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Podoplanin is Positive Not Only on Follicular Dendritic Cells and Their Tumoral Counterparts, But Also on Reticular Fibroblasts and in Some Tumors of Reticular Fibroblasts

Podoplanin is Positive Not Only on Follicular Dendritic Cells and Their Tumoral Counterparts, But... LETTER TO THE EDITOR 5,6 1,7 of FBRCs. In 1 case of tumor of cells,” although it may also be ex- Podoplanin is Positive 5 4,6 FBRCs reported by Dong et al, Ppl pressed in tumors of FBRCs. Not Only on Follicular resulted negative. In contrast, we have However, the tumors of follicular recently described a tumor of FBRCs dendritic cells present expression of Dendritic Cells and Their of lymph node that showed zonal other markers such as CD21, CD23, staining for Ppl (D2-40), being and CD35, which are not expressed in Tumoral Counterparts, stronger in cortical areas and lighter tumors of FBRCs. In contrast, they But Also on Reticular in paracortex. are negative with AE1-AE3 and 18 The opposite results of staining cytokeratins and other antigens usu- Fibroblasts and in Some for Ppl in these 2 cases of tumors of ally positive in tumors derived from FBRCs is not easy to justify. In both FBRCs. Tumors of Reticular studies, the same antibody and the Dimas Sua´ rez-Vilela, MD* Fibroblasts same antigen retrieval system with Francisco M. Izquierdo, MD, PhDw autoclave and 1 mmol/L EDTA under *Department of Pathology, Hospital Valle To the Editor: a pH 8.0 was used. Our D2-40 anti- del Nalo´ n, Polı´ gono de Rian˜ o, Asturias We have read the interesting body was prediluted, whereas that of wDepartment of Pathology, Complejo review of Dr Ordon˜ ez referred to the Dong et al was used with a 1/250 Asistencial Universitario de Leo´ n value of podoplanin (Ppl) for the di- dilution. It is possible that not all Leo´ n, Spain agnosis of different tumors. Ppl is a FBRCs express Ppl and therefore the good marker of follicular dendritic tumors derived from these cells could REFERENCES cells that are localized in the germinal also be negative. Nevertheless, as this 1. Ordo´ n˜ ez NG. Value of podoplanin as an center of the lymphoid follicles. As it antibody has been used in only 2 cases immunohistochemical marker in tumor di- agnosis: a review and update. Appl Immuno- is commented in his article, it is not of this uncommon tumor, we believe histochem Mol Morphol. 2014;22:331–347. expressed either by the reactive lym- that it is not warranted to be con- 2. Buetner M, Pabst R, Bode U. Stromal cell phocytes or by lymphomatous cells. clusive at this point. In addition, our heterogeneity in lymphoid organs. Trends Nevertheless, in the secondary lym- tumor was positive for vimentin, Immunol. 2010;31:80–86. 