Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Rheb/mTOR/p70s6k Cascade and TFE3 Expression in Conventional and Sclerosing PEComas of the Urinary Tract

Rheb/mTOR/p70s6k Cascade and TFE3 Expression in Conventional and Sclerosing PEComas of... RESEARCH ARTICLE Rheb/mTOR/p70s6k Cascade and TFE3 Expression in Conventional and Sclerosing PEComas of the Urinary Tract Marı´a Planelles, MD,* Laura Macı´as, MD,w Gloria Peiro´,MD,* Stela Bulimbasicˇ,MD,z Ondrej Hes, MD,y Antonio Robles, MD,w Michal Michal, MD,y Whitney Davidson, BS, PSF,8 and Jose´ I. Lo´pez, MDz Bonetti et al in 1992. Although these tumors show a wide Abstract: Perivascular epithelioid cell tumors (PEComas) are topographical distribution, few cases have been reported 2–5 rarely found in the urinary tract. The clinicopathologic char- within the urinary tract. The histologic features and acteristics of 10 cases, retrospectively collected from 5 medical typical immunohistochemical profile of conventional institutions in 3 different European countries, are presented in PEComas are well known. Sclerosing PEComa is a dis- this study. Male/female ratio was 3:7 and the average age at tinct variant that displays prominent stromal hyaliniza- diagnosis was 62.7 years. Nine cases were sporadic and 1 showed tion and a predisposition for the retroperitoneum. germline mutation of the TSC2 gene. Eight cases were located in Molecular genetic studies repeatedly reveal allelic the kidney, 1 in the left adrenal and 1 in the right ureter. All of loss of the TSC2 locus on 16p13 in PEComas, angio- the patients http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Rheb/mTOR/p70s6k Cascade and TFE3 Expression in Conventional and Sclerosing PEComas of the Urinary Tract

Ló pez, José I.
Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Aug 1, 2015
Download PDF
7 pages

Loading next page...
 
/lp/wolters-kluwer-health/rheb-sol-mtor-sol-p70s6k-cascade-and-tfe3-expression-in-conventional-i180Whiwr0
Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000209
pmid
26258755
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Rheb/mTOR/p70s6k Cascade and TFE3 Expression in Conventional and Sclerosing PEComas of the Urinary Tract Marı´a Planelles, MD,* Laura Macı´as, MD,w Gloria Peiro´,MD,* Stela Bulimbasicˇ,MD,z Ondrej Hes, MD,y Antonio Robles, MD,w Michal Michal, MD,y Whitney Davidson, BS, PSF,8 and Jose´ I. Lo´pez, MDz Bonetti et al in 1992. Although these tumors show a wide Abstract: Perivascular epithelioid cell tumors (PEComas) are topographical distribution, few cases have been reported 2–5 rarely found in the urinary tract. The clinicopathologic char- within the urinary tract. The histologic features and acteristics of 10 cases, retrospectively collected from 5 medical typical immunohistochemical profile of conventional institutions in 3 different European countries, are presented in PEComas are well known. Sclerosing PEComa is a dis- this study. Male/female ratio was 3:7 and the average age at tinct variant that displays prominent stromal hyaliniza- diagnosis was 62.7 years. Nine cases were sporadic and 1 showed tion and a predisposition for the retroperitoneum. germline mutation of the TSC2 gene. Eight cases were located in Molecular genetic studies repeatedly reveal allelic the kidney, 1 in the left adrenal and 1 in the right ureter. All of loss of the TSC2 locus on 16p13 in PEComas, angio- the patients

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Aug 1, 2015

There are no references for this article.