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Role of HERV-W Syncytin-1

Role of HERV-W Syncytin-1 RESEARCH ARTICLE Role of HERV-W Syncytin-1 in Placentation and Maintenance of Human Pregnancy Samina Noorali, PhD,* Ioana C. Rotar, MD,* Cindi Lewis, BSc,w Joseph P. Pestaner, MD,z Donald Gene Pace, PhD,w Antonio Sison, MD,y and Omar Bagasra, MD, PhD* ne of the most remarkable outcomes from the Abstract: Over half of human genome contains retroelements, Ohuman genome project is the revelation that more including retrotransposons, retroviruses, and other elements. genetic material has been incorporated into our genome Human endogenous retroviruses (HERVs) comprise about by laterally transmitted agents than by natural selection. 8% of human genome. The products of 2 of 16 identified genes The human genome has a larger repertoire of the of HERV-W seem to play a pivotal role in the placentation. remnants of once defective infectious retroviruses than These 2 genes are HERV-W env glycoprotein (syncytin-1) and does protein-coding genetic material, which only accounts 1–3 HERV-FRD env glycoprotein (syncytin-2). It has been shown for a very small chunk of our DNA. Human previously that syncytin-1 mediates cell-cell fusions of cyto- endogenous retroviruses (HERVs) occupy about 8% of trophoblasts into syncytiotrophoblasts. In addition, HERV-W our DNA, and comprise at least 31 distinct families, the env contains an immunosuppressive http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Role of HERV-W Syncytin-1

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References (54)

ISSN
1541-2016
DOI
10.1097/PAI.0b013e31819640f9
pmid
19407656
Publisher site
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Abstract

RESEARCH ARTICLE Role of HERV-W Syncytin-1 in Placentation and Maintenance of Human Pregnancy Samina Noorali, PhD,* Ioana C. Rotar, MD,* Cindi Lewis, BSc,w Joseph P. Pestaner, MD,z Donald Gene Pace, PhD,w Antonio Sison, MD,y and Omar Bagasra, MD, PhD* ne of the most remarkable outcomes from the Abstract: Over half of human genome contains retroelements, Ohuman genome project is the revelation that more including retrotransposons, retroviruses, and other elements. genetic material has been incorporated into our genome Human endogenous retroviruses (HERVs) comprise about by laterally transmitted agents than by natural selection. 8% of human genome. The products of 2 of 16 identified genes The human genome has a larger repertoire of the of HERV-W seem to play a pivotal role in the placentation. remnants of once defective infectious retroviruses than These 2 genes are HERV-W env glycoprotein (syncytin-1) and does protein-coding genetic material, which only accounts 1–3 HERV-FRD env glycoprotein (syncytin-2). It has been shown for a very small chunk of our DNA. Human previously that syncytin-1 mediates cell-cell fusions of cyto- endogenous retroviruses (HERVs) occupy about 8% of trophoblasts into syncytiotrophoblasts. In addition, HERV-W our DNA, and comprise at least 31 distinct families, the env contains an immunosuppressive

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Jul 1, 2009

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