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Arteriosclerosis, Thrombosis, and Vascular Biology LETTER TO THE EDITOR Response by Mackman et al to Letter Regarding Article, “Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality—Brief Report” Nigel Mackman , Yohei Hisada, Steven P. Grover , Axel Rosell , Sebastian Havervall, Fien von Meijenfeldt , Katherina Aguilera, Ton Lisman , Charlotte Thålin In Response: F. Dignat-George, personnel communication). We agree We would like to thank Brambilla et al for their inter- with Brambilla et al that there have been several sporadic est in our article showing that patients with coronavirus reports of TF protein-positive EVs in plasma samples from disease 2019 (COVID-19) have elevated levels of EVTF clinical samples by difference groups. However, none of (extracellular vesicle tissue factor) activity and that EVTF these studies present positive and negative controls, and activity is prognostic for mortality. they often use commercial anti-TF antibodies that may or 10,11 A prognostic marker is defined as a marker that is may not recognize TF. Therefore, it remains unclear associated with outcome of a disease. EVTF activity fits what is being measured in these studies. this definition without a need to define
Arteriosclerosis Thrombosis and Vascular Biology – Wolters Kluwer Health
Published: Jun 27, 2021
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