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Recent Insights Into the Regulation of Coagulation and Thrombosis

Recent Insights Into the Regulation of Coagulation and Thrombosis Arteriosclerosis, Thrombosis, and Vascular Biology RECENT HIGHLIGHTS OF ATVB Recent Insights Into the Regulation of Coagulation and Thrombosis Xian Li, Martha M.S. Sim, Jeremy P. Wood emostatic clot formation is the result of a balance levels of TF. These cells might also release TF into the between the procoagulant system responding to circulation, either as the soluble extracellular form or Htissue trauma and the anticoagulant system, which as full-length protein incorporated into microvesicles. restricts clot formation to the injury site. Imbalances in Recent studies have identified additional mechanisms coagulation lead to a tendency towards either thrombo- regulating TF expression. Neutrophils can release neu- sis or bleeding. Over the past 2 years, studies published trophil extracellular traps, which consist of DNA, histones, in Arteriosclerosis, Thrombosis, and Vascular Biology have and granular enzymes, and Folco et al showed that neu- provided insights into the regulation of this crucial sys- trophil extracellular trap-associated effectors induce tem. Here, we highlight recent discoveries concerning endothelial cell expression of TF through an interleukin the 2 pathways of thrombin formation, the extrinsic TF 1α and cathepsin G-dependent pathway. According to a (tissue factor) pathway and the intrinsic contact pathway, recent study by Liang et al, the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis, Thrombosis, and Vascular Biology Wolters Kluwer Health

Recent Insights Into the Regulation of Coagulation and Thrombosis

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Publisher
Wolters Kluwer Health
Copyright
© 2020 American Heart Association, Inc.
ISSN
1079-5642
eISSN
1524-4636
DOI
10.1161/ATVBAHA.120.312674
Publisher site
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Abstract

Arteriosclerosis, Thrombosis, and Vascular Biology RECENT HIGHLIGHTS OF ATVB Recent Insights Into the Regulation of Coagulation and Thrombosis Xian Li, Martha M.S. Sim, Jeremy P. Wood emostatic clot formation is the result of a balance levels of TF. These cells might also release TF into the between the procoagulant system responding to circulation, either as the soluble extracellular form or Htissue trauma and the anticoagulant system, which as full-length protein incorporated into microvesicles. restricts clot formation to the injury site. Imbalances in Recent studies have identified additional mechanisms coagulation lead to a tendency towards either thrombo- regulating TF expression. Neutrophils can release neu- sis or bleeding. Over the past 2 years, studies published trophil extracellular traps, which consist of DNA, histones, in Arteriosclerosis, Thrombosis, and Vascular Biology have and granular enzymes, and Folco et al showed that neu- provided insights into the regulation of this crucial sys- trophil extracellular trap-associated effectors induce tem. Here, we highlight recent discoveries concerning endothelial cell expression of TF through an interleukin the 2 pathways of thrombin formation, the extrinsic TF 1α and cathepsin G-dependent pathway. According to a (tissue factor) pathway and the intrinsic contact pathway, recent study by Liang et al, the

Journal

Arteriosclerosis, Thrombosis, and Vascular Biology – Wolters Kluwer Health

Published: May 1, 2020

References

  • Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.
    Drake TA