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ORIGINAL ARTICLE Role of Computed Tomography Voxel Size in Detection and Discrimination of Calcium and Iron Deposits in Atherosclerotic Human Coronary Artery Specimens Alexander C. Langheinrich, MD,*Þ Marian Kampschulte, MD,*Þ Christine Cro¨Amann, MD,*Þ Regina Moritz, MD,þ Wigbert S. Rau, MD,*Þ Rainer M. Bohle, MD,þ and Erik L. Ritman, MD, PhD§ decade, several clinical imaging techniques, especially magnetic Objective: This study evaluated the influence of voxel size on its 2Y4 resonance imaging and multislice computed tomography or ability to discriminate calcium from iron deposits in ex vivo coronary 5Y7 microYcomputed tomography (CT), have been developed and arteries. used to explore how well atherosclerotic lesions can be detected Methods: Postmortem human coronary arteries underwent multislice and classified in vivo or experimentally. The relation of fibro- computed tomographic scan at (600-Km) voxel size to provide an index calcified lesions, as determined by CT using the Agatston score, of computed tomography (CT) image noise and synchrotron-based 8Y10 and cardiovascular events has been demonstrated. However, micro-CT at (4<Km) voxel size to provide data for generating a range of the validity of the CT grayscale values of small opacities in the voxel sizes 4 to (600<Km) after grayscale noise was added to the pro- arterial
Journal of Computer Assisted Tomography – Wolters Kluwer Health
Published: Jul 1, 2009
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