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Prophylactic antiretroviral regimens for prevention of mother-to- child transmission of HIV in resource-limited settings Elise Arrive´ and Franc ¸ois Dabis INSERM 593, Institute for Public Health, Epidemiology Purpose of review and Development (ISPED), Victor Segalen University, With the large international mobilization against HIV/AIDS, more HIV-infected people in Bordeaux, France resource-limited settings have access to antiretroviral therapy, including pregnant Correspondence to Dr Elise Arrive´, Unite´ INSERM 593, women. The relevance of simplified prophylactic antiretroviral regimens for the Institut de Sante´ Publique, Epide´miologie et De´veloppement (ISPED), Universite´ Victor Segalen prevention of mother-to-child transmission of HIV may become questionable due to their Bordeaux 2, 146, rue Le´o Saignat, 33076 lower efficacy and their higher risk of inducing viral resistance than fully suppressive BORDEAUX Cedex, France Tel: +33 5 5757 4810; fax: +33 5 5757 4528; antiretroviral therapy. e-mail: Elise.arrive@isped.u-bordeaux2.fr Recent findings Field implementation of current recommendations, impact of prophylactic regimens on Current Opinion in HIV and AIDS 2008, 3:161– subsequent antiretroviral therapy response and possible new indications of antiretroviral therapy in pregnant women will be reviewed in this paper. Summary Prophylactic antiretroviral prevention of mother-to-child transmission regimens reached only 10% of the HIV-infected pregnant women in 2006, who were usually offered single-
Current Opinion in HIV and Aids – Wolters Kluwer Health
Published: Mar 1, 2008
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