Access the full text.
Sign up today, get DeepDyve free for 14 days.
Guinevere Lee, Nina Orlova-Fink, Kevin Einkauf, Fatema Chowdhury, Xiaoming Sun, S. Harrington, H. Kuo, S. Hua, Hsiao-Rong Chen, Zhengyu Ouyang, K. Reddy, K. Dong, T. Ndung’u, B. Walker, E. Rosenberg, Xu Yu, M. Lichterfeld (2017)
Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cellsJournal of Clinical Investigation, 127
Allison Thomas, K. Jones, R. Gandhi, R. Gandhi, D. McMahon, J. Cyktor, D. Chan, Szu-Han Huang, R. Truong, A. Bosque, A. Macedo, C. Kovacs, E. Benko, J. Eron, R. Bosch, C. Lalama, S. Simmens, B. Walker, B. Walker, B. Walker, J. Mellors, R. Jones (2017)
T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapyPLoS Pathogens, 13
Maldarelli (2014)
HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cellsScience, 345
R. Fromentin, Wendy Bakeman, M. Lawani, Gabriela Khoury, W. Hartogensis, S. DaFonseca, Marisela Killian, L. Epling, R. Hoh, E. Sinclair, F. Hecht, P. Bacchetti, S. Deeks, S. Lewin, R. Sékaly, N. Chomont (2016)
CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ARTPLoS Pathogens, 12
D. Planas, Yuwei Zhang, P. Monteiro, J. Goulet, A. Gosselin, N. Grandvaux, T. Hope, A. Fassati, J. Routy, P. Ancuța (2017)
HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms.JCI insight, 2 15
C. Kessing, Christopher Nixon, Chuan Li, Perry Tsai, H. Takata, H. Takata, G. Mousseau, P. Ho, J. Honeycutt, M. Fallahi, L. Trautmann, L. Trautmann, J. Garcia, S. Valente (2017)
In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a "Block-and-Lock" Strategy for HIV-1 Treatment.Cell reports, 21 3
B. Hiener, B. Horsburgh, John-Sebastian Eden, K. Barton, T. Schlub, Eunok Lee, S. Stockenstrom, L. Odevall, J. Milush, T. Liegler, E. Sinclair, R. Hoh, E. Boritz, D. Douek, R. Fromentin, N. Chomont, S. Deeks, F. Hecht, S. Palmer (2017)
Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants.Cell reports, 21 3
L. Shan, K. Deng, H. Gao, Sifei Xing, A. Capoferri, C. Durand, Alireza Rabi, G. Laird, Michelle Kim, Nina Hosmane, Hung‐Chih Yang, Hao Zhang, J. Margolick, Linghua Li, W. Cai, R. Ke, R. Flavell, J. Siliciano, R. Siliciano (2017)
Transcriptional Reprogramming during Effector‐to‐Memory Transition Renders CD4+ T Cells Permissive for Latent HIV‐1 InfectionImmunity, 47
R. Lorenzo-Redondo, H. Fryer, T. Bedford, Eun-Young Kim, J. Archer, Sergei Pond, Yoon-Seok Chung, Sudhir Penugonda, J. Chipman, C. Fletcher, T. Schacker, M. Malim, A. Rambaut, A. Haase, A. McLean, Steven Wolinsky (2015)
Persistent HIV-1 replication maintains the tissue reservoir during therapyNature, 530
(2017)
HIV persistence in tissue macrophages of humanized myeloid only mice during antiretroviral therapyNature medicine, 23
G. Dunay, A. Solomatina, S. Kummer, A. Hüfner, Julia Bialek, J. Eberhard, E. Tolosa, J. Hauber, J. Wiesch (2017)
Assessment of the HIV-1 reservoir in CD4+ regulatory T cells by a Droplet Digital PCR based approach.Virus research, 240
T. Henrich, Emily Hanhauser, F. Marty, M. Sirignano, S. Keating, Tzong-Hae Lee, Yvonne Robles, B. Davis, Jonathan Li, Andrea Heisey, A. Hill, M. Busch, P. Armand, R. Soiffer, M. Altfeld, D. Kuritzkes (2014)
Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell TransplantationAnnals of Internal Medicine, 161
C. McGary, C. Deleage, J. Harper, L. Micci, S. Ribeiro, S. Paganini, L. Kuri-Cervantes, Clarisse Benne, E. Ryan, R. Balderas, Sherrie Jean, Kirk Easley, V. Marconi, G. Silvestri, J. Estes, R. Sékaly, M. Paiardini (2017)
CTLA‐4+PD‐1− Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy‐Suppressed, SIV‐Infected Rhesus MacaquesImmunity, 47
H. Takata, S. Buranapraditkun, C. Kessing, J. Fletcher, Roshell Muir, V. Tardif, P. Cartwright, C. Vandergeeten, Wendy Bakeman, C. Nichols, S. Pinyakorn, P. Hansasuta, E. Kroon, T. Chalermchai, R. O’Connell, Jerome Kim, N. Phanuphak, M. Robb, N. Michael, N. Chomont, E. Haddad, J. Ananworanich, L. Trautmann (2017)
Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infectionScience Translational Medicine, 9
Daniel Rosenbloom, A. Hill, S. Laskey, R. Siliciano (2017)
Re-evaluating evolution in the HIV reservoirNature, 551
N. Cummins, A. Sainski‐Nguyen, S. Natesampillai, Fatma Aboulnasr, S. Kaufmann, A. Badley (2017)
Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 InhibitionJournal of Virology, 91
A. Gosselin, Tomas Salinas, D. Planas, V. Wacleche, Yuwei Zhang, R. Fromentin, N. Chomont, É. Cohen, B. Shacklett, V. Mehraj, M. Ghali, J. Routy, P. Ancuța (2016)
HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapyAIDS (London, England), 31
Kearney (2017)
Ongoing HIV replication during ART reconsideredOpen Forum Infect Dis, 4
Nina Hosmane, K. Kwon, Katherine Bruner, A. Capoferri, Subul Beg, Daniel Rosenbloom, B. Keele, Y. Ho, J. Siliciano, R. Siliciano (2017)
Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamicsThe Journal of Experimental Medicine, 214
I. Rouzine, Ariel Weinberger, L. Weinberger (2015)
An Evolutionary Role for HIV Latency in Enhancing Viral TransmissionCell, 160
N. Sebastian, T. Zaikos, V. Terry, F. Taschuk, L. McNamara, A. Onafuwa-Nuga, Ryan Yucha, Robert Signer, J. Riddell, D. Bixby, N. Markowitz, S. Morrison, K. Collins (2017)
CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivoPLoS Pathogens, 13
John Bui, M. Sobolewski, B. Keele, J. Spindler, Andrew Musick, A. Wiegand, B. Luke, W. Shao, S. Hughes, J. Coffin, Mary Kearney, J. Mellors (2017)
Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoirPLoS Pathogens, 13
Lenard Vranckx, J. Demeulemeester, Suha Saleh, Annegret Boll, Gerlinde Vansant, R. Schrijvers, C. Weydert, E. Battivelli, E. Verdin, A. Cereseto, F. Christ, R. Gijsbers, Z. Debyser (2016)
LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIVEBioMedicine, 8
J. Estes, C. Kityo, F. Ssali, L. Swainson, Krystelle Makamdop, G. Prete, S. Deeks, P. Luciw, J. Chipman, G. Beilman, Torfi Hoskuldsson, A. Khoruts, Jodi Anderson, C. Deleage, Jake Jasurda, Thomas Schmidt, Michael Hafertepe, Samuel Callisto, H. Pearson, Thomas Reimann, Jared Schuster, Jordan Schoephoerster, P. Southern, K. Perkey, L. Shang, S. Wietgrefe, C. Fletcher, J. Lifson, D. Douek, J. McCune, A. Haase, T. Schacker (2017)
Defining total-body AIDS-virus burden with implications for curative strategiesNature Medicine, 23
J. Grau-Expósito, Carla Serra-Peinado, L. Miguel, J. Navarro, A. Curran, J. Burgos, I. Ocaña, E. Ribera, A. Torrella, B. Planas, R. Badia, J. Castellví, V. Falcó, M. Crespo, M. Buzón (2017)
A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4+ T cells as a Major Niche for HIV-1 Transcription in HIV-Infected PatientsmBio, 8
C. Passaes, T. Bruel, J. Decalf, A. David, M. Angin, V. Monceaux, M. Muller-Trutwin, N. Noel, K. Bourdic, O. Lambotte, M. Albert, D. Duffy, O. Schwartz, A. Sáez-Cirión (2017)
Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal AgentsJournal of Virology, 91
Phalguni Gupta, Anwesha Sanyal, D. Ratner, M. Ding, J. Zerbato, Nicholas Giacobbi, Narasimhan Venkatachari, B. Patterson, Amanda Chargin, Yue Chen, R. Mailliard, C. Rinaldo, N. Sluis-Cremer (2017)
Novel assay reveals a large inducible replication competent HIV-1 reservoir in resting CD4+ T cellsNature medicine, 23
A. Baxter, J. Niessl, R. Fromentin, J. Richard, F. Porichis, Roxanne Charlebois, M. Massanella, N. Brassard, Nirmin Alsahafi, G. Delgado, J. Routy, B. Walker, A. Finzi, N. Chomont, D. Kaufmann (2016)
Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.Cell host & microbe, 20 3
