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To Investigate the regional variability In arterial and venous endothellal prostacyclin (PGIj) biosynthesis, we obtained 1-cm segments of carotid arteries, external jugular veins, femoral arteries and veins, lilac arteries and veins, Inferior venae cavae (IVC), and aortas from 17 dogs. Vessel lumlnal PGI2production was measured In the basal state by radlolmmunoassay of 6-keto-prostaglandln F1o(6-keto-PGF1a). A total of 90 arterial specimens (57, 19, and 14 segments, respectively, of femoral/carotid arteries, lilac arteries, and aorta) and 41 venous specimens (15,10, and 16 segments, respectively, of femoral/jugular veins, lilac veins, and IVC) were analyzed. Overall, arterial endothellal 6-keto-PGF1awas higher than venous (8.1 ±0.5 ng/ml vs. 4.9±0.7 ng/ml, p<0.0004); 6-keto-PGF1alevels were greater In the arteries than In their corresponding veins [femoral/carotid arteries (6.3±0.4 ng/ml) vs. femoral/jugular vein (2.1 ±0.4 ng/ml), /xO.0002; Iliac arteries (9.3±1.0 ng/ml) vs. iliac veins (4.8±0.9 ng/ml), /xO.005; aorta (14.0±1.6 ng/ml) vs. IVC (7.5±1.4 ng/ml), /X0.006]. Within each type and vessel group, 6-keto-PGF1olevels were higher In the more centrally located vessels [arterial group: analysis of variance (ANOVA), F=23.9, p=0.0001 (aorta>lllac, p<0.015; Illaofemoral/carotld, p<0.0008; aorta>femoral/carotld, p<0.0002); venous group: ANOVA, F=15.3, p=0.0001 (IV O lilac, p<0.17, NS; Illaofemoral/jugular, p<0.005; IVC>femoral/]ugular, p<0.002)]. PGI2biosynthesis is greater In arterial endothellum than venous endothellum; K Is also greater In the arteries than In their corresponding veins. Within the arterial and venous systems, there is regional variability In PGI2production with greater activity In the more proximal or centrally located vessels, possibly In response to hemodynamlc differences, such as greater mean flow velocity and shear stress.
Arteriosclerosis – Wolters Kluwer Health
Published: May 1, 1989
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