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Prostacyclin and Arterial Wall Biology

Prostacyclin and Arterial Wall Biology Review Salvador Moncada he discovery of prostacyclin has allowed new in- two other unstable products, prostacyclin (strong va- T depth investigations of platelet vessel wall inter- sodilator and inhibitor of platelet aggregation) and actions and their relationship to pathological condi- TXA^ (vasoconstrictor and platelet aggregator). Un- tions like thrombosis and atherosclerosis. This paper like PGE , D , or F these products are not formed reviews current research in prostacyclin and arterial by chemical breakdown of PGH . The cyclooxygen- wall biology. ase is inhibited by aspirin-like drugs leading to the hypothesis5 that the therapeutic, as well as the shared side-effects, of aspirin-like drugs are related Arachidonic Acid Metabolism to inhibition of prostaglandin biosynthesis. Since the publication of this data, a great deal of evidence has Arachidonic acid, the precursor of all bisenoic accumulated in favor of this proposal.6 prostaglandins, is the most common fatty acid pres- The lipoxygenase leads to the formation of eico- ent in cellular phospholipids and can be obtained sanoids, which are noncyclized hydroxy acids. 11 directly from the diet or by desaturation and chain and 15-hydroxyeicosatetraenoic acid (11 & 15- elongation from dietary linoleic acid (C18:2 w-6). HETE) may be formed as the result http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Prostacyclin and Arterial Wall Biology

Arteriosclerosis , Volume 2 (3) – May 1, 1982

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Copyright
© 1982 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

Review Salvador Moncada he discovery of prostacyclin has allowed new in- two other unstable products, prostacyclin (strong va- T depth investigations of platelet vessel wall inter- sodilator and inhibitor of platelet aggregation) and actions and their relationship to pathological condi- TXA^ (vasoconstrictor and platelet aggregator). Un- tions like thrombosis and atherosclerosis. This paper like PGE , D , or F these products are not formed reviews current research in prostacyclin and arterial by chemical breakdown of PGH . The cyclooxygen- wall biology. ase is inhibited by aspirin-like drugs leading to the hypothesis5 that the therapeutic, as well as the shared side-effects, of aspirin-like drugs are related Arachidonic Acid Metabolism to inhibition of prostaglandin biosynthesis. Since the publication of this data, a great deal of evidence has Arachidonic acid, the precursor of all bisenoic accumulated in favor of this proposal.6 prostaglandins, is the most common fatty acid pres- The lipoxygenase leads to the formation of eico- ent in cellular phospholipids and can be obtained sanoids, which are noncyclized hydroxy acids. 11 directly from the diet or by desaturation and chain and 15-hydroxyeicosatetraenoic acid (11 & 15- elongation from dietary linoleic acid (C18:2 w-6). HETE) may be formed as the result

Journal

ArteriosclerosisWolters Kluwer Health

Published: May 1, 1982

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