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References (81)
-
M. Ansari, Alan Salama, Alan Salama, Tanuja Chitnis, Tanuja Chitnis, R. Smith, H. Yagita, H. Akiba, Tomohide Yamazaki, M. Azuma, H. Iwai, S. Khoury, H. Auchincloss, M. Sayegh, M. Sayegh (2003)
The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) MiceThe Journal of Experimental Medicine, 198
-
H. Tamura, K. Ogata, Haidong Dong, Lieping Chen (2003)
Immunology of B7-H1 and Its Roles in Human DiseasesInternational Journal of Hematology, 78
-
I. Guleria, A. Khosroshahi, M. Ansari, A. Habicht, M. Azuma, H. Yagita, R. Noelle, A. Coyle, A. Mellor, S. Khoury, M. Sayegh (2005)
A critical role for the programmed death ligand 1 in fetomaternal toleranceThe Journal of Experimental Medicine, 202
-
D. Pardoll (2002)
Vaccines: Spinning molecular immunology into successful immunotherapyNature Reviews Immunology, 2
-
L. Stanciu, C. Bellettato, V. Laza-Stanca, A. Coyle, A. Papi, S. Johnston (2006)
Expression of programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and inducible costimulator ligand on human respiratory tract epithelial cells and regulation by respiratory syncytial virus and type 1 and 2 cytokines.The Journal of infectious diseases, 193 3
-
P. Dunbar, Caroline Smith, D. Chao, M. Salio, D. Shepherd, F. Mirza, M. Lipp, A. Lanzavecchia, F. Sallusto, A. Evans, R. Russell‐Jones, A. Harris, V. Cerundolo (2000)
A Shift in the Phenotype of Melan-A-Specific CTL Identifies Melanoma Patients with an Active Tumor-Specific Immune Response1The Journal of Immunology, 165
-
G. Freeman, A. Long, Yoshiko Iwai, K. Bourque, T. Chernova, H. Nishimura, L. Fitz, Nelly Malenkovich, Taku Okazaki, M. Byrne, H. Horton, L. Fouser, L. Carter, V. Ling, M. Bowman, B. Carreno, M. Collins, C. Wood, T. Honjo (2000)
Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte ActivationThe Journal of Experimental Medicine, 192
-
C. Petrovas, J. Casazza, J. Brenchley, D. Price, E. Gostick, W. Adams, M. Precopio, T. Schacker, M. Roederer, D. Douek, R. Koup (2006)
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infectionThe Journal of Experimental Medicine, 203
-
Y. Agata, A. Kawasaki, H. Nishimura, Y. Ishida, T. Tsubata, H. Yagita, T. Honjo (1996)
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.International immunology, 8 5
-
This study addresses the role of PD-1 in apoptosis in HIV infection -
Taku Okazaki, A. Maeda, Hiroyuki Nishimura, T. Kurosaki, Tasuku Honjo (2001)
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosineProceedings of the National Academy of Sciences of the United States of America, 98
-
Yoshiko Iwai, S. Terawaki, M. Ikegawa, Taku Okazaki, T. Honjo (2003)
PD-1 Inhibits Antiviral Immunity at the Effector Phase in the LiverThe Journal of Experimental Medicine, 198
-
C. Blank, I. Brown, A. Peterson, M. Spiotto, Yoshiko Iwai, T. Honjo, T. Gajewski (2004)
PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T CellsCancer Research, 64
-
Daniel Barber, E. Wherry, D. Masopust, Baogong Zhu, James Allison, Arlene Sharpe, Gordon Freeman, R. Ahmed (2006)
Restoring function in exhausted CD8 T cells during chronic viral infectionNature, 439
-
K. Sheppard, L. Fitz, Julie Lee, Christina Benander, Judith George, J. Wooters, Y. Qiu, J. Jussif, L. Carter, C. Wood, D. Chaudhary (2004)
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta.FEBS letters, 574 1-3
-
S. Rosenberg (2001)
Progress in human tumour immunology and immunotherapyNature, 411
-
S. Yoshinaga, J. Whoriskey, S. Khare, U. Sarmiento, Jane Guo, T. Horan, G. Shih, Ming Zhang, M. Coccia, T. Kohno, Anna Tafuri-Bladt, D. Brankow, P. Campbell, D. Chang, L. Chiu, Tianang Dai, G. Duncan, G. Elliott, A. Hui, Susan McCabe, S. Scully, A. Shahinian, Christine Shaklee, G. Van, T. Mak, G. Senaldi (1999)
