Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of Alzheimer's Disease in Ecuadorian Population

Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of... CLINICAL INVESTIGATION Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of Alzheimer’s Disease in Ecuadorian Population César Paz-y-Miño, MD, Jennyfer M. García-Cárdenas, MSc, Andrés López-Cortés, BSc, Carolina Salazar, MSc, Marcos Serrano, MD and Paola E. Leone, PhD instance, when comparing Cystic Fibrosis, the incidence in Abstract: Background: Alzheimer’s disease (AD) is the most common Latin America is 1/10,000, whereas in whites the incidence is cause of senile dementia. In Ecuador, the number of deaths caused by 1/2,000. In Ecuador, only 150 cases have been reported. AD increases each year. Epidemiologically, the Ecuadorian population AD begins with subtle memory loss, which progresses to is composed of a mixture of several genetic backgrounds along with a more severe, irreversible and incapacitating form. Other environmental factors, that make it unique and ideal for population symptoms include confusion, poor judgment, language prob- studies. The main objective of this study was to determine the preva- lems and hallucinations, among others. In the brain, cerebral lence of Cystatin C (CST3), Cathepsin D (CTSD) and Manganese cortical atrophy is a product of intraneural neurofibrillary tan- superoxide dismutase (MnSOD) amino acid-altering polymorphisms gles and large extracellular accumulations of amyloid b (Ab)in and their http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of the Medical Sciences Wolters Kluwer Health

Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of Alzheimer's Disease in Ecuadorian Population

Leone, Paola E.
American Journal of the Medical Sciences , Volume Publish Ahead of Print – Sep 1, 2015
Download PDF
6 pages

Loading next page...
 
/lp/wolters-kluwer-health/positive-association-of-the-cathepsin-d-ala224val-gene-polymorphism-QflP3Las9s

References (46)

Copyright
Copyright © 2015 by the Southern Society for Clinical Investigation.
ISSN
0002-9629
eISSN
1538-2990
DOI
10.1097/MAJ.0000000000000555
pmid
26351775
Publisher site
See Article on Publisher Site

Abstract

CLINICAL INVESTIGATION Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of Alzheimer’s Disease in Ecuadorian Population César Paz-y-Miño, MD, Jennyfer M. García-Cárdenas, MSc, Andrés López-Cortés, BSc, Carolina Salazar, MSc, Marcos Serrano, MD and Paola E. Leone, PhD instance, when comparing Cystic Fibrosis, the incidence in Abstract: Background: Alzheimer’s disease (AD) is the most common Latin America is 1/10,000, whereas in whites the incidence is cause of senile dementia. In Ecuador, the number of deaths caused by 1/2,000. In Ecuador, only 150 cases have been reported. AD increases each year. Epidemiologically, the Ecuadorian population AD begins with subtle memory loss, which progresses to is composed of a mixture of several genetic backgrounds along with a more severe, irreversible and incapacitating form. Other environmental factors, that make it unique and ideal for population symptoms include confusion, poor judgment, language prob- studies. The main objective of this study was to determine the preva- lems and hallucinations, among others. In the brain, cerebral lence of Cystatin C (CST3), Cathepsin D (CTSD) and Manganese cortical atrophy is a product of intraneural neurofibrillary tan- superoxide dismutase (MnSOD) amino acid-altering polymorphisms gles and large extracellular accumulations of amyloid b (Ab)in and their

Journal

American Journal of the Medical Sciences – Wolters Kluwer Health

Published: Sep 1, 2015

There are no references for this article.