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Prolactin Receptor Expression is an Independent Favorable Prognostic Marker in Human Breast Cancer

Prolactin Receptor Expression is an Independent Favorable Prognostic Marker in Human Breast Cancer RESEARCH ARTICLE Prolactin Receptor Expression is an Independent Favorable Prognostic Marker in Human Breast Cancer Ibrahim Y. Hachim, MD, MSc,* Mahmood Y. Hachim, MD, MSc,w Vanessa M. Lopez, MD,* Jean-Jacques Lebrun, PhD,z and Suhad Ali, PhD* Key Words: breast cancer, prolactin receptor, prognosis, differ- Abstract: Prolactin (PRL) hormone plays an important role in entiation the development of the mammary gland and terminal differ- (Appl Immunohistochem Mol Morphol 2015;00:000–000) entiation of the mammary epithelial cells. While initial studies suggested that PRL may contribute to the development of breast cancer through PRL/prolactin receptor (PRLR) autocrine function, mounting evidence indicate a different role for PRL, reast cancer is a heterogenous disease in its molecular, highlighting this hormone as a regulator of epithelial plasticity Bpathologic, and therapeutic features. Variations in and as a potential tumor suppressor. To gain further insights behavior and differences in response to therapy and clinical into the role of PRL in human breast carcinogenesis, im- outcome still are seen in patients with similar clinical and 2,3 munohistochemistry analyses of PRLR protein expression levels pathologic characteristics. Further classification of breast using tissue microarray of 102 cases were done in comparison cancer according to different molecular subtypes including, with various clinical/pathologic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Prolactin Receptor Expression is an Independent Favorable Prognostic Marker in Human Breast Cancer

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Aug 1, 2015

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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000178
pmid
26317306
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Prolactin Receptor Expression is an Independent Favorable Prognostic Marker in Human Breast Cancer Ibrahim Y. Hachim, MD, MSc,* Mahmood Y. Hachim, MD, MSc,w Vanessa M. Lopez, MD,* Jean-Jacques Lebrun, PhD,z and Suhad Ali, PhD* Key Words: breast cancer, prolactin receptor, prognosis, differ- Abstract: Prolactin (PRL) hormone plays an important role in entiation the development of the mammary gland and terminal differ- (Appl Immunohistochem Mol Morphol 2015;00:000–000) entiation of the mammary epithelial cells. While initial studies suggested that PRL may contribute to the development of breast cancer through PRL/prolactin receptor (PRLR) autocrine function, mounting evidence indicate a different role for PRL, reast cancer is a heterogenous disease in its molecular, highlighting this hormone as a regulator of epithelial plasticity Bpathologic, and therapeutic features. Variations in and as a potential tumor suppressor. To gain further insights behavior and differences in response to therapy and clinical into the role of PRL in human breast carcinogenesis, im- outcome still are seen in patients with similar clinical and 2,3 munohistochemistry analyses of PRLR protein expression levels pathologic characteristics. Further classification of breast using tissue microarray of 102 cases were done in comparison cancer according to different molecular subtypes including, with various clinical/pathologic

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Aug 1, 2015

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