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Primary Signet-ring Cell Carcinoma of the Urinary Bladder A Clinicopathologic and Immunohistochemical Study of 5 Cases

Primary Signet-ring Cell Carcinoma of the Urinary Bladder A Clinicopathologic and... RESEARCH ARTICLE Primary Signet-ring Cell Carcinoma of the Urinary Bladder A Clinicopathologic and Immunohistochemical Study of 5 Cases Rachele Del Sordo, MD, Guido Bellezza, MD, Renato Colella, MD, Maria Grazia Mameli, Lab Tech, Angelo Sidoni, MD, and Antonio Cavaliere, MD determine staging, appropriate therapy, and assess prog- Abstract: Primary signet-ring cell carcinoma of the urinary nosis. Histologically, urinary bladder adenocarcinomas, 9 10 bladder is a rare histologic variant of adenocarcinoma. colorectal and gastric neoplasms, prostatic, and female Generally, this neoplasm occurs in middle age and the clinical genital tract primaries are similar, and distinction between presentation does not differ from the most frequent transitional these can be very difficult, if not impossible, when the cell carcinomas. The prognosis is frequently poor as at diagnosis neoplasm is undifferentiated or is a signet-ring cell it is often in an advanced phase. It is essential to distinguish this carcinoma (SRCC), especially when the diagnostic biopsy carcinoma from metastases, as different therapeutic strategies material is limited and clinical information is incomplete. are often necessary. We present 5 cases of primary signet-ring We report 5 cases of primary urinary bladder SRCC cell carcinoma of the urinary bladder and we used a panel of evaluated http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Primary Signet-ring Cell Carcinoma of the Urinary Bladder A Clinicopathologic and Immunohistochemical Study of 5 Cases

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e31816a7466
pmid
18698262
Publisher site
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Abstract

RESEARCH ARTICLE Primary Signet-ring Cell Carcinoma of the Urinary Bladder A Clinicopathologic and Immunohistochemical Study of 5 Cases Rachele Del Sordo, MD, Guido Bellezza, MD, Renato Colella, MD, Maria Grazia Mameli, Lab Tech, Angelo Sidoni, MD, and Antonio Cavaliere, MD determine staging, appropriate therapy, and assess prog- Abstract: Primary signet-ring cell carcinoma of the urinary nosis. Histologically, urinary bladder adenocarcinomas, 9 10 bladder is a rare histologic variant of adenocarcinoma. colorectal and gastric neoplasms, prostatic, and female Generally, this neoplasm occurs in middle age and the clinical genital tract primaries are similar, and distinction between presentation does not differ from the most frequent transitional these can be very difficult, if not impossible, when the cell carcinomas. The prognosis is frequently poor as at diagnosis neoplasm is undifferentiated or is a signet-ring cell it is often in an advanced phase. It is essential to distinguish this carcinoma (SRCC), especially when the diagnostic biopsy carcinoma from metastases, as different therapeutic strategies material is limited and clinical information is incomplete. are often necessary. We present 5 cases of primary signet-ring We report 5 cases of primary urinary bladder SRCC cell carcinoma of the urinary bladder and we used a panel of evaluated

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2009

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