
Richard Moore, J. Keruly (2007)
CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 44 3
-
Joungmok Kim, K. Guan (2019)
mTOR as a central hub of nutrient signalling and cell growthNature Cell Biology, 21
-
Á. Álvarez, Samuel Orden, I. Andújar, V. Collado-Díaz, Sara Núñez-Delgado, M. Galindo, V. Estrada, N. Apostolova, J. Esplugues (2017)
Cardiovascular toxicity of abacavir: a clinical controversy in need of a pharmacological explanationAIDS, 31
-
D. Baker, Tobias Wijshake, T. Tchkonia, N. LeBrasseur, Bennett Childs, B. Sluis, J. Kirkland, J. Deursen (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disordersNature, 479
-
D. Clifford, B. Ances (2013)
HIV-associated neurocognitive disorder.The Lancet. Infectious diseases, 13 11
-
L. Loomba-Albrecht, T. Bregman, C. Chantry (2014)
Endocrinopathies in children infected with human immunodeficiency virus.Endocrinology and metabolism clinics of North America, 43 3
-
E. Lakatta, D. Levy (2003)
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease.Circulation, 107 1
-
W. Hang, Z. Yin, Gang Liu, Qinghua Zeng, Xiangfeng Shen, Qian-Hui Sun, Dong-Dong Li, Yong-Ping Jian, Yanghe Zhang, Yishu Wang, Cheng-shi Quan, Rui-Xun Zhao, Yu-lin Li, Zhi-xiang Xu (2018)
Piperlongumine and p53-Reactivator APR-246 Selectively Induce Cell Death in HNSCC by Targeting GSTP1Oncogene, 37
-
R. Nabatanzi, L. Bayigga, S. Cose, S. Jones, M. Joloba, Glenda Canderan, D. Nakanjako (2019)
Monocyte Dysfunction, Activation, and Inflammation After Long-Term Antiretroviral Therapy in an African CohortThe Journal of Infectious Diseases, 220
-
J. Currier, Anne Taylor, Felicity Boyd, C. Dezii, H. Kawabata, Beth Burtcel, J. Maa, S. Hodder (2003)
Coronary heart disease in HIV-infected individuals.Journal of acquired immune deficiency syndromes, 33 4
-
F. Rönsholt, H. Ullum, T. Katzenstein, J. Gerstoft, S. Ostrowski (2013)
Persistent Inflammation and Endothelial Activation in HIV-1 Infected Patients after 12 Years of Antiretroviral TherapyPLoS ONE, 8
-
P. Stock, B. Barin, H. Hatano, Rodney Rogers, M. Roland, Tzong-Hae Lee, M. Busch, S. Deeks (2014)
Reduction of HIV Persistence Following Transplantation in HIV‐Infected Kidney Transplant RecipientsAmerican Journal of Transplantation, 14
-
A. Silva, RF Magalhães, VC Branco, J.D. Silva, F. Cruz, P. Marques, T. Ferreira, M. Morales, M. Martins, PC Olsen, P. Rocco (2016)
The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthmaBritish Journal of Pharmacology, 173
-
G. Ulfhammer, A. Edén, Å. Mellgren, D. Fuchs, H. Zetterberg, L. Hagberg, S. Nilsson, A. Yilmaz, M. Gisslén (2018)
Persistent central nervous system immune activation following more than 10 years of effective HIV antiretroviral treatmentAIDS, 32
-
A. Morou, E. Brunet-Ratnasingham, M. Dubé, Roxanne Charlebois, Eloi Mercier, S. Darko, N. Brassard, Krystelle Nganou-Makamdop, Sahaana Arumugam, G. Gendron-Lepage, Lifei Yang, J. Niessl, A. Baxter, J. Billingsley, P. Rajakumar, F. Lefebvre, R. Johnson, C. Tremblay, J. Routy, R. Wyatt, A. Finzi, D. Douek, D. Kaufmann (2019)
Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive diseaseNature immunology, 20
-
J. Kirkland, T. Tchkonia (2017)
Cellular Senescence: A Translational PerspectiveEBioMedicine, 21
-
