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- Publisher
- Wolters Kluwer Health
- Copyright
- © 2022 by American Society of Clinical Oncology
- eISSN
- 2473-4276
- DOI
- 10.1200/cci.21.00152
- Publisher site
- See Article on Publisher Site
Abstract
PURPOSEThe rapid growth of biomedical data ecosystems has catalyzed research for oncology and precision medicine. We leverage federal cloud-based precision medicine databases and tools to better understand the current landscape of precision medicine and genomic testing for patients with cancer.METHODSRetrospective observational study of genomic testing for patients with cancer in the National Institutes of Health All of Us Research Program, with the cancer cohort defined as having at least two documented or reported cancer diagnoses.RESULTSThere were 5,678 (1.8%) All of Us participants in the cancer cohort, with a significant difference between cancer status by age category, sex, race, and ethnicity (P < .001 for all). There were 295 (5.2%) patients with cancer who received genomic testing compared with 6,734 (2.2%) of noncancer patients, with 752 genomic tests commonly focused on gene mutations (primarily pharmacogenomics), molecular pathology, or clinical cytogenetic reports.CONCLUSIONAlthough not yet ubiquitous, diverse clinical genomic analyses in oncology can set the stage to grow the practice of precision medicine by integrating research patient data repositories, cancer data ecosystems, and biomedical informatics.
Journal
JCO: Clinical Cancer Informatics – Wolters Kluwer Health
Published: Jan 5, 2022