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Regulation of Hypoxia-Inducible Genes by PGC-1&agr;

Regulation of Hypoxia-Inducible Genes by PGC-1&agr; ATVB in Focus Oxygen Sensing Series Editor: Frank Giordano Regulation of Hypoxia-Inducible Genes by PGC-1 Jonathan Shoag, Zolt Arany Abstract—Atmospheric oxygen appeared approximately 2.3 billion years ago and sustains most complex life on earth. As mitochondria evolved to harness the energy in oxygen, systems developed to sense and respond to local oxygen concentrations and metabolic conditions. For more than a decade, research has focused on hypoxia-inducible factor 1 (HIF1), a key component of the eukaryotic oxygen-response system. Recently, evidence for other systems has also surfaced. One of these systems involves the PGC-1 coactivator, a powerful transcriptional regulator of mitochondria and oxidative metabolic programs. This brief review will focus on this burgeoning role for PGC-1 and will highlight the many questions that remain unanswered. (Arterioscler Thromb Vasc Biol. 2010;30:662-666.) Key Words: angiogenesis hypoxia ischemia PGC-1 PGC-1 PGC-1 Transcriptional Coactivators brown fat, including high mitochondrial content and the Transcriptional coactivators are proteins that bind to tran- induction of the mitochondrial uncoupler uncoupling protein scription factors on chromatin and modify gene expression, (UCP)-1. In the liver, in response to fasting, PGC-1 induces 1 6,7 without themselves recognizing specific DNA sequences. It genes involved in gluconeogenesis and fatty acid oxidation. is likely that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis, Thrombosis, and Vascular Biology Wolters Kluwer Health

Regulation of Hypoxia-Inducible Genes by PGC-1&agr;

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ISSN
1079-5642
eISSN
1524-4636
DOI
10.1161/ATVBAHA.108.181636
pmid
19948845

Abstract

ATVB in Focus Oxygen Sensing Series Editor: Frank Giordano Regulation of Hypoxia-Inducible Genes by PGC-1 Jonathan Shoag, Zolt Arany Abstract—Atmospheric oxygen appeared approximately 2.3 billion years ago and sustains most complex life on earth. As mitochondria evolved to harness the energy in oxygen, systems developed to sense and respond to local oxygen concentrations and metabolic conditions. For more than a decade, research has focused on hypoxia-inducible factor 1 (HIF1), a key component of the eukaryotic oxygen-response system. Recently, evidence for other systems has also surfaced. One of these systems involves the PGC-1 coactivator, a powerful transcriptional regulator of mitochondria and oxidative metabolic programs. This brief review will focus on this burgeoning role for PGC-1 and will highlight the many questions that remain unanswered. (Arterioscler Thromb Vasc Biol. 2010;30:662-666.) Key Words: angiogenesis hypoxia ischemia PGC-1 PGC-1 PGC-1 Transcriptional Coactivators brown fat, including high mitochondrial content and the Transcriptional coactivators are proteins that bind to tran- induction of the mitochondrial uncoupler uncoupling protein scription factors on chromatin and modify gene expression, (UCP)-1. In the liver, in response to fasting, PGC-1 induces 1 6,7 without themselves recognizing specific DNA sequences. It genes involved in gluconeogenesis and fatty acid oxidation. is likely that

Journal

Arteriosclerosis, Thrombosis, and Vascular BiologyWolters Kluwer Health

Published: Apr 1, 2010

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