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ORIGINAL ARTICLE Safety and Efficacy of Stereotactic Body Radiotherapy for Stage I Non–Small-Cell Lung Cancer in Routine Clinical Practice A Patterns-of-Care and Outcome Analysis Matthias Guckenberger, MD,* Michael Allgäuer, MD,† Steffen Appold, MD,‡ Karin Dieckmann, MD,§ Iris Ernst, MD,║ Ute Ganswindt, MD,¶ Richard Holy, MD,# Ursula Nestle, MD,** Meinhard Nevinny-Stickel, MD,†† Sabine Semrau, MD,‡‡ Florian Sterzing, MD,§§ Andrea Wittig, MD,║║ and Nicolaus Andratschke, MD¶¶ average follow-up of 21 months, 3-year freedom from local progres- Introduction: To evaluate safety and efficacy of stereotactic body sion (FFLP) and overall survival (OS) were 79.6% and 47.1%, respec- radiotherapy (SBRT) for stage I non–small-cell lung cancer (NSCLC) tively. The biological effective dose was the most significant factor in a patterns-of-care and patterns-of-outcome analysis. influencing FFLP and OS: after more than 106 Gy biological effective Methods: The working group “Extracranial Stereotactic dose as planning target volume encompassing dose (N = 164), 3-year Radiotherapy” of the German Society for Radiation Oncology per- FFLP and OS were 92.5% and 62.2%, respectively. No evidence of a formed a retrospective multicenter analysis of practice and outcome learning curve or improvement of results with larger SBRT experience after SBRT for stage I NSCLC. Sixteen German and Austrian centers and implementation of new radiotherapy technologies was observed. with experience in pulmonary SBRT were
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Aug 1, 2013
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