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Role of Recombinant Human Activated Protein C (Drotrecogin Alfa, Activated, Xigris®) for Severe Sepsis

Role of Recombinant Human Activated Protein C (Drotrecogin Alfa, Activated,... Severe sepsis is a common life-threatening disease commonly associated with systemic inflamma- tion and altered coagulation processes. Drotrecogin alfa (activated), (Xigris ) is a novel drug which has both anti-inflammatory and anticoagulant properties and was approved in 2001 for the reduction in mortality in patients with severe sepsis at a high risk of death. It is currently unclear which subset of patients with severe sepsis is most likely to benefit from this therapy; however, the most severely ill patient with multiple organ dysfunction appear to gain the most benefit. Key words: drotrecogin alfa activated, protein C, sepsis cians; however, a better understanding of the ESPITE advances in technology re- pathophysiology has allowed more rational, lated to critical care, sepsis contin- Dues to cause significant morbidity and evidenced-based algorithms to be developed. mortality. Approximately 750,000 cases of Specifically, an understanding of the contribu- sepsis occur each year in the United States tions of inflammatory mediators and proco- with an associated mortality of 25% to 70% agulant factors on the sepsis process has al- (25%–30% for severe sepsis and 40%–70% lowed for the research and development of for septic shock) and this number is only more targeted therapeutic agents. Drotreco- expected http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Emergency Nursing Journal Wolters Kluwer Health

Role of Recombinant Human Activated Protein C (Drotrecogin Alfa, Activated, Xigris®) for Severe Sepsis

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Copyright
© 2007 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1931-4485
eISSN
1931-4493
DOI
10.1097/01.TME.0000286963.71416.73

Abstract

Severe sepsis is a common life-threatening disease commonly associated with systemic inflamma- tion and altered coagulation processes. Drotrecogin alfa (activated), (Xigris ) is a novel drug which has both anti-inflammatory and anticoagulant properties and was approved in 2001 for the reduction in mortality in patients with severe sepsis at a high risk of death. It is currently unclear which subset of patients with severe sepsis is most likely to benefit from this therapy; however, the most severely ill patient with multiple organ dysfunction appear to gain the most benefit. Key words: drotrecogin alfa activated, protein C, sepsis cians; however, a better understanding of the ESPITE advances in technology re- pathophysiology has allowed more rational, lated to critical care, sepsis contin- Dues to cause significant morbidity and evidenced-based algorithms to be developed. mortality. Approximately 750,000 cases of Specifically, an understanding of the contribu- sepsis occur each year in the United States tions of inflammatory mediators and proco- with an associated mortality of 25% to 70% agulant factors on the sepsis process has al- (25%–30% for severe sepsis and 40%–70% lowed for the research and development of for septic shock) and this number is only more targeted therapeutic agents. Drotreco- expected

Journal

Advanced Emergency Nursing Journal – Wolters Kluwer Health

Published: Jul 1, 2007

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