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Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting Mycobacterium Tuberculosis

Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting... RESEARCH ARTICLE Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting Mycobacterium Tuberculosis Complex Specific Antigen MPT64 in Patients From a HIV Endemic Area Kamaldeen Baba, MD,*w z Anne Margarita Dyrhol-Riise, MD, PhD,*y Lisbet Sviland, MD, PhD,w J Nina Langeland, MD, PhD,*y Anwar A. Hoosen, MD,z Harald G. Wiker, MD, PhD,z and Tehmina Mustafa, MD, PhDwz Key Words: Tuberculous pleuritis, HIV, MPT64, diagnosis, Aim: The aim of the study was to evaluate the diagnostic immunohistochemistry, PCR potential of immunohistochemistry using an antibody to the (Appl Immunohistochem Mol Morphol 2008;16:554–561) secreted mycobacterial antigen MPT64, specific for Mycobac- terium tuberculosis complex organisms, on formalin-fixed biopsies from patients with pleural tuberculosis (TB) from a high TB and HIV endemic area. uberculosis (TB) is a major global burden with an Testimated 8-9 million new cases of TB annually. In Methods and Results: Pleural biopsies from 25 TB cases and 11 many parts of the world, the increase in prevalence is non-TB cases were studied. Ziehl-Neelsen staining for acid-fast driven by the HIV-1 epidemic and in South Africa, 61% bacilli and immunohistochemistry with anti-MPT64 and anti- of adult TB cases are HIV-1 positive and 25% of new TB Bacille Calmette-Gue´ rin (BCG) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting Mycobacterium Tuberculosis

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e31816c3f79
pmid
18698260
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting Mycobacterium Tuberculosis Complex Specific Antigen MPT64 in Patients From a HIV Endemic Area Kamaldeen Baba, MD,*w z Anne Margarita Dyrhol-Riise, MD, PhD,*y Lisbet Sviland, MD, PhD,w J Nina Langeland, MD, PhD,*y Anwar A. Hoosen, MD,z Harald G. Wiker, MD, PhD,z and Tehmina Mustafa, MD, PhDwz Key Words: Tuberculous pleuritis, HIV, MPT64, diagnosis, Aim: The aim of the study was to evaluate the diagnostic immunohistochemistry, PCR potential of immunohistochemistry using an antibody to the (Appl Immunohistochem Mol Morphol 2008;16:554–561) secreted mycobacterial antigen MPT64, specific for Mycobac- terium tuberculosis complex organisms, on formalin-fixed biopsies from patients with pleural tuberculosis (TB) from a high TB and HIV endemic area. uberculosis (TB) is a major global burden with an Testimated 8-9 million new cases of TB annually. In Methods and Results: Pleural biopsies from 25 TB cases and 11 many parts of the world, the increase in prevalence is non-TB cases were studied. Ziehl-Neelsen staining for acid-fast driven by the HIV-1 epidemic and in South Africa, 61% bacilli and immunohistochemistry with anti-MPT64 and anti- of adult TB cases are HIV-1 positive and 25% of new TB Bacille Calmette-Gue´ rin (BCG)

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Dec 1, 2008

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