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Primary Lung Adenocarcinomas in Children and Adolescents Treated for Pediatric Malignancies

Primary Lung Adenocarcinomas in Children and Adolescents Treated for Pediatric Malignancies ORIGINAL ARTICLE Primary Lung Adenocarcinomas in Children and Adolescents Treated for Pediatric Malignancies Mark L. Kayton, MD,* Mai He, MD, PhD,† Maureen F. Zakowski, MD,† Andre L. Moreira, MD, PhD,† Christopher Lau, PhD,† Alexander J. Chou, MD,‡ Melinda Merchant, MD, PhD,‡ Pamela R. Merola, MD,‡ Leonard H. Wexler, MD,‡ Michael P. La Quaglia, MD,* William D. Travis, MD,† and Marc Ladanyi, MD†§ rimary adenocarcinoma of the lung is exceedingly rare in Introduction: Primary lung adenocarcinoma is extremely rare in the Ppediatric patients. In 1982, a review of the 230 pediatric pediatric age group. There have been anecdotal reports of lesions cases from the English-language literature identified only that are histologically indistinguishable from adult-type pulmonary 47 classifiable as “bronchogenic carcinoma.” Although a adenocarcinoma in young patients after treatment for nonpulmonary small number of sporadic pulmonary adenocarcinomas cancers. Herein, we present clinical, histopathologic, and molecular 2–5 have been reported since then, the preponderance have data on eight such cases. been found in conjunction with congenital cystic adeno- Methods: Histopathologic evaluation of the tumors was performed 6 –16 matoid malformations (CCAM) of the lung. Beyond according to the World Health Organization classification. Molecu- this, given the scarcity of cases, it has not http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Primary Lung Adenocarcinomas in Children and Adolescents Treated for Pediatric Malignancies

Ladanyi, Marc
Journal of Thoracic Oncology , Volume 5 (11) – Nov 1, 2010
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References (50)

ISSN
1556-0864
DOI
10.1097/JTO.0b013e3181f69f08
pmid
20975376
Publisher site
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Abstract

ORIGINAL ARTICLE Primary Lung Adenocarcinomas in Children and Adolescents Treated for Pediatric Malignancies Mark L. Kayton, MD,* Mai He, MD, PhD,† Maureen F. Zakowski, MD,† Andre L. Moreira, MD, PhD,† Christopher Lau, PhD,† Alexander J. Chou, MD,‡ Melinda Merchant, MD, PhD,‡ Pamela R. Merola, MD,‡ Leonard H. Wexler, MD,‡ Michael P. La Quaglia, MD,* William D. Travis, MD,† and Marc Ladanyi, MD†§ rimary adenocarcinoma of the lung is exceedingly rare in Introduction: Primary lung adenocarcinoma is extremely rare in the Ppediatric patients. In 1982, a review of the 230 pediatric pediatric age group. There have been anecdotal reports of lesions cases from the English-language literature identified only that are histologically indistinguishable from adult-type pulmonary 47 classifiable as “bronchogenic carcinoma.” Although a adenocarcinoma in young patients after treatment for nonpulmonary small number of sporadic pulmonary adenocarcinomas cancers. Herein, we present clinical, histopathologic, and molecular 2–5 have been reported since then, the preponderance have data on eight such cases. been found in conjunction with congenital cystic adeno- Methods: Histopathologic evaluation of the tumors was performed 6 –16 matoid malformations (CCAM) of the lung. Beyond according to the World Health Organization classification. Molecu- this, given the scarcity of cases, it has not

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Nov 1, 2010

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