T-cell co-stimulation through B7RP-1 and ICOSNature, 402
-
B. Zhu, I. Guleria, A. Khosroshahi, T. Chitnis, J. Imitola, M. Azuma, H. Yagita, M. Sayegh, S. Khoury (2006)
Differential Role of Programmed Death-Ligand 1 and Programmed Death-Ligand 2 in Regulating the Susceptibility and Chronic Progression of Experimental Autoimmune Encephalomyelitis1The Journal of Immunology, 176
-
Shengdian Wang, J. Bajorath, D. Flies, Haidong Dong, T. Honjo, Lieping Chen (2003)
Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 InteractionThe Journal of Experimental Medicine, 197
-
H. Geng, Gui-mei Zhang, Han Xiao, Ye Yuan, Dong Li, Hui-fen Zhang, Huiyuan Qiu, Yu-fei He, Zuo-hua Feng (2006)
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD‐1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanomaInternational Journal of Cancer, 118
-
Hiroyuki Nishimura, M. Nose, H. Hiai, N. Minato, T. Honjo (1999)
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.Immunity, 11 2
-
J. Riley, C. June (2004)
The CD 28 Family : a T Cell Rheostat for Therapeutic Control of T Cell Activation -
Xingluo Liu, J. Gao, J. Wen, Lijie Yin, O. Li, T. Zuo, T. Gajewski, yang-xin fu, P. Zheng, Yang Liu (2003)
B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent MechanismThe Journal of Experimental Medicine, 197
-
M. Keir, Spencer Liang, I. Guleria, Y. Latchman, A. Qipo, L. Albacker, M. Koulmanda, G. Freeman, M. Sayegh, A. Sharpe (2006)
Tissue expression of PD-L1 mediates peripheral T cell toleranceThe Journal of Experimental Medicine, 203
-
Y. Latchman, Spencer Liang, Yin-Xia Wu, T. Chernova, R. Sobel, M. Klemm, V. Kuchroo, G. Freeman, A. Sharpe (2004)
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells.Proceedings of the National Academy of Sciences of the United States of America, 101 29
-
J. Riley, C. June (2005)
The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.Blood, 105 1
-
F. Hirano, K. Kaneko, H. Tamura, Haidong Dong, Shengdian Wang, Masao Ichikawa, C. Rietz, D. Flies, J. Lau, G. Zhu, K. Tamada, Lieping Chen (2005)
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.Cancer research, 65 3
-
A. Zajac, J. Blattman, K. Murali-Krishna, D. Sourdive, M. Suresh, J. Altman, R. Ahmed (1998)
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector FunctionThe Journal of Experimental Medicine, 188
-
B. Fife, I. Guleria, M. Bupp, T. Eagar, Q. Tang, Hélène Bour-Jordan, H. Yagita, M. Azuma, M. Sayegh, J. Bluestone (2006)
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathwayThe Journal of Experimental Medicine, 203
-
Fumihiko Tsushima, Kae Tanaka, N. Otsuki, Pornpan Youngnak, H. Iwai, K. Omura, M. Azuma (2006)
Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma.Oral oncology, 42 3
-
Jian Wang, Taku Yoshida, Fumio Nakaki, H. Hiai, Taku Okazaki, T. Honjo (2005)
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.Proceedings of the National Academy of Sciences of the United States of America, 102 33
-
S. Khoury, M. Sayegh (2004)
The roles of the new negative T cell costimulatory pathways in regulating autoimmunity.Immunity, 20 5
-
T. Shin, K. Yoshimura, Takako Shin, E. Crafton, H. Tsuchiya, F. Housseau, H. Koseki, R. Schulick, Lieping Chen, D. Pardoll (2005)
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responsesThe Journal of Experimental Medicine, 201
-
J. Hori, Mingcong Wang, M. Miyashita, K. Tanemoto, Hiroshi Takahashi, T. Takemori, K. Okumura, H. Yagita, M. Azuma (2006)
B7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts1The Journal of Immunology, 177
-
A. Sharpe, A. Abbas (2006)
T-cell costimulation--biology, therapeutic potential, and challenges.The New England journal of medicine, 355 10
