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M. Böttcher, T. Abrahamsson, M. Fredriksson, Ted Jakobsson, B. Björkstén (2008)
Low breast milk TGF‐β2 is induced by Lactobacillus reuteri supplementation and associates with reduced risk of sensitization during infancyPediatric Allergy and Immunology, 19
M. Kuitunen, K. Kukkonen, K. Juntunen‐Backman, R. Korpela, T. Poussa, T. Tuure, T. Haahtela, E. Savilahti (2009)
Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort.The Journal of allergy and clinical immunology, 123 2
S. Arslanoğlu, G. Moro, Joachim Schmitt, Laura Tandoi, Silvia Rizzardi, G. Boehm (2008)
Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life.The Journal of nutrition, 138 6
P. Sansonetti, R. Medzhitov (2009)
Learning Tolerance while Fighting IgnoranceCell, 138
M. Kalliomäki, P. Kirjavainen, E. Eerola, P. Kero, S. Salminen, E. Isolauri (2001)
Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing.The Journal of allergy and clinical immunology, 107 1
E. Marschan, M. Kuitunen, K. Kukkonen, T. Poussa, A. Sarnesto, T. Haahtela, R. Korpela, E. Savilahti, O. Vaarala (2008)
Probiotics in infancy induce protective immune profiles that are characteristic for chronic low‐grade inflammationClinical & Experimental Allergy, 38
M. Kuitunen, A. Kukkonen, E. Savilahti (2012)
Impact of Maternal Allergy and Use of Probiotics during Pregnancy on Breast Milk Cytokines and Food Antibodies and Development of Allergy in Children until 5 YearsInternational Archives of Allergy and Immunology, 159
M. Kalliomäki, S. Salminen, T. Poussa, H. Arvilommi, E. Isolauri (2003)
Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trialThe Lancet, 361
K. Kukkonen, E. Savilahti, T. Haahtela, K. Juntunen‐Backman, R. Korpela, T. Poussa, T. Tuure, M. Kuitunen (2008)
Long-Term Safety and Impact on Infection Rates of Postnatal Probiotic and Prebiotic (Synbiotic) Treatment: Randomized, Double-Blind, Placebo-Controlled TrialPediatrics, 122
C. Hammerman, A. Bin-Nun, M. Kaplan (2006)
Safety of probiotics: comparison of two popular strainsBMJ : British Medical Journal, 333
N. Sudo, S. Sawamura, Kazuo Tanaka, Y. Aiba, C. Kubo, Y. Koga (1997)
The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction.Journal of immunology, 159 4
S. Lahtinen, R. Boyle, S. Kivivuori, F. Oppedisano, Katherine Smith, R. Robins-Browne, S. Salminen, M. Tang (2009)
Prenatal probiotic administration can influence Bifidobacterium microbiota development in infants at high risk of allergy.The Journal of allergy and clinical immunology, 123 2
L. Kobyletzki, C. Bornehag, M. Hasselgren, M. Larsson, Cecilia Lindström, Å. Svensson (2012)
Eczema in early childhood is strongly associated with the development of asthma and rhinitis in a prospective cohortBMC Dermatology, 12
B. Björkstén, E. Sepp, K. Julge, T. Voor, M. Mikelsaar (2001)
Allergy development and the intestinal microflora during the first year of life.The Journal of allergy and clinical immunology, 108 4
M. Saxelin, A. Lassig, H. Karjalainen, S. Tynkkynen, Anu Surakka, H. Vapaatalo, S. Järvenpää, R. Korpela, M. Mutanen, K. Hatakka (2010)
Persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese.International journal of food microbiology, 144 2
D. Osborn, J. Sinn (2007)
Prebiotics in infants for prevention of allergic disease and food hypersensitivity.The Cochrane database of systematic reviews, 4
Ji Kim, Jung Kwon, S. Ahn, Sang Lee, Youngshin Han, Young Choi, Soo-young Lee, K. Ahn, G. Ji (2010)
Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double‐blind, randomized, placebo‐controlled trialPediatric Allergy and Immunology, 21
G. Wlasiuk, D. Vercelli (2012)
The farm effect, or: when, what and how a farming environment protects from asthma and allergic diseaseCurrent Opinion in Allergy and Clinical Immunology, 12
Anu Huurre, K. Laitinen, S. Rautava, M. Korkeamäki, E. Isolauri (2008)
Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double‐blind placebo‐controlled studyClinical & Experimental Allergy, 38
S. Sicherer, L. Ford (2009)
Probiotic Supplementation in the First 6 Months of Life in at Risk Asian Infants: Effects on Eczema and Atopic Sensitization at the Age of 1 YearPediatrics, 124
S. Prescott, J. Wiltschut, A. Taylor, L. Westcott, W. Jung, Helen Currie, J. Dunstan (2008)
Early markers of allergic disease in a primary prevention study using probiotics: 2.5‐year follow‐up phaseAllergy, 63
Mei Wang, Caroline Karlsson, C. Olsson, I. Adlerberth, A. Wold, D. Strachan, Paolo Martricardi, N. Åberg, M. Perkin, S. Tripodi, A. Coates, B. Hesselmar, R. Saalman, G. Molin, S. Ahrné (2008)
Reduced diversity in the early fecal microbiota of infants with atopic eczema.The Journal of allergy and clinical immunology, 121 1
