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L. Macconaill, C. Campbell, Sarah Kehoe, A. Bass, C. Hatton, Lili Niu, Matt Davis, Keluo Yao, M. Hanna, Chandrani Mondal, Lauren Luongo, Caroline Emery, Alissa Baker, Juliet Philips, Deborah Goff, M. Fiorentino, M. Rubin, K. Polyak, J. Chan, Yuexiang Wang, J. Fletcher, S. Santagata, G. Corso, F. Roviello, R. Shivdasani, M. Kieran, K. Ligon, C. Stiles, W. Hahn, M. Meyerson, L. Garraway (2009)
Profiling Critical Cancer Gene Mutations in Clinical Tumor SamplesPLoS ONE, 4
Randall Burt, James Barthel, Kelli Dunn, Donald David, Ernesto Drelichman, James Ford, F. Giardiello, Stephen Gruber, Amy Halverson, Stanley Hamilton, M. Ismail, K. Jasperson, Audrey Lazenby, Patrick Lynch, Edward Martin, Robert Mayer, Reid Ness, Dawn Provenzale, M. Rao, Moshe Shike, Gideon Steinbach, J. Terdiman, David Weinberg (2010)
NCCN clinical practice guidelines in oncology. Colorectal cancer screening.Journal of the National Comprehensive Cancer Network : JNCCN, 8 1
G. Oxnard, M. Arcila, J. Chmielecki, M. Ladanyi, V. Miller, W. Pao (2011)
New Strategies in Overcoming Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung CancerClinical Cancer Research, 17
P. Fong, D. Boss, T. Yap, A. Tutt, P. Wu, M. Mergui-Roelvink, Peter Mortimer, H. Swaisland, A. Lau, M. O’Connor, A. Ashworth, J. Carmichael, S. Kaye, J. Schellens, J. Bono (2009)
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.The New England journal of medicine, 361 2
D. Bell, A. Berchuck, M. Birrer, J. Chien, D. Cramer, F. Dao, R. Dhir, P. Disaia, H. Gabra, Pat Glenn, A. Godwin, J. Gross, L. Hartmann, M. Huang, D. Huntsman, M. Iacocca, M. Imieliński, S. Kalloger, B. Karlan, D. Levine, G. Mills, C. Morrison, D. Mutch, Narciso Olvera, S. Orsulic, K. Park, N. Petrelli, B. Rabeno, J. Rader, B. Sikic, K. Smith-McCune, A. Sood, D. Bowtell, R. Penny, J. Testa, K. Chang, H. Dinh, J. Drummond, G. Fowler, P. Gunaratne, A. Hawes, C. Kovar, L. Lewis, M. Morgan, I. Newsham, J. Santibanez, J. Reid, L. Treviño, Y. Wu, M. Wang, D. Muzny, D. Wheeler, R. Gibbs, G. Getz, M. Lawrence, K. Cibulskis, A. Sivachenko, C. Sougnez, Douglas Voet, Jane Wilkinson, Toby Bloom, K. Ardlie, T. Fennell, J. Baldwin, S. Gabriel, E. Lander, L. Ding, R. Fulton, D. Koboldt, M. McLellan, T. Wylie, Jason Walker, M. O'Laughlin, D. Dooling, L. Fulton, R. Abbott, N. Dees, Q. Zhang, C. Kandoth, M. Wendl, W. Schierding, D. Shen, C. Harris, H. Schmidt, Joelle Kalicki, K. Delehaunty, C. Fronick, Ryan Demeter, L. Cook, J. Wallis, L. Lin, V. Magrini, J. Hodges, James Eldred, S. Smith, C. Pohl, Fabio Vandin, Benjamin Raphael, G. Weinstock, E. Mardis, R. Wilson, M. Meyerson, W. Winckler, R. Verhaak, Suzie Carter, C. Mermel, G. Saksena, H. Nguyen, R. Onofrio, D. Hubbard, S. Gupta, A. Crenshaw, A. Ramos, L. Chin, A. Protopopov, Juinhua Zhang, T. Kim, I. Perna, Y. Xiao, Hailei Zhang, G. Ren, N. Sathiamoorthy, R. Park, E. Lee, P. Park, R. Kucherlapati, D. Absher, L. Waite, G. Sherlock, J. Brooks, Jun Li, Jin Xu, R. Myers, P. Laird, L. Cope, J. Herman, Hui Shen, D. Weisenberger, H. Noushmehr, F. Pan, T. Triche, B. Berman, D. Berg, J. Buckley, S. Baylin, P. Spellman, E. Purdom, P. Neuvial, H. Bengtsson, L. Jakkula, S. Durinck, J. Han, S. Dorton, H. Marr, Y. Choi, V. Wang, Ninghai Wang, J. Ngai, J. Conboy, B. Parvin, H. Feiler, T. Speed, J. Gray, N. Socci, Yanke Liang, B. Taylor, N. Schultz, L. Borsu, A. Lash, C. Brennan, A. Viale, C. Sander, M. Ladanyi, K. Hoadley, S. Meng, Y. Du, Yufeng Shi, Lulin