3. Roozendal R, Mebius RE. Stromal cell- phoid organs, Ppl also stains the AE1-AE3 and 18 cytokeratins, CD10, 2,3 immune cell interactions. Annu Rev Immu- reticular fibroblasts (FBRCs). CNA42, a-1-antitrypsin and, in iso- nol. 2011;29:23–43. FBRCs are stromal cells located in lated cells, EMA, being negative for 4. Sua´ rez-Vilela D, Izquierdo FM, Me´ ndez- the parafollicular area and deep cor- CD21, CD23, and CD35. Alvarez JR, et al. Neoplams of dendritic We think that before a neo- tex of lymph nodes and extrafollicular cells: related cell origins and diagnostic markers. Fibroblastic reticulum cells and plasm suggestive of a “dendritic cell” areas of the spleen and tonsils. fibroblastic reticulum cell tumors show origin a wide panel of antibodies FBRCs are not a simple supportive several immunophenotypic profiles. Hum should be used, including Ppl. We stromal structure in secondary lym- Pathol. 2012;43:1530–1532. consider follicular dendritic cell sar- phoid organs, but they are involved in 5. Dong YC, Wu B, Sheng Z, et al. Cytoker- coma, histiocytic sarcoma, FBRCs atin-positive interstitial reticulum cell tu- transport of soluble antigens and in 2,3 mors of lymph nodes: a case report and tumor, indeterminate dendritic cell T-lymphocytes recirculation. The review of literature. Chin Med J. 2008; tumor and dendritic cell tumor NOS tumors presumptively derived from 121:658–663. in this group of “dendritic cell” neo- FBRCs are very uncommon neo- 6. Sua´ rez-Vilela D, Izquierdo FM, Me´ ndez JR, plasms. The result of this antibody plasms that may show a microscopic et al. Tumor of fibroblastic reticular cells of lymph node coincidental with an undiffer- must be combined with those of other appearance very similar to the tumors entiated endometrial stromal sarcoma. Re- markers such as CD21, CD23, CD35, of follicular dendritic cells. These tu- port of a case with an undifferentiated CNA42, S100, cytokeratins, and moral proliferations present a het- endometrial stromal sarcoma. Report of a smooth muscle actin to get a correct erogenous immunophenotype and case with distinctive immunophenotype and diagnosis for these rare tumors. On Kikuchi-like necro-inflammatory response. may be positive for AE1-AE3 and APMIS. 2011;119:216–220. this topic, it is mandatory to keep in Cam5.2 cytokeratins, smooth muscle 7. Yu H, Gibson JA, Pinkus GS, et al. mind that Ppl is positive in most of actin, desmin, and other antigens. Podoplanin (D2-40) is a novel marker for follicular dendritic cell sarcomas and However, the expression of Ppl has follicular dendritic cell tumors. Am J Clin negative in other tumors of “dendritic been studied in a few cases of tumors Pathol. 2007;128:776–782. The authors declare no conflict of interest. Appl Immunohistochem Mol Morphol Volume 00, Number 00, ’’ 2014 www.appliedimmunohist.com 1 Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Podoplanin is Positive Not Only on Follicular Dendritic Cells and Their Tumoral Counterparts, But Also on Reticular Fibroblasts and in Some Tumors of Reticular Fibroblasts