-
E. Wherry, D. Barber, S. Kaech, S. Kaech, J. Blattman, J. Blattman, R. Ahmed (2004)
Antigen-independent memory CD8 T cells do not develop during chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America, 101 45
-
C. Blank, I. Brown, A. Peterson, M. Spiotto, Yoshiko Iwai, T. Honjo, T. Gajewski (2004)
PD-L 1 / B 7 H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor ( TCR ) Transgenic CD 8 T Cells -
This paper demonstrates the role of PD-1 in the exhaustion of antigen-specific CD8 and CD4 T cells in HIV infection and the proliferation increase by blocking the PD-1/PD-L1 pathway -
(2006)
Liver infiltrating lymphocytes in chronic human HCV infection display an exhausted phenotype with high PD - 1 and low CD 127 expression -
This study describes an antigen-specific therapy to treat diabetes in non-obese mice after disease onset driven by the PD-1/PD-L1 pathway -
Yongliang Zhang, Yeonseok Chung, C. Bishop, B. Daugherty, H. Chute, P. Holst, C. Kurahara, F. Lott, N. Sun, A. Welcher, C. Dong (2006)
Regulation of T cell activation and tolerance by PDL 2 -
R. Thompson, Michael Gillett, J. Cheville, C. Lohse, Haidong Dong, W. Webster, K. Krejci, J. Lobo, S. Sengupta, Lieping Chen, H. Zincke, M. Blute, S. Strome, B. Leibovich, E. Kwon (2004)
Costimulatory B 7-H 1 in renal cell carcinoma patients : Indicator of tumor aggressiveness and potential therapeutic target -
Her Jun, S. Seo, Hye‐Young Jeong, Hyoun-Mi Seo, G. Zhu, Lieping Chen, I. Choi (2005)
B7‐H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK)FEBS Letters, 579
-
M. Río, G. Peñuelas-Rivas, R. Domínguez‐Perles, P. Ramírez, P. Parrilla, J. Rodriguez-Barbosa (2005)
Antibody‐mediated signaling through PD‐1 costimulates T cells and enhances CD28‐dependent proliferationEuropean Journal of Immunology, 35
-
Yongliang Zhang, Yeonseok Chung, C. Bishop, B. Daugherty, H. Chute, P. Holst, C. Kurahara, F. Lott, N. Sun, A. Welcher, C. Dong (2006)
Regulation of T cell activation and tolerance by PDL2.Proceedings of the National Academy of Sciences of the United States of America, 103 31
-
Marcus Mühlbauer, M. Fleck, C. Schütz, T. Weiss, M. Froh, C. Blank, J. Schölmerich, C. Hellerbrand (2006)
PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosisZeitschrift Fur Gastroenterologie, 44
-
Haidong Dong, G. Zhu, K. Tamada, Lieping Chen (1999)
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretionNature Medicine, 5
-
P. Romero, P. Dunbar, D. Valmori, M. Pittet, G. Ogg, D. Rimoldi, Ji-Li Chen, D. Liénard, J. Cerottini, V. Cerundolo (1998)
Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T LymphocytesThe Journal of Experimental Medicine, 188
-
Natalia Martín‐Orozco, Yi-hong Wang, H. Yagita, C. Dong (2006)
Cutting Edge: Programed Death (PD) Ligand-1/PD-1 Interaction Is Required for CD8+ T Cell Tolerance to Tissue Antigens1The Journal of Immunology, 177
-
J. Chemnitz, R. Parry, K. Nichols, C. June, J. Riley (2004)
SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation1The Journal of Immunology, 173
-
R. Greenwald, G. Freeman, A. Sharpe (2005)
The B7 family revisited.Annual review of immunology, 23
-
P. Bretscher (1999)
A two-step, two-signal model for the primary activation of precursor helper T cells.Proceedings of the National Academy of Sciences of the United States of America, 96 1
-
Pornpan Youngnak, Y. Kozono, H. Kozono, H. Iwai, N. Otsuki, Hisayo Jin, K. Omura, H. Yagita, D. Pardoll, Lieping Chen, M. Azuma (2003)
Differential binding properties of B7-H1 and B7-DC to programmed death-1.Biochemical and biophysical research communications, 307 3
-
M. Smyth, D. Godfrey, J. Trapani (2001)
A fresh look at tumor immunosurveillance and immunotherapyNature Immunology, 2
-