Carolyn Roos, Bin Zhang, Allyson Palmer, M. Ogrodnik, T. Pirtskhalava, Nassir Thalji, Michael Hagler, D. Jurk, Leslie Smith, Grace Casaclang-Verzosa, Yi Zhu, M. Schafer, T. Tchkonia, J. Kirkland, Jordan Miller (2016)
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic miceAging Cell, 15
-
A. Young, M. Narita (2009)
SASP reflects senescenceEMBO reports, 10
-
Jennifer Campbell, A. Hearps, G. Martin, K. Williams, S. Crowe (2014)
The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cureAIDS, 28
-
I.Maeve Rea, David Gibson, V. Mcgilligan, S. Mcnerlan, H. Alexander, Owen Ross (2018)
Age and Age-Related Diseases: Role of Inflammation Triggers and CytokinesFrontiers in Immunology, 9
-
C. Gavegnano, J. Brehm, F. Dupuy, A. Talla, S. Ribeiro, D. Kulpa, C. Cameron, S. Santos, S. Hurwitz, V. Marconi, J. Routy, L. Sabbagh, R. Schinazi, R. Sékaly (2017)
Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitorsPLoS Pathogens, 13
-
V. Jain, W. Hartogensis, P. Bacchetti, P. Hunt, H. Hatano, E. Sinclair, L. Epling, Tzong-Hae Lee, M. Busch, J. McCune, C. Pilcher, F. Hecht, S. Deeks (2013)
Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size.The Journal of infectious diseases, 208 8
-
J. Brenchley, D. Price, T. Schacker, Tedi Asher, G. Silvestri, Srinivas Rao, Zachary Kazzaz, E. Bornstein, O. Lambotte, D. Altmann, B. Blazar, B. Rodriguez, L. Teixeira-Johnson, A. Landay, Jeffrey Martin, F. Hecht, L. Picker, M. Lederman, S. Deeks, D. Douek (2006)
Microbial translocation is a cause of systemic immune activation in chronic HIV infectionNature Medicine, 12
-
Yun-Ui Bae, Youlim Son, Chang-Hyun Kim, Kwang Kim, Se-Hee Hyun, H. Woo, Byul Jee, Jun-Hyuk Choi, H. Sung, H. Choi, S. Park, J. Bae, K. Doh, Jae-Ryong Kim (2018)
Embryonic stem cell-derived mmu-miR-291a-3p inhibits cellular senescence in human dermal fibroblasts through the TGF--receptor 2 pathway.The journals of gerontology. Series A, Biological sciences and medical sciences
-
T. Booiman, F. Wit, I. Maurer, D. Francesco, C. Sabin, A. Harskamp, M. Prins, P. Garagnani, C. Pirazzini, C. Franceschi, D. Fuchs, M. Gisslén, A. Winston, P. Reiss, N. Kootstra, P. Janssen, P. Reiss, F. Wit, J. Schouten, K. Kooij, R. Zoest, B. Elsenga, F. Janssen, M. Heidenrijk, W. Zikkenheiner, M. Valk, N. Kootstra, T. Booiman, A. Harskamp-Holwerda, B. Boeser-Nunnink, I. Maurer, M. Ruiz, A. Girigorie, J. Villaudy, E. Frankin, A. Pasternak, B. Berkhout, T. Kuyl, P. Portegies, B. Schmand, G. Geurtsen, J. Stege, M. Twennaar, C. Majoie, M. Caan, T. Su, K. Weijer, P. Bisschop, A. Kalsbeek, M. Wezel, I. Visser, H. Ruhé, C. Franceschi, P. Garagnani, C. Pirazzini, M. Capri, F. dall’Olio, M. Chiricolo, S. Salvioli, J. Hoeijmakers, J. Pothof, M. Prins, M. Martens, S. Moll, J. Berkel, M. Totte, S. Kovalev, M. Gisslén, D. Fuchs, H. Zetterberg, A. Winston, J. Underwood, L. Mcdonald, M. Stott, K. Legg, A. Lovell, O. Erlwein, N. Doyle, C. Kingsley, D. Sharp, R. Leech, J. Cole, S. Zaheri, M. Hillebregt, Y. Ruijs, D. Benschop, D. Burger, M. Graaff-Teulen, G. Guaraldi, A. Bürkle, T. Sindlinger, M. Moreno-Villanueva, A. Keller, C. Sabin, D. Francesco, C. Libert, S. Dewaele (2017)
High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal FluidOpen Forum Infectious Diseases, 4
-
