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- Copyright
- Copyright © 2014 by the International Association for the Study of Lung Cancer
- ISSN
- 1556-0864
- DOI
- 10.1097/JTO.0000000000000243
- pmid
- 25036876
- Publisher site
- See Article on Publisher Site
Abstract
Original Atricle Prognostic Impact of Bcl-2 Depends on Tumor Histology and Expression of MALAT-1 lncRNA in Non–Small-Cell Lung Cancer Lars Henning Schmidt,* Dennis Görlich,† Tilmann Spieker,‡ Christian Rohde,* Martin Schuler,§‖ Michael Mohr,* Julia Humberg,* Tim Sauer,* Nils H. Thoenissen,* Andreas Huge,¶ Reinhard Voss,¶ Alessandro Marra,# Andreas Faldum,† Carsten Müller-Tidow,* Wolfgang E. Berdel,* and Rainer Wiewrodt* Key Words: NSCLC, Apoptosis, MALAT-1, Overall survival Introduction: Apoptosis is a crucial pathway in tumor growth and metastatic development. Apoptotic proteins regulate the underlying (J Thorac Oncol. 2014;9: 1294–1304) molecular cascades and are thought to modulate the tumor response to chemotherapy and radiation. However, the prognostic value of the expression of apoptosis regulators in localized non–small-cell lung ung cancer is still one of the most lethal and most prevalent cancer (NSCLC) is still unclear. Lcancers in the world. To improve therapy and decrease its Methods: We investigated the protein expression of apoptosis regu- high lethality, new molecular markers and targeted therapies lators Bcl-2, Bcl-xl, Mcl-1, and pp32/PHAPI, and the expression of are required. the lncRNA MALAT-1 in tumor samples from 383 NSCLC patients Cancerogenesis and chemotherapy resistance are both (median age: 65.6 years; 77.5% male; paraffin-embedded tissue driven by deregulation of apoptosis (also referred to as the microarrays). For statistical analysis correlation tests, Log rank tests “programmed cell death”).
Journal
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Sep 1, 2014