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M. Mourtada-Maarabouni, L. Sutherland, J. Meredith, G.T. Williams (2003)
Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta‐6 of the candidate tumour suppressor LUCA‐15/RBM5Genes to Cells, 8
F. Buttitta, Fabio Barassi, Giuseppina Fresu, L. Felicioni, A. Chella, Diego Paolizzi, G. Lattanzio, S. Salvatore, P. Camplese, S. Rosini, T. Iarussi, F. Mucilli, R. Sacco, A. Mezzetti, A. Marchetti (2006)
Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: Mutations are mainly present in adenocarcinomas with bronchioloalveolar featuresInternational Journal of Cancer, 119
M. Mourtada-Maarabouni, L. Sutherland, L. Sutherland, G.T. Williams (2002)
Candidate tumour suppressor LUCA-15 can regulate multiple apoptotic pathwaysApoptosis, 7
J. Oh, Ali Razfar, Idolina Delgado, Rebecca Reed, A. Malkina, Baher Boctor, D. Slamon (2006)
3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis.Cancer research, 66 7
Giovanni Carboni, B. Gao, M. Nishizaki, Kai Xu, J. Minna, J. Roth, L. Ji (2003)
CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrityOncogene, 22
A. Gazdar, H. Shigematsu, J. Herz, J. Minna (2004)
Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?Trends in molecular medicine, 10 10
L. Sutherland, M. Lerman, Gwyn Williams, B. Miller (2004)
LUCA-15 suppresses CD95-mediated apoptosis in Jurkat T cellsOncogene, 23
S. Bonnal, C. Martínez, P. Förch, A. Bachi, M. Wilm, J. Valcárcel (2008)
RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition.Molecular cell, 32 1
A. Elst, Bea Hiemstra, P. Vlies, Wytske Kamminga, A. Veen, Inge Davelaar, P. Terpstra, G. Meerman, F. Gerbens, K. Kok, C. Buys (2006)
Functional analysis of lung tumor suppressor activity at 3p21.3Genes, 45
K. Fushimi, P. Ray, Amar Kar, Lei Wang, L. Sutherland, Jane Wu (2008)
Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5Proceedings of the National Academy of Sciences, 105
Emely Castro-Rivera, S. Ran, P. Thorpe, J. Minna (2004)
Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect.Proceedings of the National Academy of Sciences of the United States of America, 101 31
J. Oh, Baher Boctor, C. Jimenez, R. Lopez, A. Koegel, Eileen Taschereau, Diana Phan, S. Jacobsen, D. Slamon (2008)
Promoter methylation study of the H37/RBM5 tumor suppressor gene from the 3p21.3 human lung cancer tumor suppressor locusHuman Genetics, 123
Nack Bae, M. Chae, Myung‐Hoon Lee, Kyung Kim, E. Lee, C. Kim, T. Park, S. Han, S. Jheon, T. Jung, J. Park (2007)
EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients.Cancer genetics and cytogenetics, 173 2
M. Lerman, J. Minna (2000)
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.Cancer research, 60 21
Nina Rintala-Maki, L. Sutherland (2009)
Identification and characterisation of a novel antisense non-coding RNA from the RBM5 gene locus.Gene, 445 1-2
Ke Wang, Gino Ubriaco, L. Sutherland (2007)
RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumoursBMC Genomics, 8
A. Agathanggelou, I. Bièche, J. Ahmed-Choudhury, B. Nicke, R. Dammann, S. Baksh, B. Gao, J. Minna, J. Downward, E. Maher, F. Latif (2003)
Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma.Cancer research, 63 17
L. Sutherland, S. Edwards, H. Cable, G. Poirier, B. Miller, C. Cooper, Gwyn Williams (2000)
LUCA-15-encoded sequence variants regulate CD95-mediated apoptosisOncogene, 19
E. Zabarovsky, M. Lerman, J. Minna (2002)
Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancersOncogene, 21
J. Oh, A. Koegel, Diana Phan, Ali Razfar, D. Slamon (2007)
The two single nucleotide polymorphisms in the H37/RBM5 tumour suppressor gene at 3p21.3 correlated with different subtypes of non-small cell lung cancers.Lung cancer, 58 1
Nina Rintala-Maki, C. Goard, Colleen Langdon, Vanessa Wall, K. Traulsen, Cory Morin, M. Bonin, L. Sutherland (2007)
Expression of RBM5‐related factors in primary breast tissueJournal of Cellular Biochemistry, 100
S. Toyooka, R. Maruyama, K. Toyooka, D. McLerran, Ziding Feng, Y. Fukuyama, A. Virmani, Sabine Zochbauer-Muller, K. Tsukuda, K. Sugio, N. Shimizu, K. Shimizu, Hue Lee, Chih‐Yi Chen, K. Fong, M. Gilcrease, J. Roth, J. Minna, A. Gazdar (2003)
Smoke exposure, histologic type and geography‐related differences in the methylation profiles of non‐small cell lung cancerInternational Journal of Cancer, 103
H. Edamatsu, Y. Kaziro, H. Itoh (2000)
LUCA15, a putative tumour suppressor gene encoding an RNA‐binding nuclear protein, is down‐regulated in ras‐transformed Rat‐1 cellsGenes to Cells, 5