M. Freiberg, C. Chang, L. Kuller, M. Skanderson, Elliott Lowy, K. Kraemer, A. Butt, M. Goetz, D. Leaf, K. Oursler, D. Rimland, M. Barradas, Sheldon Brown, C. Gibert, K. McGinnis, K. Crothers, J. Sico, H. Crane, A. Warner, S. Gottlieb, J. Gottdiener, R. Tracy, M. Budoff, C. Watson, K. Armah, D. Doebler, K. Bryant, A. Justice (2013)
HIV infection and the risk of acute myocardial infarction.JAMA internal medicine, 173 8
-
A. Donato, Alexander Black, K. Jablonski, L. Gano, D. Seals (2008)
Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humansAging Cell, 7
-
A. Schade, G. Schieven, R. Townsend, A. Jankowska, Vojkan Susulic, Rosemary Zhang, H. Szpurka, J. Maciejewski (2008)
Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation.Blood, 111 3
-
C. Sabin, P. Reiss, L. Ryom, A. Phillips, R. Weber, M. Law, E. Fontas, A. Mocroft, S. Wit, Colette Smith, F. Dabis, A. Monforte, W. El-Sadr, J. Lundgren (2016)
Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaborationBMC Medicine, 14
-
T. Puthanakit, L. Aurpibul, O. Louthrenoo, Pimmas Tapanya, R. Nadsasarn, S. Insee-ard, V. Sirisanthana (2010)
Poor cognitive functioning of school-aged children in thailand with perinatally acquired HIV infection taking antiretroviral therapy.AIDS patient care and STDs, 24 3
-
M. Bermejo, M. López-Huertas, J. García-Pérez, N. Climent, B. Descours, J. Ambrosioni, E. Mateos, S. Rodríguez-Mora, Lucía Rus-Bercial, M. Benkirane, J. Miró, M. Plana, J. Alcamí, M. Coiras (2016)
Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells.Biochemical pharmacology, 106
-
Jamison Norwood, M. Turner, Carmen Bofill, Peter Rebeiro, B. Shepherd, Sally Bebawy, T. Hulgan, S. Raffanti, D. Haas, T. Sterling, J. Koethe (2017)
Brief Report: Weight Gain in Persons With HIV Switched From Efavirenz-Based to Integrase Strand Transfer Inhibitor–Based RegimensJAIDS Journal of Acquired Immune Deficiency Syndromes, 76
-
Matthew Yousefzadeh, Yi Zhu, S. McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Y. Ling, Kendra Melos, T. Pirtskhalava, C. Inman, Collin McGuckian, Erin Wade, J. Kato, D. Grassi, M. Wentworth, C. Burd, E. Arriaga, Warren Ladiges, T. Tchkonia, J. Kirkland, P. Robbins, L. Niedernhofer (2018)
Fisetin is a senotherapeutic that extends health and lifespanEBioMedicine, 36
-
C. Tincati, E. Merlini, P. Braidotti, G. Ancona, Federica Savi, D. Tosi, E. Borghi, M. Callegari, B. Mangiavillano, A. Barassi, G. Bulfamante, A. Monforte, S. Romagnoli, N. Chomont, G. Marchetti (2016)
Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+ T-cell recovery upon virologically suppressive combination antiretroviral therapyAIDS, 30
-
J. Rubio-Pérez, J. Morillas-Ruiz (2012)
A Review: Inflammatory Process in Alzheimer's Disease, Role of CytokinesThe Scientific World Journal, 2012
-
L. Leite, A. Cohen, F. Boccara (2017)
HIV infection and aortic stiffness.Archives of cardiovascular diseases, 110 8-9
-
R. Bhat, E. Crowe, Alessandro Bitto, Michelle Moh, C. Katsetos, F. Garcia, F. Johnson, J. Trojanowski, C. Sell, C. Torres (2012)
Astrocyte Senescence as a Component of Alzheimer’s DiseasePLoS ONE, 7
-
J. McArthur, D. Mcclernon, M. Cronin, T. Nance-Sproson, A. Saah, M. Clair, E. Lanier (1997)
Relationship between human immunodeficiency virus—associated dementia and viral load in cerebrospinal fluid and brainAnnals of Neurology, 42
-