T. Curiel, Shuang Wei, Haidong Dong, Xavier Alvarez, P. Cheng, P. Mottram, R. Krzysiek, K. Knutson, B. Daniel, M. Zimmermann, O. David, M. Burow, Alan Gordon, N. Dhurandhar, L. Myers, R. Berggren, A. Hemminki, R. Alvarez, D. Émilie, D. Curiel, Lieping Chen, W. Zou (2003)
Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunityNature Medicine, 9
-
S. Kirchberger, O. Majdic, P. Steinberger, S. Blüml, K. Pfistershammer, G. Zlabinger, L. Deszcz, E. Kuechler, W. Knapp, J. Stöckl (2005)
Human Rhinoviruses Inhibit the Accessory Function of Dendritic Cells by Inducing Sialoadhesin and B7-H1 Expression1The Journal of Immunology, 175
-
S. Urbani, B. Amadei, D. Tola, M. Massari, S. Schivazappa, G. Missale, C. Ferrari (2006)
PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 ExhaustionJournal of Virology, 80
-
Yuichiro Ohigashi, M. Sho, Yukishige Yamada, Y. Tsurui, K. Hamada, N. Ikeda, T. Mizuno, R. Yoriki, H. Kashizuka, K. Yane, Fumihiko Tsushima, N. Otsuki, H. Yagita, M. Azuma, Y. Nakajima (2005)
Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal CancerClinical Cancer Research, 11
-
Peter Lee, C. Yee, P. Savage, L. Fong, D. Brockstedt, J. Weber, Denise Johnson, S. Swetter, John Thompson, P. Greenberg, M. Roederer, Mark Davis (1999)
Characterization of circulating T cells specific for tumor-associated antigens in melanoma patientsNature Medicine, 5
-
P. Connell, D. Christie, W. May (1976)
Volunteers at risk.Journal of medical ethics, 2 2
-
S. Dzik (2000)
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin 10 secretionTransfusion Medicine Reviews, 14
-
L. Trautmann, L. Janbazian, N. Chomont, E. Said, S. Gimmig, B. Bessette, M. Boulassel, E. Delwart, H. Sepulveda, R. Balderas, J. Routy, E. Haddad, R. Sékaly (2006)
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionNature Medicine, 12
-
K. Sheppard, L. Fitz, Julie Lee, Christina Benander, Judith George, J. Wooters, Y. Qiu, J. Jussif, Laura Carter, C. Wood, D. Chaudhary (2004)
PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθFEBS Letters, 574
-
D. Trabattoni, M. Saresella, M. Biasin, A. Boasso, L. Piacentini, P. Ferrante, Haidong Dong, R. Maserati, G. Shearer, Lieping Chen, M. Clerici (2003)
B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression.Blood, 101 7
-
L. Geng, G. Jiang, Y. Fang, S. Dong, H. Xie, Y. Chen, M. Shen, S. Zheng (2006)
B7‐H1 expression is upregulated in peripheral blood CD14+ monocytes of patients with chronic hepatitis B virus infection, which correlates with higher serum IL‐10 levelsJournal of Viral Hepatitis, 13
-
R. Parry, J. Chemnitz, K. Frauwirth, A. Lanfranco, Inbal Braunstein, Sumire Kobayashi, P. Linsley, C. Thompson, J. Riley (2004)
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct MechanismsMolecular and Cellular Biology, 25
-
Y. Ishida, Y. Agata, Keiichi Shibahara, T. Honjo (1992)
Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.The EMBO Journal, 11
-
C. Day, D. Kaufmann, P. Kiepiela, Julia Brown, Eshia Moodley, S. Reddy, Elizabeth Mackey, Joseph Miller, A. Leslie, Chantal DePierres, Z. Mncube, Jaikumar Duraiswamy, Baogong Zhu, Q. Eichbaum, M. Altfeld, E. Wherry, H. Coovadia, P. Goulder, P. Goulder, P. Goulder, P. Klenerman, R. Ahmed, G. Freeman, B. Walker, B. Walker, B. Walker (2006)
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionNature, 443
-
C. Blank, J. Kuball, Simon Voelkl, H. Wiendl, B. Becker, B. Walter, O. Majdic, T. Gajewski, M. Theobald, R. Andreesen, A. Mackensen (2006)
Blockade of PD‐L1 (B7‐H1) augments human tumor‐specific T cell responses in vitroInternational Journal of Cancer, 119
-
岩井 佳子 (2002)
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation -
H. Khong, N. Restifo (2002)