Sridhar Ramaswamy, K. Ross, E. Lander, T. Golub (2003)
A molecular signature of metastasis in primary solid tumorsNature Genetics, 33
K. Kok, S. Naylor, C. Buys (1997)
Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes.Advances in cancer research, 71
T. Qiu, G. Chandramouli, K. Hunter, Nawal Alkharouf, Jeffrey Green, E. Liu (2004)
Global Expression Profiling Identifies Signatures of Tumor Virulence in MMTV-PyMT-Transgenic MiceCancer Research, 64
F. Hirsch, W. Franklin, R. Veve, M. Varella-Garcia, P. Bunn (2002)
HER2/neu expression in malignant lung tumors.Seminars in oncology, 29 1 Suppl 4
Y. Sekido, M. Ahmadian, I. Wistuba, F. Latif, S. Bader, M. Wei, F. Duh, A. Gazdar, M. Lerman, J. Minna (1998)
Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor geneOncogene, 16
K. Viktorsson, R. Lewensohn (2007)
Apoptotic signaling pathways in lung cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2 3
L. Ji, J. Minna, J. Roth (2005)
3p21.3 tumor suppressor cluster: prospects for translational applications.Future oncology, 1 1
Nina Rintala-Maki, Virginia Abrasonis, M. Burd, L. Sutherland (2004)
Genetic instability of RBM5/LUCA‐15/H37 in MCF‐7 breast carcinoma sublines may affect susceptibility to apoptosisCell Biochemistry and Function, 22
M. Wei, F. Latif, S. Bader, V. Kashuba, J. Chen, F. Duh, Y. Sekido, Cheng Lee, L. Geil, I. Kuzmin, E. Zabarovsky, G. Klein, B. Zbar, J. Minna, M. Lerman (1996)
Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG.Cancer research, 56 7
L. Ji, J. Roth (2008)
Tumor suppressor FUS1 signaling pathway.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 3 4
I. Wistuba, C. Behrens, A. Virmani, Gina Mele, S. Milchgrub, L. Girard, J. Fondon, H. Garner, Bruce McKay, F. Latif, M. Lerman, S. Lam, A. Gazdar, J. Minna (2000)
High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.Cancer research, 60 7
S. Todd, W. Franklin, M. Varella-Garcia, T. Kennedy, C. Hilliker, L. Hahner, Marshall Anderson, J. Wiest, H. Drabkin, R. Gemmill (1997)
Homozygous deletions of human chromosome 3p in lung tumors.Cancer research, 57 7
V. Senchenko, Jian Liu, W. Loginov, I. Bazov, D. Angeloni, Y. Seryogin, V. Ermilova, T. Kazubskaya, R. Garkavtseva, V. Zabarovska, V. Kashuba, L. Kisselev, J. Minna, M. Lerman, G. Klein, E. Braga, E. Zabarovsky (2004)
Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomasOncogene, 23
T. Timmer, P. Terpstra, A. Berg, P. Veldhuis, A. Elst, G. Voutsinas, M. Hulsbeek, T. Draaijers, M. Looman, K. Kok, S. Naylor, C. Buys (1999)
A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3European Journal of Human Genetics, 7
Nina Rintala-Maki, L. Sutherland (2004)
LUCA-15/RBM5, a putative tumour suppressor, enhances multiple receptor-initiated death signalsApoptosis, 9
(2000)
3 p 21 . 3 Tumor Suppressor Gene Consortium
J. Oh, Alison West, M. Fishbein, D. Slamon (2002)
A candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3.Cancer research, 62 11
O. Canoz, M. Ozkan, Vedat Arsav, O. Er, H. Coskun, S. Soyuer, M. Altınbaş (2006)
The Role of c-erbB-2 Expression on the Survival of Patients with Small-Cell Lung CancerLung, 184
PATHWAY OF THE MONTH RBM5 as a Putative Tumor Suppressor Gene for Lung Cancer Leslie C. Sutherland, PhD,*†‡ Ke Wang, MD, PhD,§ and Andrew G. Robinson, MD tumors, the majority (70%) of non-SCLC (NSCLC) tumors, Abstract: RBM5 is one member of a group of structurally related genes and in the normal bronchial epithelium of some smokers and that includes RBM6 and RBM10. RBM10 maps to Xp11.23, and one 2– 4 former smokers. The smallest lung cancer-specific deletion allele is inactivated as a result of X chromosome inactivation. Both region (based on homozygous deletion studies relating to 3 RBM5 and RBM6 map to 3p21.3, a tumor suppressor region that established SCLC cell lines (GLC20, NCI-H740, and NCI- experiences loss of heterozygosity in the majority of lung cancers. H1450) spans 370 kb, 19 genes (RBM6, RBM5, SEMA3F, Overexpression of RBM5, which encodes an RNA-binding protein GNAT1, NAT1/SLC38A3/G17, GNAI2, SEMA3B, IFRD2, involved in the regulation of alternative splicing and retards ascites HYAL3, FUS2/NAT6, HYAL1, HYAL2, FUS1/TUSC2, associated tumor growth in immunocompromised mice, a phenomenon RASSF1/123F2, BLU/ZMYND10, NPRL2/TUSC4, 101F6/ that may be related to an associated ability to modulate apoptosis. As TSP10/CYB561D2, PL6/TMEM115, and CACNA2D2), and part of our quest to gain a
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Mar 1, 2010
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