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Cheville (1997)
The focus of “atypical glands, suspicious for malignancy” in prostatic needle biopsy specimens: incidence, histologic features, and clinical follow-up of cases diagnosed in a community practiceAm J Clin Pathol, 108
Hosler (2005)
Basal cell hyperplasia: an unusual diagnostic dilemma on prostate needle biopsiesHum Pathol, 36
Epstein (2006)
Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: implications for patient careJ Urol, 175
Gaudin (1994)
Adenosis of the prostate. Histologic features in transurethral resection specimensAm J Surg Pathol, 18
Egevad (2006)
Current practice of diagnosis and reporting of prostate cancer on needle biopsy among genitourinary pathologistsHum Pathol, 37
Al-Ahmadie (2008)
Anterior-predominant prostatic tumors: zone of origin and pathologic outcomes at radical prostatectomyAm J Surg Pathol, 32
Egevad (2006)
Current practice of diagnosis and reporting of prostatic intraepithelial neoplasia and glandular atypia among genitourinary pathologistsMod Pathol, 19
Herawi (2005)
Small glandular proliferations on needle biopsies: most common benign mimickers of prostatic adenocarcinoma sent in for expert second opinionAm J Surg Pathol, 29
Girasole (2006)
Significance of atypical and suspicious small acinar proliferations, and high grade prostatic intraepithelial neoplasia on prostate biopsy: implications for cancer detection and biopsy strategyJ Urol, 175
Mearini (2008)
Is there any clinical parameter able to predict prostate cancer after initial diagnosis of atypical small acinar proliferation?Urol Int, 81
Fadare (2004)
Practice patterns of clinicians following isolated diagnoses of atypical small acinar proliferation on prostate biopsy specimensArch Pathol Lab Med, 128
Chan (1999)
Follow-up of atypical prostate needle biopsies suspicious for cancerUrology, 53
Hameed (2010)
Pseudoneoplastic mimics of prostate and bladder carcinomasArch Pathol Lab Med, 134
Iczkowski (1997)
Atypical small acinar proliferation suspicious for malignancy in prostate needle biopsies: clinical significance in 33 casesAm J Surg Pathol, 21
Lopez (2007)
Prostate adenocarcinoma detected after high-grade prostatic intraepithelial neoplasia or atypical small acinar proliferationBJU Int, 100
Prostate biopsies with foci of atypical glands suspicious, but not diagnostic of carcinoma (ATYP) are associated with an increased risk of cancer diagnosis in subsequent biopsies. The significance of similar findings in transurethral resections of the prostate (TURP) is unknown. A total of 1338 specimens without a diagnosis of cancer were retrieved from our surgical pathology files from 1994 through 2014. Of these, 18 cases (1.3%) were identified with the diagnosis of ATYP. Immunohistochemistry (IHC) for p63, high molecular weight cytokeratin, and racemase (PIN4) was performed in all cases. The cases were grouped based on the main benign mimicker of cancer that could not be excluded from the differential diagnosis and prevented a definitive diagnosis. Adenosis accounted for 50% of the cases (9/18), 33.3% of the cases (6/18) were cautery artifact, 11% of the cases (2/18) were basal-cell hyperplasia with nucleoli and 5.6%, a single case, cribriform clear cell hyperplasia could not be excluded. Eight patients had follow-up biopsies and 2 were diagnosed with prostatic adenocarcinoma Gleason grade 3+3=6; both were alive 3 years after initial diagnosis. Although the most frequent benign mimickers that prevent a definitive diagnosis of cancer in needle biopsies are the small size of the atypical foci, PIN and partial atrophy, in TURPs, they are adenosis and cautery artifact. The rate of cancer diagnosed in follow-up is similar or lower than in patients with prior benign prostate needle biopsies and significantly lower than in patients with a prior diagnosis of ATYP in biopsies of the peripheral zone.
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Mar 1, 2018
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