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ORIGINAL ARTICLE Polymorphisms in the Caspase Genes and the Risk of Lung Cancer Shin Yup Lee, MD,* Yi Young Choi, MS,† Jin Eun Choi, PhD,† Min Jung Kim, BS,† Jong-Sik Kim, BS,† Deuk Kju Jung, MS,† Hyo-Gyoung Kang, MS,† Hyo-Sung Jeon, PhD,† Won Kee Lee, PhD,‡ Guang Jin, BS,†§ Seung Ick Cha, MD,* Chang Ho Kim, MD,* Tae Hoon Jung, MD,* and Jae Yong Park, MD, PhD*† poptosis is a genetically controlled process of pro- Introduction: Caspases (CASPs) are important regulators and ex- Agrammed cell death, which plays an important role in the ecutioners in apoptosis pathway and play a crucial role in the 1–3 development and homeostasis of cells and tissues. Defects development and progression of cancer. On the basis of the inter- in the apoptosis pathway may facilitate the accumulation of actions of CASPs in the apoptotic pathway, we evaluated the somatic mutations, thereby increasing the risk of cancers, association between 11 polymorphisms of CASP3, 6, 7, 8, 9, and 10 4,5 including lung cancer. Caspases (CASPs), a family of genes and the risk of lung cancer. cysteine-dependent aspartate-specific proteases, are the cen- Methods: The genotypes were determined in 720 patients with tral engines of apoptosis that
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Aug 1, 2010
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