Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
ORIGINAL ARTICLE Profiling of Oncogenic Driver Events in Lung Adenocarcinoma Revealed MET Mutation as Independent Prognostic Factor Sai F. Yeung, BSc,*†‡ Joanna H.M. Tong, PhD,*†‡ Peggy P.W. Law, MPhil,*†‡ Lau Y. Chung, AD,*†‡ Raymond W.M. Lung, PhD,*†‡ Carol Y.K. Tong, MPhil,*†‡ Chit Chow, PhD,*†‡ Anthony W.H. Chan, FRCPA,*†‡ Innes Y.P. Wan, FRCS,§ Tony S.K. Mok, MD,‡¶ and Ka F. To, FRCPA*†‡ Conclusion: Actionable driver events can be detected in two thirds Introduction: Oncogenic driver mutations activating receptor tyro- of lung adenocarcinoma. MET DNA alterations define a subset sine kinase pathways are promising predictive markers for targeted of patients with aggressive diseases that might potentially benefit treatment. We investigated the mutation profile of an updated driver from anti-MET targeted therapy. High negative predictive values of events list on receptor tyrosine kinase/RAS/PI3K axis and the clini- thyroid transcription factor-1 and MET expression suggest poten- copathologic implications in a cohort of never-smoker predominated tial roles as surrogate markers for EGFR and/or MET mutations. Chinese lung adenocarcinoma. Key Words: Lung cancer, EGFR, KRAS, ALK, HER2, BRAF, MET, Methods: We tested 154 lung adenocarcinomas and adenosquamous ROS1, RIT1, TTF-1 lung adenocarcinoma, NRAS, Driver mutations, carcinomas for EGFR, KRAS, HER2, BRAF, PIK3CA, MET, NRAS, Oncogenic driver mutation, East Asian lung cancer, MET amplifica- MAP2K1, and RIT1
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Sep 1, 2015
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.