Li, Y. Turman, D. Zang, E. Helms, S. Balu, X. Zhou, Jinhua Wu, M. Topal, D. Hayes, C. Perou, Jun Zhang, Chaowei Wu, S. Shukla, A. Sivachenko, R. Jing, Yueh-Feng Liu, M. Noble, H. Carter, D. Kim, R. Karchin, J. Korkola, Laura Heiser, R. Cho, Zhihao Hu, E. Cerami, A. Olshen, B. Reva, Yevgeniy Antipin, R. Shen, P. Mankoo, R. Sheridan, G. Ciriello, William Chang, J. Bernanke, D. Haussler, C. Benz, Joshua Stuart, S. Benz, J. Sanborn, Charles Vaske, Jiangyu Zhu, C. Szeto, G. Scott, C. Yau, M. Wilkerson, N. Zhang, R. Akbani, K. Baggerly, W. Yung, J. Weinstein, T. Shelton, D. Grimm, M. Hatfield, S. Morris, P. Yena, P. Rhodes, M. Sherman, J. Paulauskis, S. Millis, A. Kahn, J. Greene, R. Sfeir, M. Jensen, James Chen, J. Whitmore, S. Alonso, J. Jordan, A. Chu, Jinghui Zhang, A. Barker, C. Compton, G. Eley, M. Ferguson, P. Fielding, D. Gerhard, R. Myles, C. Schaefer, K. Shaw, J. Vaught, J. Vockley, P. Good, M. Guyer, B. Ozenberger, James Peterson, E. Thomson (2011)
Integrated Genomic Analyses of Ovarian CarcinomaNature, 474
S. D’Angelo, M. Pietanza, M. Johnson, Gregory Riely, V. Miller, C. Sima, M. Zakowski, V. Rusch, M. Ladanyi, M. Kris (2011)
Incidence of EGFR exon 19 deletions and L858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29 15
R. Rosell, M. Molina, C. Costa, S. Simonetti, A. Giménez-Capitán, J. Bertran-Alamillo, C. Mayo, T. Morán, P. Méndez, F. Cardenal, D. Isla, M. Provencio, M. Cobo, A. Insa, R. García-Campelo, N. Reguart, M. Majem, S. Viteri, E. Carcereny, R. Porta, B. Massutí, C. Queralt, I. Aguirre, J. Sánchez, M. Sánchez-Ronco, J. Mate, A. Ariza, S. Benlloch, J. Sánchez, T. Bivona, C. Sawyers, M. Taron (2011)
Pretreatment EGFR T790M Mutation and BRCA1 mRNA Expression in Erlotinib-Treated Advanced Non–Small-Cell Lung Cancer Patients with EGFR MutationsClinical Cancer Research, 17
K. Su, Hsuan-Yu Chen, Ker-Chau Li, M. Kuo, J. Yang, Wing-Kai Chan, Bing-Ching Ho, G. Chang, J. Shih, Sung-Liang Yu, Pan‐Chyr Yang (2012)
Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30 4
H. Vikis, Mitsuo Sato, Michael James, Daolong Wang, Yian Wang, Min Wang, D. Jia, Yan Liu, J. Bailey-Wilson, C. Amos, S. Pinney, G. Petersen, M. Andrade, Ping Yang, J. Wiest, P. Fain, A. Schwartz, A. Gazdar, C. Gaba, H. Rothschild, D. Mandal, E. Kupert, D. Seminara, A. Viswanathan, R. Govindan, J. Minna, Marshall Anderson, M. You (2007)
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity.Cancer research, 67 10
D. Bell, I. Gore, R. Okimoto, N. Godin-Heymann, Raffaella Sordella, Roseann Mulloy, Sreenath Sharma, Brian Brannigan, G. Mohapatra, J. Settleman, D. Haber (2005)
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFRNature Genetics, 37
R. Bejar, K. Stevenson, O. Abdel-Wahab, N. Galili, B. Nilsson, G. Garcia-Manero, H. Kantarjian, A. Raza, R. Levine, D. Neuberg, B. Ebert (2011)
Clinical effect of point mutations in myelodysplastic syndromes.The New England journal of medicine, 364 26
J. Chmielecki, J. Foo, G. Oxnard, K. Hutchinson, K. Ohashi, R. Somwar, Lu Wang, K. Amato, M. Arcila, M. Sos, N. Socci, A. Viale, E. Stanchina, M. Ginsberg, Roman Thomas, M. Kris, A. Inoue, M. Ladanyi, Vincent Miller, F. Michor, W. Pao (2011)
Optimization of Dosing for EGFR-Mutant Non–Small Cell Lung Cancer with Evolutionary Cancer ModelingScience Translational Medicine, 3
Jenn-Yu Wu, Chong-Jen Yu, Yeun-Chung Chang, Chih‐Hsin Yang, J. Shih, Pan‐Chyr Yang (2011)
Effectiveness of Tyrosine Kinase Inhibitors on “Uncommon” Epidermal Growth Factor Receptor Mutations of Unknown Clinical Significance in Non–Small Cell Lung CancerClinical Cancer Research, 17