Ross Pollack, R. Jones, M. Perțea, Katherine Bruner, Alyssa Martin, Allison Thomas, A. Capoferri, A. Capoferri, Subul Beg, Subul Beg, Szu-Han Huang, S. Karandish, Haiping Hao, E. Halper-Stromberg, Patrick Yong, C. Kovacs, E. Benko, R. Siliciano, R. Siliciano, Y. Ho (2017)
Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.Cell host & microbe, 21 4
Guangming Li, Jun-ichi Nunoya, L. Cheng, Natalia Reszka-Blanco, Li-Chung Tsao, J. Jeffrey, L. Su (2017)
Regulatory T Cells Contribute to HIV-1 Reservoir Persistence in CD4+ T Cells Through Cyclic Adenosine Monophosphate–Dependent Mechanisms in Humanized Mice In VivoThe Journal of Infectious Diseases, 216
Emily Cartwright, Lori Spicer, S. Smith, David Lee, R. Fast, S. Paganini, B. Lawson, M. Nega, Kirk Easley, J. Schmitz, S. Bosinger, M. Paiardini, A. Chahroudi, T. Vanderford, J. Estes, J. Lifson, C. Derdeyn, G. Silvestri (2016)
CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy.Immunity, 45 3
Y. Ho, L. Shan, Nina Hosmane, Jeffrey Wang, S. Laskey, Daniel Rosenbloom, J. Lai, J. Blankson, J. Siliciano, R. Siliciano (2013)
Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 CureCell, 155
N. Archin, J. Kirchherr, J. Sung, G. Clutton, K. Sholtis, Yinyan Xu, B. Allard, E. Stuelke, A. Kashuba, J. Kuruc, J. Eron, C. Gay, N. Goonetilleke, D. Margolis (2017)
Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latencyJournal of Clinical Investigation, 127
E. Boritz, S. Darko, L. Swaszek, G. Wolf, D. Wells, Xiaolin Wu, Amy Henry, Farida Laboune, Jianfei Hu, D. Ambrozak, M. Hughes, R. Hoh, J. Casazza, A. Vostal, D. Bunis, Krystelle Nganou-Makamdop, James Lee, S. Migueles, R. Koup, M. Connors, S. Moir, T. Schacker, F. Maldarelli, S. Hughes, S. Deeks, D. Douek (2016)
Multiple Origins of Virus Persistence during Natural Control of HIV InfectionCell, 166
(2017)
Regulatory T cells contribute to HIV-1 reservoir persistence in CD4 T cells through cAMP-dependent mechanisms in humanized mice in vivo
Guoxin Wu, M. Swanson, A. Talla, D. Graham, J. Strizki, D. Gorman, Richard Barnard, W. Blair, O. Søgaard, M. Tolstrup, L. Østergaard, T. Rasmussen, R. Sékaly, N. Archin, D. Margolis, D. Hazuda, B. Howell (2017)
HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal.JCI insight, 2 16
B. Descours, G. Petitjean, José-Luis López-Zaragoza, T. Bruel, Raoul Raffel, C. Psomas, J. Reynes, C. Lacabaratz, Y. Lévy, O. Schwartz, J. Lelièvre, M. Benkirane (2017)
CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent provirusesNature, 543
N. Cummins, S. Rizza, M. Litzow, S. Hua, Guinevere Lee, Kevin Einkauf, T. Chun, F. Rhame, J. Baker, M. Busch, N. Chomont, P. Dean, R. Fromentin, A. Haase, D. Hampton, S. Keating, S. Lada, Tzong-Hae Lee, S. Natesampillai, D. Richman, T. Schacker, S. Wietgrefe, Xu Yu, J. Yao, J. Zeuli, M. Lichterfeld, A. Badley (2017)
Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case studyPLoS Medicine, 14
Line Vibholm, M. Schleimann, J. Højen, T. Benfield, Rasmus Offersen, K. Rasmussen, R. Olesen, A. Dige, J∅rgen Agnholt, Judith Grau, M. Buzón, B. Wittig, M. Lichterfeld, A. Petersen, Xutao Deng, M. Abdel-Mohsen, S. Pillai, S. Rutsaert, Wim Trypsteen, W. Spiegelaere, Linos Vandekerchove, L. Østergaard, T. Rasmussen, P. Denton, M. Tolstrup, O. Søgaard (2017)
Short-Course Toll-Like Receptor 9 Agonist Treatment Impacts Innate Immunity and Plasma Viremia in Individuals With Human Immunodeficiency Virus InfectionClinical Infectious Diseases, 64
G. Martrus, Annika Niehrs, R. Cornelis, A. Rechtien, W. García-Beltrán, M. Lutgehetmann, Christian Hoffmann, M. Altfeld (2016)
Kinetics of HIV-1 Latency Reversal Quantified on the Single-Cell Level Using a Novel Flow-Based TechniqueJournal of Virology, 90
Riddhima Banga, F. Procopio, A. Noto, G. Pollakis, M. Cavassini, K. Ohmiti, J. Corpataux, L. Leval, G. Pantaleo, M. Perreau (2016)
PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individualsNature Medicine, 22