I. Schabussova, U. Wiedermann (2008)
Lactic acid bacteria as novel adjuvant systems for prevention and treatment of atopic diseasesCurrent Opinion in Allergy and Clinical Immunology, 8
The second largest RCT unique in comparing two different probiotics with placebo and showing an eczema-preventive effect from one of them (lactobacillus) until 4 years, and that by preventing eczema
P. Brandtzaeg (2010)
The mucosal immune system and its integration with the mammary glands.The Journal of pediatrics, 156 2 Suppl
D. Snydman (2008)
The safety of probiotics.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 46 Suppl 2
Gerrard Jw, Geddes Ca, Reggin Pl, Gerrard Cd, S. Horne (1976)
Serum IgE levels in white and metis communities in Saskatchewan.Annals of allergy, 37 2
G. Moro, S. Arslanoğlu, B. Stahl, J. Jelinek, U. Wahn, G. Boehm (2006)
A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of ageArchives of Disease in Childhood, 91
L. Niers, R. Martin, G. Rijkers, F. Sengers, H. Timmerman, N. Uden, H. Smidt, J. Kimpen, M. Hoekstra (2009)
The effects of selected probiotic strains on the development of eczema (the PandA study)Allergy, 64
B. Björkstén (2006)
The gut microbiota: a complex ecosystemClinical & Experimental Allergy, 36
I. Ismail, F. Oppedisano, Shayne Joseph, R. Boyle, R. Robins-Browne, M. Tang (2012)
Prenatal administration of Lactobacillus rhamnosus has no effect on the diversity of the early infant gut microbiotaPediatric Allergy and Immunology, 23
S. Prescott, K. Wickens, L. Westcott, W. Jung, Helen Currie, P. Black, T. Stanley, E. Mitchell, P. Fitzharris, R. Siebers, L. Wu, Julian Crane (2008)
Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon‐γ and breast milk transforming growth factor‐β and immunoglobin A detectionClinical & Experimental Allergy, 38
C. Grüber, M. Stuijvenberg, F. Mosca, G. Moro, G. Chirico, C. Braegger, J. Riedler, G. Boehm, U. Wahn (2010)
Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants.The Journal of allergy and clinical immunology, 126 4
C. Ou, Ho-Chang Kuo, Lin Wang, T. Hsu, H. Chuang, Chieh-An Liu, Jen-Chieh Chang, Jen-Chieh Chang, Hong-Ren Yu, Kuender Yang (2012)
Prenatal and postnatal probiotics reduces maternal but not childhood allergic diseases: a randomized, double‐blind, placebo‐controlled trialClinical & Experimental Allergy, 42
I. Adlerberth, Fehmida Jalil, Barbro Carlsson, L. Mellander, Lars Hanson, Peter Larsson, K. Khalil, Agnes Wold (1998)
High turnover rate of Escherichia coli strains in the intestinal flora of infants in PakistanEpidemiology and Infection, 121
Y. Lee, S. Mazmanian (2010)
Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?Science, 330
C. West, M. Hammarström, O. Hernell (2009)
Probiotics during weaning reduce the incidence of eczemaPediatric Allergy and Immunology, 20
T. Abrahamsson, Ted Jakobsson, M. Böttcher, M. Fredrikson, M. Jenmalm, B. Björkstén, G. Oldaéus (2007)
Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial.The Journal of allergy and clinical immunology, 119 5
A. Taylor, J. Dunstan, S. Prescott (2007)
Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial.The Journal of allergy and clinical immunology, 119 1
M. Kalliomäki, S. Salminen, H. Arvilommi, P. Kero, P. Koskinen, E. Isolauri (2001)
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trialThe Lancet, 357
C. Dotterud, Ola Storrø, R. Johnsen, Torbjørn Øien (2010)
Probiotics in pregnant women to prevent allergic disease: a randomized, double‐blind trialBritish Journal of Dermatology, 163
Öner Özdemir (2010)
Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical dataClinical & Experimental Immunology, 160
T. Abrahamsson, Hedvig Jakobsson, Anders Andersson, Bengt Björkstén, Lars Engstrand, M. Jenmalm (2012)
Low diversity of the gut microbiota in infants with atopic eczema.The Journal of allergy and clinical immunology, 129 2
M. Kuitunen, E. Savilahti, A. Sarnesto (1994)
Human alpha-lactalbumin and bovine beta-lactoglobulin absorption in infants.Allergy, 49 5
A large randomized controlled trial (RCT) from Australia using postanatal-only probiotic supplementation showing no effect on eczema prevention in 5-year follow-up
M. Kuitunen, E. Savilahti, A. Sarnesto (1994)
Human α‐lactalbumin and bovine β‐lactoglobulin absorption in infantsAllergy, 49
M. Tang, S. Lahtinen, R. Boyle (2010)
Probiotics and prebiotics: clinical effects in allergic diseaseCurrent Opinion in Pediatrics, 22
M. Kopp, Isabell Hennemuth, A. Heinzmann, R. Urbanek (2008)
Randomized, Double-Blind, Placebo-Controlled Trial of Probiotics for Primary Prevention: No Clinical Effects of Lactobacillus GG SupplementationPediatrics, 121
S. Rautava, M. Kalliomäki, E. Isolauri (2002)
Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant.The Journal of allergy and clinical immunology, 109 1
