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Role of Carbon Ion Therapy for Stage I NSCLC Using a Regimen of Four Fractions over Week

Role of Carbon Ion Therapy for Stage I NSCLC Using a Regimen of Four Fractions over Week EDITORIAL Role of Carbon Ion Therapy for Stage I NSCLC Using a Regimen of Four Fractions over Week Robert Orecchia, MD, and Piero Fossati, MS, MD tage I NSCLC can be cured with radical surgery; the reported 5-years overall survival Srate ranged from 55% up more than 70%. Even with modern techniques there is a low, but nonzero, in-hospital death rate of 0.8%. Lobectomy, performed by thoracothomy or video-assisted thoracoscopic approach is the surgical procedure of choice, being more limited resection less effective in local control rates. Loss of pulmonary parenchyma has a negative impact on respiratory function and can reflect in a decreased quality of life. In the past, patients unable to withstand lobectomy and/or the related surgical stress have been traditionally treated with standard radiotherapy (RT) at doses of about 60 Gray. The outcomes were clearly inferior to those of surgery with reported 5-years overall survival of 23%. Modern high precision photons radiotherapy (Image-Guided RT and others) can be substantially more effective. For example, stereotactic technique (SRT) allow to selectively deliver higher doses to the detectable tumor (plus a margin). Hypofractionated schedules with only few (typically less than 5) treatment sessions are given. A large retrospective analysis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Role of Carbon Ion Therapy for Stage I NSCLC Using a Regimen of Four Fractions over Week

Journal of Thoracic Oncology , Volume 2 (10) – Oct 1, 2007

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References (10)

ISSN
1556-0864
DOI
10.1097/JTO.0b013e318156af4e
pmid
17909348
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Role of Carbon Ion Therapy for Stage I NSCLC Using a Regimen of Four Fractions over Week Robert Orecchia, MD, and Piero Fossati, MS, MD tage I NSCLC can be cured with radical surgery; the reported 5-years overall survival Srate ranged from 55% up more than 70%. Even with modern techniques there is a low, but nonzero, in-hospital death rate of 0.8%. Lobectomy, performed by thoracothomy or video-assisted thoracoscopic approach is the surgical procedure of choice, being more limited resection less effective in local control rates. Loss of pulmonary parenchyma has a negative impact on respiratory function and can reflect in a decreased quality of life. In the past, patients unable to withstand lobectomy and/or the related surgical stress have been traditionally treated with standard radiotherapy (RT) at doses of about 60 Gray. The outcomes were clearly inferior to those of surgery with reported 5-years overall survival of 23%. Modern high precision photons radiotherapy (Image-Guided RT and others) can be substantially more effective. For example, stereotactic technique (SRT) allow to selectively deliver higher doses to the detectable tumor (plus a margin). Hypofractionated schedules with only few (typically less than 5) treatment sessions are given. A large retrospective analysis

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Oct 1, 2007

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