F. Maldarelli, Xiaolin Wu, Ling Su, F. Simonetti, D. Wells, W. Shao, J. Spindler, Andrea Ferris, J. Mellors, Mary Kearney, J. Coffin, S. Hughes (2016)
B-108 Specific HIV integration sites are linked to clonal expansion and persistence of infected cellsJAIDS Journal of Acquired Immune Deficiency Syndromes
A. Fun, H. Mok, M. Wills, A. Lever (2017)
A highly reproducible quantitative viral outgrowth assay for the measurement of the replication-competent latent HIV-1 reservoirScientific Reports, 7
Katherine Bruner, Alexandra Murray, Ross Pollack, M. Soliman, S. Laskey, A. Capoferri, J. Lai, M. Strain, S. Lada, R. Hoh, Y. Ho, D. Richman, S. Deeks, J. Siliciano, R. Siliciano (2016)
Defective proviruses rapidly accumulate during acute HIV-1 infectionNature medicine, 22
J. Sung, K. Sholtis, J. Kirchherr, J. Kuruc, C. Gay, J. Nordstrom, C. Bollard, N. Archin, D. Margolis (2017)
Vorinostat Renders the Replication-Competent Latent Reservoir of Human Immunodeficiency Virus (HIV) Vulnerable to Clearance by CD8 T CellsEBioMedicine, 23
T. Henrich, Kristen Hobbs, Emily Hanhauser, E. Scully, Louise Hogan, Yvonne Robles, Kaitlyn Leadabrand, F. Marty, Christine Palmer, S. Jost, C. Körner, Jonathan Li, R. Gandhi, A. Hamdan, J. Abramson, A. LaCasce, D. Kuritzkes (2017)
Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for MalignancyThe Journal of Infectious Diseases, 216
S. Leth, M. Schleimann, S. Nissen, J. Højen, R. Olesen, Mette Graversen, S. Jørgensen, A. Kjær, P. Denton, A. Mørk, M. Sommerfelt, K. Krogsgaard, L. Østergaard, T. Rasmussen, M. Tolstrup, O. Søgaard (2016)
Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial.The lancet. HIV, 3 10
M. Perreau, A. Savoye, E. Crignis, J. Corpataux, R. Cubas, E. Haddad, L. Leval, C. Graziosi, G. Pantaleo (2013)
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and productionThe Journal of Experimental Medicine, 210
Alyssa Martin, Ross Pollack, A. Capoferri, R. Ambinder, C. Durand, R. Siliciano (2017)
Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicityJournal of Clinical Investigation, 127
Heng-Chang Chen, J. Martinez, E. Zorita, A. Meyerhans, Guillaume Filion (2016)
Position effects influence HIV latency reversalNature Structural &Molecular Biology, 24
Purpose of reviewReservoirs of HIV-1-infected cells persist long-term despite highly effective antiretroviral suppression therapy and represent the main barrier against a cure for HIV-1. This review summarizes recent advances in understanding the complexity and diversity of viral reservoir cells.Recent findingsLatently infected memory CD4 T cells are the predominant cell compartment responsible for viral persistence, but some studies suggest that myeloid cells, and possibly hematopoietic progenitors, can also serve as long-term viral reservoirs. Specific phenotypic markers, including T-cell activation and exhaustion molecules, may denote CD4 T cells enriched for replication-competent proviruses. Clonal proliferation of infected CD4 T cells in vivo represents an important mechanism responsible for the remarkable long-term stability of the viral reservoir. Multiple new assays, including near full-genome proviral sequencing and simplified versions of viral outgrowth assays, are being developed to analyze and quantify persisting reservoirs of HIV-1-infected cells.SummaryRecent technological advances allow to profile the molecular structure and composition of viral reservoir cells in great detail. Continuous progress in understanding phenotypic and functional properties of viral reservoir cells provides clues for novel clinical interventions to destabilize viral persistence during antiretroviral therapy.
Current Opinion in HIV and Aids – Wolters Kluwer Health
Published: Mar 1, 2018
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.