K. Wickens, Peter Black, Thorsten Stanley, Edwin Mitchell, C. Barthow, P. Fitzharris, Gordon Purdie, Julian Crane (2012)
A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 yearsClinical & Experimental Allergy, 42
M. Foisy, R. Boyle, J. Chalmers, E. Simpson, H. Williams (2011)
Overview of Reviews The prevention of eczema in infants and children: an overview of Cochrane and non-Cochrane reviews.Evidence-based child health : a Cochrane review journal, 6 5
E. Savilahti, M. Kuitunen, O. Vaarala (2008)
Pre and probiotics in the prevention and treatment of food allergyCurrent Opinion in Allergy and Clinical Immunology, 8
M. Jensen, Suzanne Meldrum, A. Taylor, J. Dunstan, S. Prescott (2012)
Early probiotic supplementation for allergy prevention: long-term outcomes.The Journal of allergy and clinical immunology, 130 5
S. Rautava, Essi Kainonen, S. Salminen, E. Isolauri (2012)
Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant.The Journal of allergy and clinical immunology, 130 6
A. Fiocchi, W. Burks, S. Bahna, L. Bielory, R. Boyle, R. Cocco, S. Dreborg, R. Goodman, M. Kuitunen, T. Haahtela, R. Heine, G. Lack, D. Osborn, H. Sampson, G. Tannock, B. Lee (2012)
Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position PaperThe World Allergy Organization Journal, 5
M. Kalliomäki, S. Salminen, T. Poussa, E. Isolauri (2007)
Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial.The Journal of allergy and clinical immunology, 119 4
M. Ege, C. Bieli, R. Frei, R. Strien, J. Riedler, E. Ublagger, D. Schram-Bijkerk, B. Brunekreef, M. Hage, A. Scheynius, G. Pershagen, M. Benz, R. Lauener, E. Mutius, C. Braun‐Fahrländer (2006)
Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children.The Journal of allergy and clinical immunology, 117 4
K. Kukkonen, E. Savilahti, T. Haahtela, K. Juntunen‐Backman, R. Korpela, T. Poussa, T. Tuure, M. Kuitunen (2007)
Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial.The Journal of allergy and clinical immunology, 119 1
M. Morisset, C. Aubert-Jacquin, P. Soulaines, D. Moneret-vautrin, C. Dupont (2011)
A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergyEuropean Journal of Clinical Nutrition, 65
K. Wickens, P. Black, T. Stanley, E. Mitchell, P. Fitzharris, G. Tannock, G. Purdie, J. Crane (2008)
A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial.The Journal of allergy and clinical immunology, 122 4
S. Rautava, H. Arvilommi, E. Isolauri (2006)
Specific Probiotics in Enhancing Maturation of IgA Responses in Formula-Fed InfantsPediatric Research, 60
M. Ege (2011)
Intestinal microbial diversity in infancy and allergy risk at school age.The Journal of allergy and clinical immunology, 128 3
Soh (2009)
Probiotic supplementation in the first 6 months of life in at risk Asian infants: effects on eczema and atopic sensitization at the age of 1 year.Clin Exp Allergy, 39
A. Wold (1998)
The hygiene hypotheslis revised: is the rising frequency of allergy due to changes in the intestinal flora?Allergy, 53
R. Boyle, I. Ismail, S. Kivivuori, P. Licciardi, R. Robins-Browne, Li-Jeen Mah, C. Axelrad, S. Moore, S. Donath, J. Carlin, S. Lahtinen, M. Tang (2011)
Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trialAllergy, 66
REVIEW URRENT Probiotics and prebiotics in preventing food allergy PINION and eczema Mikael Kuitunen Purpose of review To describe the current literature on clinical trials of probiotics for eczema and food allergy prevention in view of recent new approaches and long-term follow-ups. Recent findings Attempting allergy prevention by probiotic administration has been most successful when assessing atopic eczema, the most prevalent allergic disease at an early age. More than half of the published studies demonstrate a decrease in eczema prevalence until 2 years, whereas the remaining studies fail to show an effect. Effects have been most consistent with combined prenatal and direct postnatal supplementation of the infant and appear strain-specific, with Lactobacillus rhamnosus most often showing an effect. Prenatal- only and postnatal-only studies often fail to show effects. Recent long-time follow-ups have shown promising but not consistent results. A very recent follow-up of a large well conducted cohort shows that long-term effects of eczema prevention persists until age 4 and prevention of respiratory allergies might also be possible. Summary Prevention of eczema with probiotics seem to work until age 2 years and extended effects until 4 years have been shown in high-risk for allergy cohorts. Effects are strain-specific, with
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Jun 1, 2013
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