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Role of PAX-8, CD5, and CD117 in Distinguishing Thymic Carcinoma From Poorly Differentiated Lung Carcinoma

Role of PAX-8, CD5, and CD117 in Distinguishing Thymic Carcinoma From Poorly Differentiated Lung... RESEARCH ARTICLE Role of PAX-8, CD5, and CD117 in Distinguishing Thymic Carcinoma From Poorly Differentiated Lung Carcinoma Jaya R. Asirvatham, MBBS, MD, Michael J. Esposito, MD, and Tawfiqul A. Bhuiya, MD of genes (PAX-1 to 9) are nuclear transcription factors Aim: To determine if PAX-8, CD5, and CD117 can differentiate expressed only during organogenesis, in the epithelium of thymic carcinoma from poorly differentiated lung carcinoma. specific organs. PAX-8 is expressed in the thyroid, kidney, ureter, ovary, uterus, and cervix. During neoplastic Design: Archived cases of thymic (n = 13) and poorly differ- transformation of the epithelium of these organs, the entiated lung (n = 15) carcinoma were analyzed for intensity PAX genes are reexpressed. Metastatic carcinomas orig- and proportion of expression of PAX-8, CD117, and CD5. inating from these organs can also express PAX-8. Results: PAX-8 was positive in 69.2% of thymic and 5.8% of Tumors originating from mesenchymal components are lung carcinomas. CD117 was positive in 84% of thymic and PAX negative. 26.6% of lung carcinomas. A total of 53% of thymic and none of the lung carcinomas were positive for CD5. Forty-six percent, AIM 53%, and 69% of thymic carcinomas were dual positive for The aim of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Role of PAX-8, CD5, and CD117 in Distinguishing Thymic Carcinoma From Poorly Differentiated Lung Carcinoma

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e318297cdb5
pmid
23958552
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Role of PAX-8, CD5, and CD117 in Distinguishing Thymic Carcinoma From Poorly Differentiated Lung Carcinoma Jaya R. Asirvatham, MBBS, MD, Michael J. Esposito, MD, and Tawfiqul A. Bhuiya, MD of genes (PAX-1 to 9) are nuclear transcription factors Aim: To determine if PAX-8, CD5, and CD117 can differentiate expressed only during organogenesis, in the epithelium of thymic carcinoma from poorly differentiated lung carcinoma. specific organs. PAX-8 is expressed in the thyroid, kidney, ureter, ovary, uterus, and cervix. During neoplastic Design: Archived cases of thymic (n = 13) and poorly differ- transformation of the epithelium of these organs, the entiated lung (n = 15) carcinoma were analyzed for intensity PAX genes are reexpressed. Metastatic carcinomas orig- and proportion of expression of PAX-8, CD117, and CD5. inating from these organs can also express PAX-8. Results: PAX-8 was positive in 69.2% of thymic and 5.8% of Tumors originating from mesenchymal components are lung carcinomas. CD117 was positive in 84% of thymic and PAX negative. 26.6% of lung carcinomas. A total of 53% of thymic and none of the lung carcinomas were positive for CD5. Forty-six percent, AIM 53%, and 69% of thymic carcinomas were dual positive for The aim of

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: May 1, 2014

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