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Dec 1, 2014

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Copyright
Copyright © 2014 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000142
pmid
25493707
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Abstract

LETTER TO THE EDITOR 5,6 1,7 of FBRCs. In 1 case of tumor of cells,” although it may also be ex- Podoplanin is Positive 5 4,6 FBRCs reported by Dong et al, Ppl pressed in tumors of FBRCs. Not Only on Follicular resulted negative. In contrast, we have However, the tumors of follicular recently described a tumor of FBRCs dendritic cells present expression of Dendritic Cells and Their of lymph node that showed zonal other markers such as CD21, CD23, staining for Ppl (D2-40), being and CD35, which are not expressed in Tumoral Counterparts, stronger in cortical areas and lighter tumors of FBRCs. In contrast, they But Also on Reticular in paracortex. are negative with AE1-AE3 and 18 The opposite results of staining cytokeratins and other antigens usu- Fibroblasts and in Some for Ppl in these 2 cases of tumors of ally positive in tumors derived from FBRCs is not easy to justify. In both FBRCs. Tumors of Reticular studies, the same antibody and the Dimas Sua´ rez-Vilela, MD* Fibroblasts same antigen retrieval system with Francisco M. Izquierdo, MD, PhDw autoclave and 1 mmol/L EDTA under *Department of Pathology, Hospital Valle To the Editor: a pH 8.0 was used. Our D2-40 anti- del Nalo´ n, Polı´ gono de Rian˜ o, Asturias We have read the interesting body was prediluted, whereas that of wDepartment of Pathology, Complejo review of Dr Ordon˜ ez referred to the Dong et al was used with a 1/250 Asistencial Universitario de Leo´ n value of podoplanin (Ppl) for the di- dilution. It is possible that not all Leo´ n, Spain agnosis of different tumors. Ppl is a FBRCs express Ppl and therefore the good marker of follicular dendritic tumors derived from these cells could REFERENCES cells that are localized in the germinal also be negative. Nevertheless, as this 1. Ordo´ n˜ ez NG. Value of podoplanin as an center of the lymphoid follicles. As it antibody has been used in only 2 cases immunohistochemical marker in tumor di- agnosis: a review and update. Appl Immuno- is commented in his article, it is not of this uncommon tumor, we believe histochem Mol Morphol. 2014;22:331–347. expressed either by the reactive lym- that it is not warranted to be con- 2. Buetner M, Pabst R, Bode U. Stromal cell phocytes or by lymphomatous cells. clusive at this point. In addition, our heterogeneity in lymphoid organs. Trends Nevertheless, in the secondary lym- tumor was positive for vimentin, Immunol. 2010;31:80–86. 3. Roozendal R, Mebius RE. Stromal cell- phoid organs, Ppl also stains the AE1-AE3 and 18 cytokeratins, CD10, 2,3 immune cell interactions. Annu Rev Immu- reticular fibroblasts (FBRCs). CNA42, a-1-antitrypsin and, in iso- nol. 2011;29:23–43. FBRCs are stromal cells located in lated cells, EMA, being negative for 4. Sua´ rez-Vilela D, Izquierdo FM, Me´ ndez- the parafollicular area and deep cor- CD21, CD23, and CD35. Alvarez JR, et al. Neoplams of dendritic We think that before a neo- tex of lymph nodes and extrafollicular cells: related cell origins and diagnostic markers. Fibroblastic reticulum cells and plasm suggestive of a “dendritic cell” areas of the spleen and tonsils. fibroblastic reticulum cell tumors show origin a wide panel of antibodies FBRCs are not a simple supportive several immunophenotypic profiles. Hum should be used, including Ppl. We stromal structure in secondary lym- Pathol. 2012;43:1530–1532. consider follicular dendritic cell sar- phoid organs, but they are involved in 5. Dong YC, Wu B, Sheng Z, et al. Cytoker- coma, histiocytic sarcoma, FBRCs atin-positive interstitial reticulum cell tu- transport of soluble antigens and in 2,3 mors of lymph nodes: a case report and tumor, indeterminate dendritic cell T-lymphocytes recirculation. The review of literature. Chin Med J. 2008; tumor and dendritic cell tumor NOS tumors presumptively derived from 121:658–663. in this group of “dendritic cell” neo- FBRCs are very uncommon neo- 6. Sua´ rez-Vilela D, Izquierdo FM, Me´ ndez JR, plasms. The result of this antibody plasms that may show a microscopic et al. Tumor of fibroblastic reticular cells of lymph node coincidental with an undiffer- must be combined with those of other appearance very similar to the tumors entiated endometrial stromal sarcoma. Re- markers such as CD21, CD23, CD35, of follicular dendritic cells. These tu- port of a case with an undifferentiated CNA42, S100, cytokeratins, and moral proliferations present a het- endometrial stromal sarcoma. Report of a smooth muscle actin to get a correct erogenous immunophenotype and case with distinctive immunophenotype and diagnosis for these rare tumors. On Kikuchi-like necro-inflammatory response. may be positive for AE1-AE3 and APMIS. 2011;119:216–220. this topic, it is mandatory to keep in Cam5.2 cytokeratins, smooth muscle 7. Yu H, Gibson JA, Pinkus GS, et al. mind that Ppl is positive in most of actin, desmin, and other antigens. Podoplanin (D2-40) is a novel marker for follicular dendritic cell sarcomas and However, the expression of Ppl has follicular dendritic cell tumors. Am J Clin negative in other tumors of “dendritic been studied in a few cases of tumors Pathol. 2007;128:776–782. The authors declare no conflict of interest. Appl Immunohistochem Mol Morphol Volume 00, Number 00, ’’ 2014 www.appliedimmunohist.com 1 Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Dec 1, 2014

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