Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Role of YAP-1 in Thyroid Tumor Progression and Outcome

Role of YAP-1 in Thyroid Tumor Progression and Outcome Context:Yes-associated protein-1 (YAP-1) is a player of the Hippo pathway and is involved in regulating cell proliferation. YAP-1 is overexpressed in papillary and anaplastic thyroid cancers. However, a correlation between YAP-1 expression and outcome in thyroid carcinoma has not been conclusively demonstrated.Objective:This study was designed to clarify whether YAP-1 may be considered a marker of worse prognosis and outcome in thyroid cancer.Design:A large series of cases of thyroid cancer with a long follow-up were investigated for YAP-1 expression.Setting:The study was carried out in the Pathology section of a referral Italian center for Endocrine Surgery and Endocrinology.Patients or Other Participants:The study included a consecutive series of 105 patients who underwent thyroidectomy from 1985 to 1992. The mean follow-up was 15 years. For all patients, clinicopathologic features were considered. All patients completed the study.The study also included a consecutive series of 52 patients who underwent thyroidectomy from 2012 to 2013 in order to analyze more deeply the correlation of YAP-1expression with BRAF mutation.Intervention:The 105 thyroid tumors were immunohistochemically investigated for YAP-1 expression.Outcome Measures:We expected a correlation between YAP-1 expression and worse prognosis.Results:Among 105 tumors, 77 scored positive for YAP-1 expression, of which 68 papillary thyroid carcinomas and 9 anaplastic thyroid carcinomas were YAP-1 positive. The correlation of YAP-1 expression with clinicopathologic characteristics was significant for the absence of a tumoral capsule, gender, and extrathyroid invasion.Interestingly, significant correlations were found between YAP-1 and both persistence of disease and death from carcinoma.Conclusions:The data show an association of YAP-1 expression with worse clinicopathologic features of thyroid tumors that seem to have a specific impact on outcome. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Role of YAP-1 in Thyroid Tumor Progression and Outcome

Download PDF
5 pages

Loading next page...
 
/lp/wolters-kluwer-health/role-of-yap-1-in-thyroid-tumor-progression-and-outcome-afsv0t6hUf

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Wolters Kluwer Health
Copyright
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1062-3345
eISSN
1533-4058
DOI
10.1097/PAI.0000000000000344
pmid
27753655
Publisher site
See Article on Publisher Site

Abstract

Context:Yes-associated protein-1 (YAP-1) is a player of the Hippo pathway and is involved in regulating cell proliferation. YAP-1 is overexpressed in papillary and anaplastic thyroid cancers. However, a correlation between YAP-1 expression and outcome in thyroid carcinoma has not been conclusively demonstrated.Objective:This study was designed to clarify whether YAP-1 may be considered a marker of worse prognosis and outcome in thyroid cancer.Design:A large series of cases of thyroid cancer with a long follow-up were investigated for YAP-1 expression.Setting:The study was carried out in the Pathology section of a referral Italian center for Endocrine Surgery and Endocrinology.Patients or Other Participants:The study included a consecutive series of 105 patients who underwent thyroidectomy from 1985 to 1992. The mean follow-up was 15 years. For all patients, clinicopathologic features were considered. All patients completed the study.The study also included a consecutive series of 52 patients who underwent thyroidectomy from 2012 to 2013 in order to analyze more deeply the correlation of YAP-1expression with BRAF mutation.Intervention:The 105 thyroid tumors were immunohistochemically investigated for YAP-1 expression.Outcome Measures:We expected a correlation between YAP-1 expression and worse prognosis.Results:Among 105 tumors, 77 scored positive for YAP-1 expression, of which 68 papillary thyroid carcinomas and 9 anaplastic thyroid carcinomas were YAP-1 positive. The correlation of YAP-1 expression with clinicopathologic characteristics was significant for the absence of a tumoral capsule, gender, and extrathyroid invasion.Interestingly, significant correlations were found between YAP-1 and both persistence of disease and death from carcinoma.Conclusions:The data show an association of YAP-1 expression with worse clinicopathologic features of thyroid tumors that seem to have a specific impact on outcome.

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Sep 1, 2017

References

  • The dual functions of YAP-1 to promote and inhibit cell growth in human malignancy
  • YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes
  • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
  • Yes-associated protein (YAP) functions as a tumor suppressor in breast
  • High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
  • RAF kinase inhibitor-independent constitutive activation of Yes-associated protein 1 promotes tumor progression in thyroid cancer
  • Tumors of thyroid and parathyroid
  • European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium
  • Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer
  • Defects in iodide metabolism in thyroid cancer and implications for the follow-up and treatment of patients
  • Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder
  • Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
  • Filling out the Hippo pathway
  • From cell structure to transcription: Hippo forges a new path
  • The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version
  • Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
  • Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo
  • Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt
  • A conserved family of signal-responsive transcriptional coregulators in animal development and human disease