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Editorial Michael T. Lu, MD ementia, defined as a progressive cognitive decline inter - CHS (Cardiovascular Health Study-Cognition Study) of 311 Dfering with daily activities and independence, is per- of the oldest old aged ≥80 years found a significant associa- haps the most feared of the diseases we associate with aging. tion between CAC and incident dementia in white women Fifteen percent of people over age 70 years are afflicted, with only. No association was found in men or other races, pos- annual costs of ≤$215 billion in the United States. Substantial sibly because of high prevalence of CAC in men of this age resources have been martialed to understand the pathophysiol- and insufficient sample size. ogy of dementia toward prevention and a cure. It is in this context that Fujiyoshi et al provide the first large longitudinal multiethnic study supporting the associa- See Article by Fujiyoshi et al tion of baseline CAC with incident dementia in this issue of It is increasingly recognized that the 2 most common Circulation: Cardiovascular Imaging. This ancillary study subtypes of dementia, Alzheimer’s disease and vascular of MESA (Multi-Ethnic Study of Atherosclerosis) included dementia, have substantial histopathologic overlap. Several 6293 participants aged 45
Circulation: Cardiovascular Imaging – Wolters Kluwer Health
Published: May 1, 2017
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