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Relationship between Sensitivity to Dietary Fat and Dietary Cholesterol

Relationship between Sensitivity to Dietary Fat and Dietary Cholesterol A group of 56 hypercholesterolemic and normocholesterolemic men and women were given approximately 700 mg a day of egg yolk cholesterol In a double-blind, crossover study while they were on a background diet containing approximately 30&percnt; of energy as fat. Overall there was a 0.23 mmol/l rise In plasma cholesterol (3.7&percnt;, p< 0.001) after 4 weeks, a 0.19 mmol/l rise in low density lipoprotein (LDL) cholesterol (4.9&percnt;, p= 0.002), and a 0.07 mmol/l rise In high density lipoprotein (HDL) cholesterol (5.4&percnt;, p< 0.001). Plasma trlglycerides fell by 0.07 mmol/l (5.1&percnt;). Normocholesterolemic Individuals (plasma cholesterol <5.2 mmol/l) experienced small, nonsignificant rises of 0.06, 0.02, and 0.05 mmol/l In total, LDL, and HDL cholesterol, respectively. Hypercholesterolemic sub|ects were classified on the basis of their response to a low fat diet. Diet-sensitive sub|ects were defined by a > 10&percnt; fall In plasma cholesterol on a 25&percnt; fat, low cholesterol (<200 mg/day) diet These individuals were found to be more responsive to the effect of dietary cholesterol than were dlet-insensltlve subjects; the respective changes In the two groups were rises of 0.36 mmol/l versus 0.19 mmol/l In plasma cholesterol (p= 0.06) and rises of 0.30 versus 0.15 mmol/l in LDL cholesterol (p= 0.06). In addition to elevating HDL cholesterol by 0.09 mmol/l and 0.07 mmol/l, respectively, dietary cholesterol also produced an Increase In the proportion of HDL2, from 40&percnt; to 44&percnt; of HDL protein (p< 0.001). The change in both LDL and HDL cholesterol with dietary cholesterol supplementation was related to the change with fat supplementation (r= 0.35, p< 0.05 andr=0.45, p< 0.001, respectively). However, normocholesterolemic individuals who are not particularly responsive to dietary cholesterol may, nevertheless, also need to consider such restrictions, especially if they are at risk for atherosclerosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Relationship between Sensitivity to Dietary Fat and Dietary Cholesterol

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Copyright
© 1990 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

A group of 56 hypercholesterolemic and normocholesterolemic men and women were given approximately 700 mg a day of egg yolk cholesterol In a double-blind, crossover study while they were on a background diet containing approximately 30&percnt; of energy as fat. Overall there was a 0.23 mmol/l rise In plasma cholesterol (3.7&percnt;, p< 0.001) after 4 weeks, a 0.19 mmol/l rise in low density lipoprotein (LDL) cholesterol (4.9&percnt;, p= 0.002), and a 0.07 mmol/l rise In high density lipoprotein (HDL) cholesterol (5.4&percnt;, p< 0.001). Plasma trlglycerides fell by 0.07 mmol/l (5.1&percnt;). Normocholesterolemic Individuals (plasma cholesterol <5.2 mmol/l) experienced small, nonsignificant rises of 0.06, 0.02, and 0.05 mmol/l In total, LDL, and HDL cholesterol, respectively. Hypercholesterolemic sub|ects were classified on the basis of their response to a low fat diet. Diet-sensitive sub|ects were defined by a > 10&percnt; fall In plasma cholesterol on a 25&percnt; fat, low cholesterol (<200 mg/day) diet These individuals were found to be more responsive to the effect of dietary cholesterol than were dlet-insensltlve subjects; the respective changes In the two groups were rises of 0.36 mmol/l versus 0.19 mmol/l In plasma cholesterol (p= 0.06) and rises of 0.30 versus 0.15 mmol/l in LDL cholesterol (p= 0.06). In addition to elevating HDL cholesterol by 0.09 mmol/l and 0.07 mmol/l, respectively, dietary cholesterol also produced an Increase In the proportion of HDL2, from 40&percnt; to 44&percnt; of HDL protein (p< 0.001). The change in both LDL and HDL cholesterol with dietary cholesterol supplementation was related to the change with fat supplementation (r= 0.35, p< 0.05 andr=0.45, p< 0.001, respectively). However, normocholesterolemic individuals who are not particularly responsive to dietary cholesterol may, nevertheless, also need to consider such restrictions, especially if they are at risk for atherosclerosis.

Journal

ArteriosclerosisWolters Kluwer Health

Published: May 1, 1990

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