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Primary cell models of HIV latency

Primary cell models of HIV latency Hung-Chih Yang Department of Microbiology, National Taiwan Purpose of review University College of Medicine and National Taiwan To provide updated points of view regarding the recent development and application University Hospital, Taipei, Taiwan of in-vitro primary cell models of HIV latency and their potential application in future Correspondence to Hung-Chih Yang, MD, PhD, Basic studies of HIV eradication. Medical Sciences Building, Room 724, 1Jen-Ai Road, Section 1, Taipei 10051, Taiwan Recent findings Tel: +886 2 2312 3456 x66681; It has been challenging to develop a primary cell model of HIV latency that can fax: +886 2 2370 9820; e-mail: hcyang88@ntu.edu.tw authentically recapitulate the quiescent features of resting CD4 T cells. Recently, several articles have described different approaches that can generate latently Current Opinion in HIV and AIDS 2011, 6:62–67 HIV-infected resting CD4 T cells in vitro. Some of them further demonstrated that the primary cell models of HIV latency are suitable for biochemical studies and drug screening. Summary Recent progress in primary cell models of HIV latency has facilitated research on the mechanisms of HIV latency. These models also serve as a platform for the discovery of drugs that can purge the latent reservoir for HIV in resting CD4 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Primary cell models of HIV latency

Yang, Hung-Chih
Current Opinion in HIV and Aids , Volume 6 (1) – Jan 1, 2011
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References (52)

ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e3283412568
pmid
21242895
Publisher site
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Abstract

Hung-Chih Yang Department of Microbiology, National Taiwan Purpose of review University College of Medicine and National Taiwan To provide updated points of view regarding the recent development and application University Hospital, Taipei, Taiwan of in-vitro primary cell models of HIV latency and their potential application in future Correspondence to Hung-Chih Yang, MD, PhD, Basic studies of HIV eradication. Medical Sciences Building, Room 724, 1Jen-Ai Road, Section 1, Taipei 10051, Taiwan Recent findings Tel: +886 2 2312 3456 x66681; It has been challenging to develop a primary cell model of HIV latency that can fax: +886 2 2370 9820; e-mail: hcyang88@ntu.edu.tw authentically recapitulate the quiescent features of resting CD4 T cells. Recently, several articles have described different approaches that can generate latently Current Opinion in HIV and AIDS 2011, 6:62–67 HIV-infected resting CD4 T cells in vitro. Some of them further demonstrated that the primary cell models of HIV latency are suitable for biochemical studies and drug screening. Summary Recent progress in primary cell models of HIV latency has facilitated research on the mechanisms of HIV latency. These models also serve as a platform for the discovery of drugs that can purge the latent reservoir for HIV in resting CD4

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Jan 1, 2011

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