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RESEARCH ARTICLE Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting Mycobacterium Tuberculosis Complex Specific Antigen MPT64 in Patients From a HIV Endemic Area Kamaldeen Baba, MD,*w z Anne Margarita Dyrhol-Riise, MD, PhD,*y Lisbet Sviland, MD, PhD,w J Nina Langeland, MD, PhD,*y Anwar A. Hoosen, MD,z Harald G. Wiker, MD, PhD,z and Tehmina Mustafa, MD, PhDwz Key Words: Tuberculous pleuritis, HIV, MPT64, diagnosis, Aim: The aim of the study was to evaluate the diagnostic immunohistochemistry, PCR potential of immunohistochemistry using an antibody to the (Appl Immunohistochem Mol Morphol 2008;16:554–561) secreted mycobacterial antigen MPT64, specific for Mycobac- terium tuberculosis complex organisms, on formalin-fixed biopsies from patients with pleural tuberculosis (TB) from a high TB and HIV endemic area. uberculosis (TB) is a major global burden with an Testimated 8-9 million new cases of TB annually. In Methods and Results: Pleural biopsies from 25 TB cases and 11 many parts of the world, the increase in prevalence is non-TB cases were studied. Ziehl-Neelsen staining for acid-fast driven by the HIV-1 epidemic and in South Africa, 61% bacilli and immunohistochemistry with anti-MPT64 and anti- of adult TB cases are HIV-1 positive and 25% of new TB Bacille Calmette-Gue´ rin (BCG)
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Dec 1, 2008
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