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Precision medicine in cow's milk allergy

Precision medicine in cow's milk allergy Downloaded from http://journals.lww.com/co-allergy by BhDMf5ePHKbH4TTImqenVJ2toCr/9wZZjwPUWvYES9l2nY+zyylnl33NGMK6MRsx on 10/02/2020 REVIEW URRENT PINION a b Enza D’Auria and Carina Venter Purpose of review The aim of this review is to describe the role of precision medicine in the diagnosis, treatment, and monitoring of cow’s milk allergy. Recent findings The development of ‘omics’ sciences in the field of food allergy has led to a better understanding of the allergenicity of cow’s milk proteins and significant advances in the knowledge of the pathogenesis and mechanisms of cow’s milk allergy. Omics-based technologies allow the practitioner to better differentiate cow’s milk allergy subtypes and to predict cow’s milk allergy (CMA) persistence over time. Precision medicine extends the role of the oral food challenge, to determine the individual’s threshold doses, and to establish tolerance to baked milk products. Other than symptom relief, dietary strategies are currently being investigated for the potential to induce tolerance. Oral immunotherapy offers a treatment option for patients with severe and persistent IgE-mediated CMA. Individual baseline-immune profiles may be predictive of cow’s milk oral immunotherapy safety and efficacy. Patient data derived from current technology, in combination with the patient’s history, can be translated into treatments targeted at patient-tailored interventions. Summary The identification of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy & Clinical Immunology Wolters Kluwer Health

Precision medicine in cow's milk allergy

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References (114)

Publisher
Wolters Kluwer Health
Copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0000000000000640
Publisher site
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Abstract

Downloaded from http://journals.lww.com/co-allergy by BhDMf5ePHKbH4TTImqenVJ2toCr/9wZZjwPUWvYES9l2nY+zyylnl33NGMK6MRsx on 10/02/2020 REVIEW URRENT PINION a b Enza D’Auria and Carina Venter Purpose of review The aim of this review is to describe the role of precision medicine in the diagnosis, treatment, and monitoring of cow’s milk allergy. Recent findings The development of ‘omics’ sciences in the field of food allergy has led to a better understanding of the allergenicity of cow’s milk proteins and significant advances in the knowledge of the pathogenesis and mechanisms of cow’s milk allergy. Omics-based technologies allow the practitioner to better differentiate cow’s milk allergy subtypes and to predict cow’s milk allergy (CMA) persistence over time. Precision medicine extends the role of the oral food challenge, to determine the individual’s threshold doses, and to establish tolerance to baked milk products. Other than symptom relief, dietary strategies are currently being investigated for the potential to induce tolerance. Oral immunotherapy offers a treatment option for patients with severe and persistent IgE-mediated CMA. Individual baseline-immune profiles may be predictive of cow’s milk oral immunotherapy safety and efficacy. Patient data derived from current technology, in combination with the patient’s history, can be translated into treatments targeted at patient-tailored interventions. Summary The identification of

Journal

Current Opinion in Allergy & Clinical Immunology – Wolters Kluwer Health

Published: Jun 1, 2020

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