Tyler Bussian, Asef Aziz, Charlton Meyer, Barbara Swenson, J. Deursen, D. Baker (2018)
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive declineNature, 562
-
L. Niedernhofer, P. Robbins (2018)
Senotherapeutics for healthy ageingNature Reviews Drug Discovery, 17
-
Yi Zhu, T. Tchkonia, T. Pirtskhalava, A. Gower, H. Ding, N. Giorgadze, Allyson Palmer, Y. Ikeno, G. Hubbard, M. Lenburg, S. O’Hara, N. LaRusso, Jordan Miller, Carolyn Roos, Grace Verzosa, N. LeBrasseur, J. Wren, J. Farr, S. Khosla, Michael Stout, S. McGowan, Heike Fuhrmann-Stroissnigg, Aditi Gurkar, J. Zhao, D. Colangelo, A. Dorronsoro, Y. Ling, Amira Barghouthy, D. Navarro, T. Sano, P. Robbins, L. Niedernhofer, J. Kirkland (2015)
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugsAging Cell, 14
-
F. Palella, K. Delaney, A. Moorman, M. Loveless, J. Fuhrer, G. Satten, D. Aschman, S. Holmberg (1998)
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.The New England journal of medicine, 338 13
-
E. Suzuki, Masao Takahashi, S. Oba, H. Nishimatsu (2013)
Oncogene- and Oxidative Stress-Induced Cellular Senescence Shows Distinct Expression Patterns of Proinflammatory Cytokines in Vascular Endothelial CellsThe Scientific World Journal, 2013
-
Shu-guang Gao, C. Zeng, Liang-jun Li, W. Luo, Fangjie Zhang, Jian Tian, Chao Cheng, M. Tu, Yilin Xiong, Wei Jiang, Mai Xu, G. Lei (2016)
Correlation between senescence‐associated beta‐galactosidase expression in articular cartilage and disease severity of patients with knee osteoarthritisInternational Journal of Rheumatic Diseases, 19
-
P. Heidenreich, J. Trogdon, Olga Khavjou, J. Butler, K. Dracup, M. Ezekowitz, E. Finkelstein, Yuling Hong, S. Johnston, A. Khera, D. Lloyd‐Jones, Sue Nelson, G. Nichol, Diane Orenstein, P. Wilson, Y. Woo (2011)
Forecasting the Future of Cardiovascular Disease in the United States: A Policy Statement From the American Heart AssociationCirculation, 123
-
KV Shmagel, EV Saidakova, N. Shmagel, L. Korolevskaya, V. Chereshnev, J. Robinson, J. Grivel, D. Douek, L. Margolis, DD Anthony, M. Lederman (2016)
Systemic inflammation and liver damage in HIV/hepatitis C virus coinfectionHIV Medicine, 17
-
E. Cassol, S. Malfeld, P. Mahasha, R. Bond, T. Slavik, C. Seebregts, G. Poli, S. Cassol, S. Merwe, T. Rossouw (2013)
Impaired CD4+ T-cell restoration in the small versus large intestine of HIV-1-positive South Africans receiving combination antiretroviral therapy.The Journal of infectious diseases, 208 7
-
J. Ho, R. Scherzer, F. Hecht, K. Maka, Van Selby, Jeffrey Martin, P. Ganz, S. Deeks, P. Hsue (2012)
The association of CD4+ T-cell counts and cardiovascular risk in treated HIV diseaseAIDS, 26
-
N. Chen, A. Partridge, Ferit Tuzer, Justin Cohen, T. Nacarelli, S. Navas-Martín, C. Sell, C. Torres, J. Martín-García (2018)
Induction of a Senescence-Like Phenotype in Cultured Human Fetal Microglia During HIV-1 InfectionThe Journals of Gerontology: Series A, 73
-
T. Tchkonia, Yi Zhu, J. Deursen, J. Campisi, J. Kirkland (2013)
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.The Journal of clinical investigation, 123 3
-
S. Ribeiro, J. Milush, E. Cunha-Neto, E. Kallas, J. Kalil, L. Passero, P. Hunt, S. Deeks, D. Nixon, Devi SenGupta (2016)
p16INK4a Expression and Immunologic Aging in Chronic HIV InfectionPLoS ONE, 11
