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Polygenic risk scores for the diagnosis and management of dyslipidemia

Polygenic risk scores for the diagnosis and management of dyslipidemia Purpose of reviewTo review current progress in the use of polygenic risk scores for lipid traits and their use in the diagnosis and treatment of lipid disorders.Recent findingsInherited lipid disorders, including those causing extremes of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, or triglycerides were initially identified as monogenic traits, in which a single rare variant with large effect size is responsible for the phenotype. More recently, a polygenic basis for many lipid traits has also been identified. Patients with polygenic dyslipidemia can be identified through the use of polygenic risk scores (PRSs), which collapse information from a handful to several million genetic variants into a single metric.SummaryPRSs for lipid traits may aid in the identification of the genetic basis for the lipid phenotype in individual patients, may provide additional information regarding the risk of cardiovascular disease, and could help in guiding therapeutic decision making. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Endocrinology Diabetes and Obesity Wolters Kluwer Health

Polygenic risk scores for the diagnosis and management of dyslipidemia

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1752-296X
eISSN
1752-2978
DOI
10.1097/med.0000000000000708
Publisher site
See Article on Publisher Site

Abstract

Purpose of reviewTo review current progress in the use of polygenic risk scores for lipid traits and their use in the diagnosis and treatment of lipid disorders.Recent findingsInherited lipid disorders, including those causing extremes of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, or triglycerides were initially identified as monogenic traits, in which a single rare variant with large effect size is responsible for the phenotype. More recently, a polygenic basis for many lipid traits has also been identified. Patients with polygenic dyslipidemia can be identified through the use of polygenic risk scores (PRSs), which collapse information from a handful to several million genetic variants into a single metric.SummaryPRSs for lipid traits may aid in the identification of the genetic basis for the lipid phenotype in individual patients, may provide additional information regarding the risk of cardiovascular disease, and could help in guiding therapeutic decision making.

Journal

Current Opinion in Endocrinology Diabetes and ObesityWolters Kluwer Health

Published: Apr 15, 2022

References