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Primary Intestinal Diffuse Large B-cell Lymphoma in Taiwan Showed a Relative Higher Rate of Perforation and EBV Association

Primary Intestinal Diffuse Large B-cell Lymphoma in Taiwan Showed a Relative Higher Rate of... RESEARCH ARTICLE Primary Intestinal Diffuse Large B-cell Lymphoma in Taiwan Showed a Relative Higher Rate of Perforation and EBV Association Yi-Hsuan Lu, MD,* Sheng-Tsung Chang, MD,wz Sheau-Fang Yang, MD,y Shih-Feng Weng, PhD,8 Wan-Ting Huang, MD, PhD,z# Pin-Pen Hsieh, MD,** Jeng-Dong Hsu, DMD, MD,ww Mei-Hua Tsou, MD,zz and Shih-Sung Chuang, MDwyy respectively. Seven (12%) of 59 cases were positive for Epstein- Abstract: We retrospectively investigated 59 surgically resected Barr virus (EBV) by in situ hybridization. IGH, BCL2, BCL6, primary intestinal diffuse large B-cell lymphomas (PI-DLBCL) and MYC foci were rearranged in 22%, 3%, 17%, and 7% including 31 males and 28 females with a median age of 66. cases, respectively, with 14% exhibiting gain/amplification at the Eleven (19%) tumors were perforated at presentation; 8 (14%) MYC locus. Perforation (P = 0.009), high ECOG PS (Z2) were multicentric. Ileum (n = 24; 43%) and ileocecum (n = 17; (P = 0.018), and no adjuvant chemotherapy (P < 0.001) were 30%) were most frequently involved. Twenty-one (36%) poor prognostic factors but not immunophenotype including co- patients did not receive chemotherapy or radiotherapy including expression of bcl-2 and myc, EBV status, or chromosomal 6 with perforation and died in 0.2 to 7 months. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Primary Intestinal Diffuse Large B-cell Lymphoma in Taiwan Showed a Relative Higher Rate of Perforation and EBV Association

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Aug 1, 2015

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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000226
pmid
26258754
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Primary Intestinal Diffuse Large B-cell Lymphoma in Taiwan Showed a Relative Higher Rate of Perforation and EBV Association Yi-Hsuan Lu, MD,* Sheng-Tsung Chang, MD,wz Sheau-Fang Yang, MD,y Shih-Feng Weng, PhD,8 Wan-Ting Huang, MD, PhD,z# Pin-Pen Hsieh, MD,** Jeng-Dong Hsu, DMD, MD,ww Mei-Hua Tsou, MD,zz and Shih-Sung Chuang, MDwyy respectively. Seven (12%) of 59 cases were positive for Epstein- Abstract: We retrospectively investigated 59 surgically resected Barr virus (EBV) by in situ hybridization. IGH, BCL2, BCL6, primary intestinal diffuse large B-cell lymphomas (PI-DLBCL) and MYC foci were rearranged in 22%, 3%, 17%, and 7% including 31 males and 28 females with a median age of 66. cases, respectively, with 14% exhibiting gain/amplification at the Eleven (19%) tumors were perforated at presentation; 8 (14%) MYC locus. Perforation (P = 0.009), high ECOG PS (Z2) were multicentric. Ileum (n = 24; 43%) and ileocecum (n = 17; (P = 0.018), and no adjuvant chemotherapy (P < 0.001) were 30%) were most frequently involved. Twenty-one (36%) poor prognostic factors but not immunophenotype including co- patients did not receive chemotherapy or radiotherapy including expression of bcl-2 and myc, EBV status, or chromosomal 6 with perforation and died in 0.2 to 7 months.

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Aug 1, 2015

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