-
M. Egger, M. May, G. Chêne, A. Phillips, B. Ledergerber, F. Dabis, D. Costagliola, A. Monforte, F. Wolf, P. Reiss, J. Lundgren, A. Justice, S. Staszewski, C. Leport, R. Hogg, C. Sabin, J. Gill, B. Salzberger, J. Sterne (2002)
Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studiesThe Lancet, 360
-
S. Xia, Xinyan Zhang, Songbai Zheng, R. Khanabdali, B. Kalionis, Junzhen Wu, W. Wan, Xiantao Tai (2016)
An Update on Inflamm-Aging: Mechanisms, Prevention, and TreatmentJournal of Immunology Research, 2016
-
H. Duan, C. Heckman, L. Boxer (2005)
Histone Deacetylase Inhibitors Down-Regulate bcl-2 Expression and Induce Apoptosis in t(14;18) LymphomasMolecular and Cellular Biology, 25
-
R. Gandhi, D. McMahon, R. Bosch, C. Lalama, J. Cyktor, B. Macatangay, C. Rinaldo, S. Riddler, E. Hogg, C. Godfrey, A. Collier, J. Eron, J. Mellors (2017)
Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activationPLoS Pathogens, 13
-
L. Bestilny, M. Gill, C. Mody, K. Riabowol (2000)
Accelerated replicative senescence of the peripheral immune system induced by HIV infectionAIDS, 14
-
Kristine Erlandson, Jeremiah Perez, Mona Abdo, K. Robertson, R. Ellis, S. Koletar, R. Kalayjian, B. Taiwo, F. Palella, Katherine Tassiopoulos (2019)
Frailty, Neurocognitive Impairment, or Both in Predicting Poor Health Outcomes Among Adults Living With Human Immunodeficiency VirusClinical Infectious Diseases, 68
-
J. Manavalan, S. Arpadi, Shenthuraan Tharmarajah, Jayesh Shah, Chiyuan Zhang, M. Foca, N. Neu, D. Bell, K. Nishiyama, S. Kousteni, M. Yin (2016)
Abnormal Bone Acquisition With Early‐Life HIV Infection: Role of Immune Activation and Senescent Osteogenic PrecursorsJournal of Bone and Mineral Research, 31
-
N. Cummins, Amy Sainski, Haiming Dai, S. Natesampillai, Y. Pang, G. Bren, Maria Correia, R. Sampath, S. Rizza, D. O'Brien, J. Yao, S. Kaufmann, A. Badley (2016)
Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir SizeJournal of Virology, 90
-
V. Triant, Hang Lee, C. Hadigan, S. Grinspoon (2007)
Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease.The Journal of clinical endocrinology and metabolism, 92 7
-
N. Contreras, K. Sitnik, I. Jeftić, C. Coplen, L. Čičin-Šain, J. Nikolich-Žugich (2019)
Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemiaPLoS Pathogens, 15
-
M. Freeman, M. Lederman, S. Gianella (2016)
Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV InfectionCurrent HIV/AIDS Reports, 13
-
M. Fuentealba, Handan Dönertaş, Rhîannan Williams, Johnathan Labbadia, J. Thornton, L. Partridge (2018)
Using the drug-protein interactome to identify anti-ageing compounds for humansPLoS Computational Biology, 15
-
Netusha Thevaranjan, Alicja Puchta, Christian Schulz, Avee Naidoo, J. Szamosi, C. Verschoor, Dessi Loukov, L. Schenck, J. Jury, K. Foley, J. Schertzer, M. Larché, D. Davidson, E. Verdú, M. Surette, D. Bowdish (2017)
Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage DysfunctionCell Host & Microbe, 21
-
Ling Xu, Fengyan Tang, Lydia Li, XinQi Dong (2017)
Grandparent Caregiving and Psychological Well-Being Among Chinese American Older Adults—The Roles of Caregiving Burden and PressureJournals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 72
-
