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Prevention and treatment of the immune reconstitution inflammatory syndrome

Prevention and treatment of the immune reconstitution inflammatory syndrome Prevention and treatment of the immune reconstitution inflammatory syndrome a,b c Graeme Meintjes and Lut Lynen Institute of Infectious Diseases and Molecular Purpose of review Medicine and Department of Medicine, University of b The immune reconstitution inflammatory syndrome occurs in a proportion of HIV- Cape Town, GF Jooste Hospital, Cape Town, South Africa and Prince Leopold Institute of Tropical infected patients initiated on combination antiretroviral therapy and results from Medicine, Antwerp, Belgium dysregulated inflammatory responses driven by the recovering immune system. Infective Correspondence to Graeme Meintjes, GF Jooste forms may manifest as the unmasking of preexisting untreated opportunistic Hospital, Duinefontein Road, Manenberg, 7764, infections or the paradoxical clinical deterioration of appropriately treated opportunistic South Africa Tel: +27 21 6901000; fax: +27 21 6920289; infections. The prevention and treatment of this condition is the focus of much e-mail: graemein@mweb.co.za research attention, which is the scope of this review. Recent findings Current Opinion in HIV and AIDS 2008, 3:468– Approaches to prevention are informed by studies that have reported on risk factors, particularly those that are modifiable. Two key ongoing research issues are optimal screening for opportunistic infections prior to combination antiretroviral therapy in order to prevent unmasking forms and the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Prevention and treatment of the immune reconstitution inflammatory syndrome

Current Opinion in HIV and Aids , Volume 3 (4) – Jul 1, 2008

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References (124)

ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e3282fe6e84
pmid
19373007
Publisher site
See Article on Publisher Site

Abstract

Prevention and treatment of the immune reconstitution inflammatory syndrome a,b c Graeme Meintjes and Lut Lynen Institute of Infectious Diseases and Molecular Purpose of review Medicine and Department of Medicine, University of b The immune reconstitution inflammatory syndrome occurs in a proportion of HIV- Cape Town, GF Jooste Hospital, Cape Town, South Africa and Prince Leopold Institute of Tropical infected patients initiated on combination antiretroviral therapy and results from Medicine, Antwerp, Belgium dysregulated inflammatory responses driven by the recovering immune system. Infective Correspondence to Graeme Meintjes, GF Jooste forms may manifest as the unmasking of preexisting untreated opportunistic Hospital, Duinefontein Road, Manenberg, 7764, infections or the paradoxical clinical deterioration of appropriately treated opportunistic South Africa Tel: +27 21 6901000; fax: +27 21 6920289; infections. The prevention and treatment of this condition is the focus of much e-mail: graemein@mweb.co.za research attention, which is the scope of this review. Recent findings Current Opinion in HIV and AIDS 2008, 3:468– Approaches to prevention are informed by studies that have reported on risk factors, particularly those that are modifiable. Two key ongoing research issues are optimal screening for opportunistic infections prior to combination antiretroviral therapy in order to prevent unmasking forms and the

Journal

Current Opinion in HIV and AidsWolters Kluwer Health

Published: Jul 1, 2008

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