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Relationship of Lipoprotein Cholesterol Concentrations to Experimental Atherosclerosis in Baboons

Relationship of Lipoprotein Cholesterol Concentrations to Experimental Atherosclerosis in Baboons For 26 months, we fed 60 baboons a high saturated fat, high cholesterol diet that contained very low concentrations of four common pesticides (chlordane, parathlon, dlazlnon, and carbofuran). We detected no effect of pesticides on body weight, serum llpld, or Iipoprotein cholesterol concentrations, or experimental atherosclerosis. We then examined the associations of serum llpld and Iipoprotein cholesterol concentrations {predictor variables) with arterial lesions (naponto variables). Among predictor variables, very low density Iipoprotein plus low density Iipoprotein cholesterol concentration showed a positive association with fatty streaks in the aorta and its major branches, Including the coronary arteries, while high density Iipoprotein cholesterol concentration showed a consistently negative association. The very low density Iipoprotein plus low density llpoproteln/hlgh density Iipoprotein cholesterol ratio was more highly associated with lesions than was either value alone. These results are consistent with epidemlologic evidence suggesting that high density Iipoprotein cholesterol concentration Is Inversely related to probability of developing clinically manifest atherosclerotic disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Relationship of Lipoprotein Cholesterol Concentrations to Experimental Atherosclerosis in Baboons

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Copyright
© 1981 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

For 26 months, we fed 60 baboons a high saturated fat, high cholesterol diet that contained very low concentrations of four common pesticides (chlordane, parathlon, dlazlnon, and carbofuran). We detected no effect of pesticides on body weight, serum llpld, or Iipoprotein cholesterol concentrations, or experimental atherosclerosis. We then examined the associations of serum llpld and Iipoprotein cholesterol concentrations {predictor variables) with arterial lesions (naponto variables). Among predictor variables, very low density Iipoprotein plus low density Iipoprotein cholesterol concentration showed a positive association with fatty streaks in the aorta and its major branches, Including the coronary arteries, while high density Iipoprotein cholesterol concentration showed a consistently negative association. The very low density Iipoprotein plus low density llpoproteln/hlgh density Iipoprotein cholesterol ratio was more highly associated with lesions than was either value alone. These results are consistent with epidemlologic evidence suggesting that high density Iipoprotein cholesterol concentration Is Inversely related to probability of developing clinically manifest atherosclerotic disease.

Journal

ArteriosclerosisWolters Kluwer Health

Published: Jan 1, 1981

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