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Proton Magnetic Resonance Spectroscopy and Diffusion-Weighted Imaging of Central Nervous System Whipple Disease

Proton Magnetic Resonance Spectroscopy and Diffusion-Weighted Imaging of Central Nervous System... CASE REPORT Proton Magnetic Resonance Spectroscopy and Diffusion-Weighted Imaging of Central Nervous System Whipple Disease Jared W. Nelson, BS,* Matthew L. White, MD,† Yan Zhang, MD,† and Toshio Moritani, MD† Six months before admission, he began experiencing dizziness Summary: A 72-year-old man presented with a 6-month history of when bending over, difficulty with walking and balance, occasional gastrointestinal upset, and anorexia accompanied by food tasting odd. dysphagia, fatigue, 60-lb weight loss, and central nervous system For the next 2 months, these symptoms worsened, with the addition of (CNS) deficits. Diffusion-weighted magnetic resonance imaging (MRI) incoherent speech and progressive weakness and fatigue. He had not of the brain showed mildly elevated nonrestricted apparent diffusion yet, however, met with a physician concerning these problems. coefficients in the middle cerebellar peduncles, and magnetic resonance The patient presented to the local hospital when his previous spectroscopy (MRS) showed decreased N-acetylaspartate and creatine symptoms remained and he began to experience hoarseness, diplopia, with increased choline. Diffusion-weighted MRI and MRS offer non- and decreased eye movement. He was transferred to our hospital invasive methods to help evaluate in vivo physiologic changes of 1 week after initial admission. In addition to these findings, he had CNS http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Computer Assisted Tomography Wolters Kluwer Health

Proton Magnetic Resonance Spectroscopy and Diffusion-Weighted Imaging of Central Nervous System Whipple Disease

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Copyright
Copyright © 2005 by Lippincott Williams & Wilkins
ISSN
0363-8715
eISSN
1532-3145
DOI
10.1097/01.rct.0000163570.71758.92
Publisher site
See Article on Publisher Site

Abstract

CASE REPORT Proton Magnetic Resonance Spectroscopy and Diffusion-Weighted Imaging of Central Nervous System Whipple Disease Jared W. Nelson, BS,* Matthew L. White, MD,† Yan Zhang, MD,† and Toshio Moritani, MD† Six months before admission, he began experiencing dizziness Summary: A 72-year-old man presented with a 6-month history of when bending over, difficulty with walking and balance, occasional gastrointestinal upset, and anorexia accompanied by food tasting odd. dysphagia, fatigue, 60-lb weight loss, and central nervous system For the next 2 months, these symptoms worsened, with the addition of (CNS) deficits. Diffusion-weighted magnetic resonance imaging (MRI) incoherent speech and progressive weakness and fatigue. He had not of the brain showed mildly elevated nonrestricted apparent diffusion yet, however, met with a physician concerning these problems. coefficients in the middle cerebellar peduncles, and magnetic resonance The patient presented to the local hospital when his previous spectroscopy (MRS) showed decreased N-acetylaspartate and creatine symptoms remained and he began to experience hoarseness, diplopia, with increased choline. Diffusion-weighted MRI and MRS offer non- and decreased eye movement. He was transferred to our hospital invasive methods to help evaluate in vivo physiologic changes of 1 week after initial admission. In addition to these findings, he had CNS

Journal

Journal of Computer Assisted Tomography – Wolters Kluwer Health

Published: May 1, 2005

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