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Reaction Patterns of TRAP and DBA.44 in Hairy Cell Leukemia, Hairy Cell Variant, and Nodal and Extranodal Marginal Zone B-cell Lymphomas

Reaction Patterns of TRAP and DBA.44 in Hairy Cell Leukemia, Hairy Cell Variant, and Nodal and... RESEARCH ARTICLE Reaction Patterns of TRAP and DBA.44 in Hairy Cell Leukemia, Hairy Cell Variant, and Nodal and Extranodal Marginal Zone B-cell Lymphomas Cherie H. Dunphy, MD airy cell leukemia (HCL) is a neoplasm of small B Context: The differential diagnosis of hairy cell leukemia (HCL) Hlymphoid cells with oval (or kidney-bean shaped) includes HC variant (HC-V) and marginal zone lymphoma nuclei associated with abundant cytoplasm with ‘‘hairy’’ (MZL). There is a high sensitivity of combined DBA.44/TRAP- projections in bone marrow (BM) and peripheral blood, positivity (+) in confirming HCL. A previous study of mucosa- diffusely infiltrating BM and splenic red pulp, and associated lymphoid tissue lymphoma showed DBA.44+ in strongly expressing CD103, CD22, and CD11c. The 10%, TRAP+ in 29%, and DBA.44+/TRAP+ in 5%. exact subset of B cells from which hairy cells are derived, is still unclear. However, previous studies have suggested Objective: We now study nodal MZL (NMZL) and HC-V. origination of hairy cells from the B lymphocytes Design: Two HCL, 2 HC-V, 3 MZL of bone marrow (BM), normally residing in the marginal zone of the splenic 2 MZL versus B-cell lymphoma, not otherwise specified (BCL, 2,3 white pulp. NOS) of BM, and 4 NMZL http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Reaction Patterns of TRAP and DBA.44 in Hairy Cell Leukemia, Hairy Cell Variant, and Nodal and Extranodal Marginal Zone B-cell Lymphomas

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References (17)

ISSN
1541-2016
DOI
10.1097/PAI.0b013e3180471fd4
pmid
18227730
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Reaction Patterns of TRAP and DBA.44 in Hairy Cell Leukemia, Hairy Cell Variant, and Nodal and Extranodal Marginal Zone B-cell Lymphomas Cherie H. Dunphy, MD airy cell leukemia (HCL) is a neoplasm of small B Context: The differential diagnosis of hairy cell leukemia (HCL) Hlymphoid cells with oval (or kidney-bean shaped) includes HC variant (HC-V) and marginal zone lymphoma nuclei associated with abundant cytoplasm with ‘‘hairy’’ (MZL). There is a high sensitivity of combined DBA.44/TRAP- projections in bone marrow (BM) and peripheral blood, positivity (+) in confirming HCL. A previous study of mucosa- diffusely infiltrating BM and splenic red pulp, and associated lymphoid tissue lymphoma showed DBA.44+ in strongly expressing CD103, CD22, and CD11c. The 10%, TRAP+ in 29%, and DBA.44+/TRAP+ in 5%. exact subset of B cells from which hairy cells are derived, is still unclear. However, previous studies have suggested Objective: We now study nodal MZL (NMZL) and HC-V. origination of hairy cells from the B lymphocytes Design: Two HCL, 2 HC-V, 3 MZL of bone marrow (BM), normally residing in the marginal zone of the splenic 2 MZL versus B-cell lymphoma, not otherwise specified (BCL, 2,3 white pulp. NOS) of BM, and 4 NMZL

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Mar 1, 2008

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