C. Amos, S. Pinney, Yafang Li, E. Kupert, Juwon Lee, M. Andrade, Ping Yang, A. Schwartz, P. Fain, A. Gazdar, J. Minna, J. Wiest, D. Zeng, H. Rothschild, D. Mandal, M. You, T. Coons, C. Gaba, J. Bailey-Wilson, Marshall Anderson (2010)
A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers.Cancer research, 70 6
Al Benson, Thomas Abrams, E. Ben-Josef, P. Bloomston, Jean Botha, Bryan Clary, A. Covey, S. Curley, Michael D'Angelica, Rene Davila, William Ensminger, John Gibbs, D. Laheru, M. Malafa, J. Marrero, Steven Meranze, Sean Mulvihill, James Park, James Posey, J. Sachdev, R. Salem, Elin Sigurdson, C. Sofocleous, J. Vauthey, A. Venook, Laura Goff, Y. Yen, Andrew Zhu (2009)
NCCN clinical practice guidelines in oncology: hepatobiliary cancers.Journal of the National Comprehensive Cancer Network : JNCCN, 7 4
Koei Ikeda, H. Nomori, Takeshi Mori, J. Sasaki, Toshiaki Kobayashi (2008)
Novel germline mutation: EGFR V843I in patient with multiple lung adenocarcinomas and family members with lung cancer.The Annals of thoracic surgery, 85 4
M. Arcila, G. Oxnard, K. Nafa, Gregory Riely, S. Solomon, M. Zakowski, M. Kris, W. Pao, V. Miller, M. Ladanyi (2011)
Rebiopsy of Lung Cancer Patients with Acquired Resistance to EGFR Inhibitors and Enhanced Detection of the T790M Mutation Using a Locked Nucleic Acid-Based AssayClinical Cancer Research, 17
C. Amos, Xifeng Wu, P. Broderick, I. Gorlov, J. Gu, T. Eisen, Q. Dong, Qing Zhang, X. Gu, J. Vijayakrishnan, K. Sullivan, A. Matakidou, Yufei Wang, G. Mills, K. Doheny, Ya‐Yu Tsai, W. Chen, S. Shete, M. Spitz, R. Houlston (2008)
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1Nature Genetics, 40
N. Girard, E. Lou, C. Azzoli, R. Reddy, M. Robson, M. Harlan, I. Orlow, Y. Yatabe, K. Nafa, M. Ladanyi, A. Viale, M. Kris, Gregory Riely, V. Miller, R. Klein, K. Matsuo, W. Pao (2010)
Analysis of Genetic Variants in Never-Smokers with Lung Cancer Facilitated by an Internet-Based Blood Collection Protocol: A Preliminary ReportClinical Cancer Research, 16
BRIEF REPoRT Screening for Germline EGFR T790M Mutations Through Lung Cancer Genotyping Geoffrey R. Oxnard, MD,* Vincent A. Miller, MD,* Mark E. Robson, MD,† Christopher G. Azzoli, MD,* William Pao, MD, PhD,‡ Marc Ladanyi, MD,§ and Maria E. Arcila, MD§ Conclusions: Genotyping of lung cancers, now commonly per- Introduction: The study of patients carrying germline endothelial formed to predict benefit from treatment with EGFR tyrosine kinase growth factor receptor (EGFR) mutations, which have been found in inhibitors, can also be used as a screening tool to identify patients cases of familial lung adenocarcinoma, could provide unique insight into at risk of carrying germline EGFR mutations. o nce identified, these lung cancer risk and carcinogenesis in never-smokers. However, inves- patients and their families can be studied prospectively to explore tigations into the biology of germline EGFR mutations have been ham- appropriate lung cancer screening strategies. Further studies using pered by the lack of an effective strategy for screening for carriers. We existing oncogenomic data to provide insight into underlying ger- hypothesized that patients with lung cancers found to harbor the EGFR mline genetics are warranted. T790M resistance mutation before treatment, an uncommon occurrence, would be likely to carry underlying germline
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jun 1, 2012
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