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Randomized Controlled Trial of Topical Insulin for Healing Corneal Epithelial Defects Induced During Vitreoretinal Surgery in Diabetics

Randomized Controlled Trial of Topical Insulin for Healing Corneal Epithelial Defects Induced... Downloaded from http://journals.lww.com/apjoo by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/01/2020 ORIGINAL CLINICAL STUDY Randomized Controlled Trial of Topical Insulin for Healing Corneal Epithelial Defects Induced During Vitreoretinal Surgery in Diabetics Seng Fai, MD, Amin Ahem, DrOphth (UKM), Mushawiathi Mustapha, DrOphth (UKM), Umi Kalthum Mohd Noh, DrOphth (UKM), and Mae-Lynn Catherine Bastion, FRCS (Glasgow), DrOphth (UKM) Other corneal changes resulting from diabetes include neuropa- Purpose: To determine the effect of topical insulin of 3 concentrations thy and alterations in the corneal stroma, Descemet membrane, [0.5, 1, and 2 units per drop 4 times per day (QID)] on postoperative and corneal endothelium. The cornea of individuals with diabe- corneal epithelial wound healing in diabetic patients. tes could seem normal until the corneal surface is damaged and Design: A double blind randomized controlled hospital-based study in- epithelial healing is delayed. Sequelae can range from infectious volving diabetic patients with postoperative corneal epithelial defect after corneal ulcers to secondary corneal scarring and finally perma- vitreoretinal surgery. 3,4 nent loss of vision. Thus, rapid resurfacing of injured corneal Methods: Diabetic patients were randomized to 3 different concentra- epithelium is needed to reestablish corneal function. tions of topical insulin (DTI 0.5, DTI 1, and DTI 2) or placebo http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Asia-Pacific Journal of Ophthalmology Wolters Kluwer Health

Randomized Controlled Trial of Topical Insulin for Healing Corneal Epithelial Defects Induced During Vitreoretinal Surgery in Diabetics

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Publisher
Wolters Kluwer Health
ISSN
2162-0989
eISSN
2475-5028
DOI
10.22608/APO.201780
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/apjoo by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/01/2020 ORIGINAL CLINICAL STUDY Randomized Controlled Trial of Topical Insulin for Healing Corneal Epithelial Defects Induced During Vitreoretinal Surgery in Diabetics Seng Fai, MD, Amin Ahem, DrOphth (UKM), Mushawiathi Mustapha, DrOphth (UKM), Umi Kalthum Mohd Noh, DrOphth (UKM), and Mae-Lynn Catherine Bastion, FRCS (Glasgow), DrOphth (UKM) Other corneal changes resulting from diabetes include neuropa- Purpose: To determine the effect of topical insulin of 3 concentrations thy and alterations in the corneal stroma, Descemet membrane, [0.5, 1, and 2 units per drop 4 times per day (QID)] on postoperative and corneal endothelium. The cornea of individuals with diabe- corneal epithelial wound healing in diabetic patients. tes could seem normal until the corneal surface is damaged and Design: A double blind randomized controlled hospital-based study in- epithelial healing is delayed. Sequelae can range from infectious volving diabetic patients with postoperative corneal epithelial defect after corneal ulcers to secondary corneal scarring and finally perma- vitreoretinal surgery. 3,4 nent loss of vision. Thus, rapid resurfacing of injured corneal Methods: Diabetic patients were randomized to 3 different concentra- epithelium is needed to reestablish corneal function. tions of topical insulin (DTI 0.5, DTI 1, and DTI 2) or placebo

Journal

The Asia-Pacific Journal of OphthalmologyWolters Kluwer Health

Published: Sep 1, 2017

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