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Relevance of Immunocytochemistry on Thin-layer Cytology in Thyroid Lesions Suspicious for Medullary Carcinoma A Case-control Study

Relevance of Immunocytochemistry on Thin-layer Cytology in Thyroid Lesions Suspicious for... RESEARCH ARTICLE Relevance of Immunocytochemistry on Thin-layer Cytology in Thyroid Lesions Suspicious for Medullary Carcinoma A Case-control Study Esther Diana Rossi, MD,* Marco Raffaelli, MD,w Antonino Mule`,MD,* Gian Franco Zannoni, MD,* Alfredo Pontecorvi, MD,z Giuseppe Santeusanio, MD,y Corrado Minimo, MD,J and Guido Fadda, MD* Conclusions: ICC can be successfully applied on TLC slides. The Background: Fine needle aspiration cytology represents the most combined results of morphology and a small immunopanel important tool in the diagnosis of thyroid nodules, mostly including thyroglobulin, calcitonin, and carcinoembryonic anti- in discriminating malignant from benign lesions. The diagnosis gen yields a 100% diagnostic efficacy for MTC. of medullary thyroid carcinoma (MTC) may present some Condensed Abstract: Fine needle aspiration cytology is an problems related to its deceptive morphologic picture. This excellent technique for diagnosing malignant neoplasms of the diagnosis may be supported by immunocytochemistry (ICC), thyroid, especially those derived from the follicular cells. A which may be difficult to carry out on the conventional smears. correct preoperative diagnosis of C-cell–derived tumors (MTC), Design: The diagnostic efficacy of ICC for the diagnosis of MTC which is essential for both the surgical approach to the primary with respect to other thyroid neoplasms on slides processed by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Relevance of Immunocytochemistry on Thin-layer Cytology in Thyroid Lesions Suspicious for Medullary Carcinoma A Case-control Study

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181690ca3
pmid
18685492
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Relevance of Immunocytochemistry on Thin-layer Cytology in Thyroid Lesions Suspicious for Medullary Carcinoma A Case-control Study Esther Diana Rossi, MD,* Marco Raffaelli, MD,w Antonino Mule`,MD,* Gian Franco Zannoni, MD,* Alfredo Pontecorvi, MD,z Giuseppe Santeusanio, MD,y Corrado Minimo, MD,J and Guido Fadda, MD* Conclusions: ICC can be successfully applied on TLC slides. The Background: Fine needle aspiration cytology represents the most combined results of morphology and a small immunopanel important tool in the diagnosis of thyroid nodules, mostly including thyroglobulin, calcitonin, and carcinoembryonic anti- in discriminating malignant from benign lesions. The diagnosis gen yields a 100% diagnostic efficacy for MTC. of medullary thyroid carcinoma (MTC) may present some Condensed Abstract: Fine needle aspiration cytology is an problems related to its deceptive morphologic picture. This excellent technique for diagnosing malignant neoplasms of the diagnosis may be supported by immunocytochemistry (ICC), thyroid, especially those derived from the follicular cells. A which may be difficult to carry out on the conventional smears. correct preoperative diagnosis of C-cell–derived tumors (MTC), Design: The diagnostic efficacy of ICC for the diagnosis of MTC which is essential for both the surgical approach to the primary with respect to other thyroid neoplasms on slides processed by

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Dec 1, 2008

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