A. Davidson, R. Wainwright, D. Stones, M. Kruger, M. Hendricks, J. Geel, J. Poole, D. Reynders, F. Omar, R. Mathew, D. Stefan (2014)
Malignancies in South African Children With HIVJournal of Pediatric Hematology/Oncology, 36
-
Sean Kelly, Kunling Wu, Katherine Tassiopoulos, Kristine Erlandson, S. Koletar, F. Palella (2019)
Frailty is an independent risk factor for mortality, cardiovascular disease, bone disease and diabetes among aging adults with HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
-
P. Joshi, E. Maidji, C. Stoddart (2016)
Inhibition of Heat Shock Protein 90 Prevents HIV ReboundThe Journal of Biological Chemistry, 291
-
T. Rasmussen, M. Tolstrup, C. Brinkmann, R. Olesen, C. Erikstrup, A. Solomon, A. Winckelmann, S. Palmer, C. Dinarello, M. Buzón, M. Lichterfeld, S. Lewin, L. Østergaard, O. Søgaard (2014)
Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial.The lancet. HIV, 1 1
-
Alexandre Deshiere, C. Joly-Beauparlant, Yann Breton, M. Ouellet, F. Raymond, R. Lodge, C. Barat, M. Roy, J. Corbeil, M. Tremblay (2017)
Global Mapping of the Macrophage-HIV-1 Transcriptome Reveals that Productive Infection Induces Remodeling of Host Cell DNA and ChromatinScientific Reports, 7
-
R. Heaton, D. Clifford, D. Franklin, S. Woods, C. Ake, F. Vaida, R. Ellis, S. Letendre, T. Marcotte, J. Atkinson, M. Rivera-Mindt, Ofilio Vigil, Michael Taylor, A. Collier, C. Marra, B. Gelman, J. Mcarthur, S. Morgello, D. Simpson, McCutchan Ja, I. Abramson, A. Gamst, C. Fennema-Notestine, T. Jernigan, J. Wong, I. Grant (2010)
HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapyNeurology, 75
-
L. Zheng, J. Ock, B. Kwon, K. Suk (2008)
Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity.International immunopharmacology, 8 3
-
M. Baar, R. Brandt, D. Putavet, Julian Klein, K. Derks, Benjamin Bourgeois, Sarah Stryeck, Y. Rijksen, Hester Willigenburg, D. Feijtel, I. Pluijm, J. Essers, W. Cappellen, W. Ijcken, A. Houtsmuller, J. Pothof, R. Bruin, T. Madl, J. Hoeijmakers, J. Campisi, P. Keizer. (2017)
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and AgingCell, 169
-
Carol Holtzman, C. Armon, E. Tedaldi, J. Chmiel, K. Buchacz, K. Wood, J. Brooks, and Investigators (2013)
Polypharmacy and Risk of Antiretroviral Drug Interactions Among the Aging HIV-Infected PopulationJournal of General Internal Medicine, 28
-
S. Blake, T. Hughes, G. Mayrhofer, A. Lyons (2008)
The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro.Clinical immunology, 127 3
-
S. Leng, J. Margolick (2015)
Understanding Frailty, Aging, and Inflammation in HIV InfectionCurrent HIV/AIDS Reports, 12
-
A. Vallejo, C. Weyand, J. Goronzy (2004)
T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection.Trends in molecular medicine, 10 3
-
R. Karim, W. Mack, N. Kono, P. Tien, K. Anastos, J. Lazar, M. Young, Seema Desai, E. Golub, R. Kaplan, H. Hodis, A. Kovacs (2014)
T-Cell Activation, Both Pre- and Post-HAART Levels, Correlates With Carotid Artery Stiffness Over 6.5 Years Among HIV-Infected Women in the WIHSJAIDS Journal of Acquired Immune Deficiency Syndromes, 67
-
J. Deursen (2014)
The role of senescent cells in ageingNature, 509
-
J. Das, J. Gutkind, Patricio Ray (2016)
Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial CellsPLoS ONE, 11
-
S. Deeks (2011)