Natural selection of tumor variants in the generation of “tumor escape” phenotypesNature Immunology, 3
-
G. Cai, A. Karni, E. Oliveira, H. Weiner, D. Hafler, G. Freeman (2004)
PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells.Cellular immunology, 230 2
-
G. Suntharalingam, M. Perry, S. Ward, S. Brett, A. Castello-Cortes, Michael Brunner, N. Panoskaltsis (2006)
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412.The New England journal of medicine, 355 10
-
S. Strome, Haidong Dong, H. Tamura, Stephen Voss, D. Flies, K. Tamada, D. Salomão, J. Cheville, F. Hirano, Wei Lin, J. Kasperbauer, K. Ballman, Lieping Chen (2003)
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.Cancer research, 63 19
-
S. Tseng, M. Otsuji, K. Gorski, Xin Huang, J. Slansky, S. Pai, A. Shalabi, T. Shin, D. Pardoll, H. Tsuchiya (2001)
B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T CellsThe Journal of Experimental Medicine, 193
-
H. Nishimura, N. Minato, T. Nakano, T. Honjo (1998)
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses.International immunology, 10 10
-
L. Marengère, P. Waterhouse, G. Duncan, H. Mittrücker, G. Feng, T. Mak (1996)
Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4Science, 272
-
R. Nurieva, Sunil Thomas, Thang Nguyen, Natalia Martín‐Orozco, Ying Wang, M. Kaja, Xue-Zhong Yu, C. Dong (2006)
T‐cell tolerance or function is determined by combinatorial costimulatory signalsThe EMBO Journal, 25
-
Y. Latchman, C. Wood, T. Chernova, D. Chaudhary, M. Borde, I. Chernova, Yoshiko Iwai, A. Long, Julia Brown, Raquel Nunes, E. Greenfield, K. Bourque, V. Boussiotis, Laura Carter, B. Carreno, Nelly Malenkovich, H. Nishimura, Taku Okazaki, T. Honjo, A. Sharpe, G. Freeman (2001)
PD-L2 is a second ligand for PD-1 and inhibits T cell activationNature Immunology, 2
-
T. Shin, G. Kennedy, K. Gorski, H. Tsuchiya, H. Koseki, M. Azuma, H. Yagita, Lieping Chen, J. Powell, D. Pardoll, F. Housseau (2003)
Cooperative B7-1/2 (CD80/CD86) and B7-DC Costimulation of CD4+ T Cells Independent of the PD-1 ReceptorThe Journal of Experimental Medicine, 198
-
D. Leach, M. Krummel, J. Allison (1996)
Enhancement of Antitumor Immunity by CTLA-4 BlockadeScience, 271
- ISSN
- 1746-630X
- eISSN
- 1746-6318
- DOI
- 10.1097/COH.0b013e3280ebb5c9
- pmid
- 19372890
- Publisher site
- See Article on Publisher Site
Abstract
Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections a,b,c a,b,c a,b,c a,d Lydie Trautmann , Elias A. Said , Rabih Halwani , Loury Janbazian , a,b,c a,b,c a,b,c Nicolas Chomont , Mohamed El-Far , Gae ¨ lle Breton , a,b,c,d a,b,c,d Elias K. Haddad and Rafick-Pierre Sekaly Purpose of review Abbreviations The intricate balance between positive and negative signals APC antigen-presenting cells delivered by accessory molecules is crucial to generate HCV hepatitis C virus HSV herpes simplex virus efficient immune responses while maintaining tolerance and ITSM immunoreceptor tyrosine-based switch motif preventing autoimmunity. Of these molecules, programmed LCMV lymphocytic choriomeningitis virus SHP Src homology region 2 domain-containing phosphatase death 1 has been described as a negative regulator of T-cell TCR T-cell receptor activation. This review will focus on current knowledge about PD-1 regulation in different diseases and discuss its potential 2007 Lippincott Williams & Wilkins benefits for the development of novel immune therapies. 1746-630X Recent findings PD-1 has recently been shown to be upregulated on HIV- specific CD8 T cells, whereas the PD-1 expression level Introduction was significantly correlated with viral load. Blockade of the The ‘two-signal’ model governs
Journal
Current Opinion in HIV and Aids – Wolters Kluwer Health
Published: May 1, 2007