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Safety of Contrast Agent Use During Stress Echocardiography in Patients With Elevated Right Ventricular Systolic Pressure A Cohort Study Sahar S. Abdelmoneim, MD; Mathieu Bernier, MD; Christopher G. Scott, MS; Abhijeet Dhoble, MD; Sue Ann C. Ness, RN; Mary E. Hagen, RDCS; Stuart Moir, MD; Robert B. McCully, MD; Patricia A. Pellikka, MD; Sharon L. Mulvagh, MD Background—Microbubble safety concerns led to changes in product recommendations for patients with pulmonary hypertension. Noninvasive estimation of right ventricular systolic pressure (RVSP) is equivalent to pulmonary artery systolic pressure in the absence of pulmonary outflow obstruction. We analyzed the short- and long-term outcomes of patients who received microbubble contrast and those who did not during stress echocardiography (SE) according to resting RVSP. Methods and Results—From November 2003 to December 2007, 26 774 patients underwent SE. RVSP (mean, 32.69.6 mm Hg) was measured in 16 434 patients. Of these, 6164 (37.5%) received contrast for left ventricular opacification and 10 270 (62.5%) did not. Short-term (72 hours and 30 days) and long-term (4.3 years) end points were death and myocardial infarction. Analysis was done for rest RVSP cut-points 35, 50, and 60 mm Hg and 1 1 tricuspid regurgitant velocities 2.7 ms and 3.5
Circulation: Cardiovascular Imaging – Wolters Kluwer Health
Published: May 1, 2010
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