HIV infection, inflammation, immunosenescence, and aging.Annual review of medicine, 62
-
Seema Desai, A. Landay (2010)
Early Immune Senescence in HIV DiseaseCurrent HIV/AIDS Reports, 7
-
H. Hatano, S. Yukl, A. Ferre, E. Graf, M. Somsouk, E. Sinclair, M. Abdel-Mohsen, T. Liegler, Kara Harvill, R. Hoh, S. Palmer, P. Bacchetti, P. Hunt, Jeffrey Martin, J. McCune, R. Tracy, M. Busch, U. O’Doherty, B. Shacklett, J. Wong, S. Deeks (2013)
Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected ControllersPLoS Pathogens, 9
-
T. Rasmussen, O. Søgaard, C. Brinkmann, F. Wightman, S. Lewin, J. Melchjorsen, C. Dinarello, L. Østergaard, M. Tolstrup (2013)
Comparison of HDAC inhibitors in clinical developmentHuman Vaccines & Immunotherapeutics, 9
-
Aviva Mattingly, Aylin Unsal, Julia Purdy, A. Gharib, Adam Rupert, J. Kovacs, D. Mcareavey, R. Hazra, Khaled Abd-Elmoniem, C. Hadigan (2017)
T-cell Activation and E-selectin Are Associated With Coronary Plaque in HIV-infected Young AdultsThe Pediatric Infectious Disease Journal, 36
-
C. Gavegnano, W. Haile, S. Hurwitz, Sijia Tao, Yong Jiang, R. Schinazi, W. Tyor (2019)
Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitroJournal of Neuroinflammation, 16
-
Ming Xu, T. Pirtskhalava, J. Farr, B. Weigand, Allyson Palmer, Megan Weivoda, C. Inman, M. Ogrodnik, Christine Hachfeld, Daniel Fraser, Jennifer Onken, Kurt Johnson, Grace Verzosa, Larissa Langhi, M. Weigl, N. Giorgadze, N. LeBrasseur, Jordan Miller, D. Jurk, Ravinder Singh, D. Allison, K. Ejima, G. Hubbard, Y. Ikeno, H. Čubro, V. Garovic, X. Hou, S. Weroha, P. Robbins, L. Niedernhofer, S. Khosla, T. Tchkonia, J. Kirkland (2018)
Senolytics Improve Physical Function and Increase Lifespan in Old AgeNature medicine, 24
-
M. Varnum, T. Ikezu (2012)
The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease BrainArchivum Immunologiae et Therapiae Experimentalis, 60
-
S. Deeks, A. Phillips (2009)
HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidityBMJ : British Medical Journal, 338
-
T. Brothers, S. Kirkland, G. Guaraldi, J. Falutz, O. Theou, B. Johnston, K. Rockwood (2014)
Frailty in people aging with human immunodeficiency virus (HIV) infection.The Journal of infectious diseases, 210 8
-
J. Honeycutt, A. Wahl, Caroline Baker, Rae Spagnuolo, J. Foster, Oksana Zakharova, S. Wietgrefe, Carolina Caro-Vegas, V. Madden, G. Sharpe, A. Haase, J. Eron, J. Garcia (2016)
Macrophages sustain HIV replication in vivo independently of T cells.The Journal of clinical investigation, 126 4
-
N. Barzilai, J. Crandall, S. Kritchevsky, M. Espeland (2016)
Metformin as a Tool to Target Aging.Cell metabolism, 23 6
-
Yi Zhu, T. Tchkonia, Heike Fuhrmann-Stroissnigg, Haiming Dai, Y. Ling, Michael Stout, T. Pirtskhalava, N. Giorgadze, Kurt Johnson, Cory Giles, J. Wren, L. Niedernhofer, P. Robbins, J. Kirkland (2016)
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factorsAging Cell, 15
-
Reut Yosef, Noam Pilpel, Ronit Tokarsky-Amiel, Anat Biran, Yossi Ovadya, S. Cohen, E. Vadai, Liat Dassa, Elisheva Shahar, R. Condiotti, I. Ben-Porath, V. Krizhanovsky (2016)
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XLNature Communications, 7
-
G. Janssens, Xin-Xuan Lin, L. Millan-Ariño, Alan Kavšek, Ilke Sen, Renée Seinstra, Nicholas Stroustrup, E. Nollen, C. Riedel (2018)
Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer AgingCell Reports, 27
-
H. Kang, Joon-Tae Park, Kobong Choi, Yongsub Kim, Hyo Choi, C. Jung, Young-Sam Lee, S. Park (2017)
Chemical screening identifies ATM as a target for alleviating senescence.Nature chemical biology, 13 6
-
Ivana Ferrer, M. Wagener, J. Robertson, A. Turner, K. Araki, R. Ahmed, A. Kirk, C. Larsen, M. Ford (2010)
Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell ResponsesThe Journal of Immunology, 185
-
Anne Kjær, C. Brinkmann, C. Dinarello, R. Olesen, L. Østergaard, O. Søgaard, M. Tolstrup, T. Rasmussen (2015)
The histone deacetylase inhibitor panobinostat lowers biomarkers of cardiovascular risk and inflammation in HIV patientsAIDS, 29
-
Alejandro Martín-Montalvo, E. Mercken, S. Mitchell, Hector Palacios, P. Mote, M. Scheibye-Knudsen, A. Gomes, Theresa Ward, R. Minor, M. Blouin, M. Schwab, M. Pollak, Yongqing Zhang, Y. Yu, K. Becker, V. Bohr, D. Ingram, D. Sinclair, N. Wolf, S. Spindler, M. Bernier, R. Cabo (2013)
Metformin improves healthspan and lifespan in miceNature communications, 4
-
Soléne Fastenackels, D. Sauce, C. Vigouroux, V. Avettand-Fenoël, J. Bastard, S. Fellahi, Laura Nailler, Elisa Arezes, C. Rouzioux, J. Warszawski, J. Viard, V. Appay (2019)
HIV mediated immune aging in young adults infected perinatally or during childhood.AIDS
-
H. Valdez, E. Connick, Kimberly Smith, M. Lederman, R. Bosch, Ryung Kim, M. Clair, D. Kuritzkes, H. Kessler, L. Fox, Michelle Blanchard-Vargas, A. Landay (2002)
Limited immune restoration after 3 years’ suppression of HIV-1 replication in patients with moderately advanced diseaseAIDS, 16
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Abstract
Downloaded from http://journals.lww.com/co-hivandaids by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/03/2020 REVIEW URRENT PINION Matthew A. Szaniawski and Adam M. Spivak Purpose of review To summarize the state of chronic, treated HIV infection and its contribution to accelerated aging, and to evaluate recent research relevant to the study and treatment of aging and senescence. Recent findings Chronic treated HIV-1 infection is associated with significant risk of end-organ impairment, non-AIDS- associated malignancies, and accelerated physiologic aging. Coupled with the chronologic aging of the HIV- 1-positive population, the development of therapies that target these processes is of great clinical importance. Age-related diseases are partly the result of cellular senescence. Both immune and nonimmune cell subsets are thought to mediate this senescent phenotype, a state of stable cell cycle arrest characterized by sustained release of pro-inflammatory mediators. Recent research in the field of aging has identified a number of ‘senotherapeutics’ to combat aging-related diseases, pharmacologic agents that act either by selectively promoting the death of senescent cells (‘senolytics’) or modifying senescent phenotype (‘senomorphics’). Summary Senescence is a hallmark of aging-related diseases that is characterized by stable cell cycle arrest and chronic inflammation. Chronic HIV-1 infection predisposes patients to aging-related illnesses and is similarly marked by a
Journal
Current Opinion in HIV & AIDS – Wolters Kluwer Health
Published: Mar 1, 2020