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Pseudosarcomatous Spindle Cell Proliferation With Osteoid Matrix Mimicking Osteosarcoma A Distinct Histologic Phenotype in Giant Cell Tumor of Bone Following Denosumab Therapy

Pseudosarcomatous Spindle Cell Proliferation With Osteoid Matrix Mimicking Osteosarcoma A... LETTER TO THE EDITOR Pseudosarcomatous Spindle Cell Proliferation With Osteoid Matrix Mimicking Osteosarcoma: A Distinct Histologic Phenotype in Giant Cell Tumor of Bone Following Denosumab Therapy Giant cell tumor of bone (GCTB) is a distinct benign locally aggressive neoplasm of bone composed of multi- nucleated osteoclast-type giant cells and round to oval or spindled mono- nuclear cells. It comprises 4% to 5% of all primary bone tumors and 18% to 20% of all benign bone tumors, and usually presents as osteolytic lesion of the bone with predilection for the epiphyses of long bones, often in skeletally mature individuals be- tween 20 and 50 years of age. Radio- graphically, it presents as an eccentric radiolucent lesion frequently involv- FIGURE 1. A, Pretreatment radiograph showing anteroposterior axis of left distal ra- ing the epiphyseal region of long dius demonstrating an expansile lytic lesion next to subchondral bone. B, Fine needle bone. The prototypic histopathology aspiration biopsy showing osteoclast-like giant cells and mononuclear round to oval includes a dense population of round stromal cells prototypic of giant cell tumor of bone (H&E; magnification: 200). C, to oval or spindled mononuclear cells Post-treatment radiograph showing anteroposterior axis of left distal radius demon- admixed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Pseudosarcomatous Spindle Cell Proliferation With Osteoid Matrix Mimicking Osteosarcoma A Distinct Histologic Phenotype in Giant Cell Tumor of Bone Following Denosumab Therapy

Iwenofu, Obiajulu H.
Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Mar 1, 2015
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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000165
pmid
25789537
Publisher site
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Abstract

LETTER TO THE EDITOR Pseudosarcomatous Spindle Cell Proliferation With Osteoid Matrix Mimicking Osteosarcoma: A Distinct Histologic Phenotype in Giant Cell Tumor of Bone Following Denosumab Therapy Giant cell tumor of bone (GCTB) is a distinct benign locally aggressive neoplasm of bone composed of multi- nucleated osteoclast-type giant cells and round to oval or spindled mono- nuclear cells. It comprises 4% to 5% of all primary bone tumors and 18% to 20% of all benign bone tumors, and usually presents as osteolytic lesion of the bone with predilection for the epiphyses of long bones, often in skeletally mature individuals be- tween 20 and 50 years of age. Radio- graphically, it presents as an eccentric radiolucent lesion frequently involv- FIGURE 1. A, Pretreatment radiograph showing anteroposterior axis of left distal ra- ing the epiphyseal region of long dius demonstrating an expansile lytic lesion next to subchondral bone. B, Fine needle bone. The prototypic histopathology aspiration biopsy showing osteoclast-like giant cells and mononuclear round to oval includes a dense population of round stromal cells prototypic of giant cell tumor of bone (H&E; magnification: 200). C, to oval or spindled mononuclear cells Post-treatment radiograph showing anteroposterior axis of left distal radius demon- admixed

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Mar 1, 2015

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