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CASE REPORT Primary Mucinous Adenocarcinoma of the Epididymis: Report of a Rare Case With Molecular Genetic Characterization Including Mutation Analysis of the TP53 Gene Sarika Gupta, MBBS,* Benedict Yan, MBBS,* Pay Chin Leow, PhD,w Sze Yung Chin, BSc,* Richie Soong, PhD,*w and Fredrik Petersson, MD, PhD* right testicular swelling measuring 433 cm. Routine Abstract: We report a case of primary epididymal mucinous laboratory investigations, including carcinoembryonic anti- adenocarcinoma in a 60-year-old man who presented with a gen, b-chorionic gonadotropin, a-fetoprotein, and prostate- scrotal mass and subsequently developed pulmonary metastases. specific antigen were normal, and urine culture was negative. On immunohistochemistry the tumor was positive for villin and An ultrasound examination showed a normal-sized right CK20 and negative for CK7, CDX2, and thyroid transcription testis with an ill-defined heterogeneous mass measuring factor-1. Molecular genetic analysis revealed an uncommon 2.41.5 cm, showing punctuate microcalcifications located mutation; 249: AGG -ATG in the TP53 gene, which has not near the upper pole. In addition, there was an associated been previously described in association with a primary epididy- ipsilateral hydrocele and multiple cysts (less than 1 cm in mal adenocarcinoma. Mutational analysis showed KRAS, maximum dimension) in the epididymal head. The left BRAF,and VHL
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Apr 1, 2015
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