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Platelet with Function and Survival in Patients Severe Hypercholesterolemia

Platelet with Function and Survival in Patients Severe Hypercholesterolemia Platelet aggregation and survival were measured in twelve subjects with severe hypercholesterolemia. There was a small increase in sensitivity to epinephrine and adenosine diphosphate among the most hypercholesterolemic patients, but this did not correlate with reduced platelet lifespan. Platelet survival was normal or only moderately reduced In the markedly hypercholesterolemic homozygous subjects. However, the Incidence of reduced platelet survival was significantly increased (p< 0.05) among the older patients with more extensive atherosclerotic vascular disease compared to the younger patients with limited vascular disease. Marked hypercholesterolemia in the absence of atherosclerosis does not appear to accelerate platelet destruction, although a modest Increased aggregability is present. (Arteriosclerosis 1:443-448, November&sol;December 1981) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Platelet with Function and Survival in Patients Severe Hypercholesterolemia

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Copyright
© 1981 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

Platelet aggregation and survival were measured in twelve subjects with severe hypercholesterolemia. There was a small increase in sensitivity to epinephrine and adenosine diphosphate among the most hypercholesterolemic patients, but this did not correlate with reduced platelet lifespan. Platelet survival was normal or only moderately reduced In the markedly hypercholesterolemic homozygous subjects. However, the Incidence of reduced platelet survival was significantly increased (p< 0.05) among the older patients with more extensive atherosclerotic vascular disease compared to the younger patients with limited vascular disease. Marked hypercholesterolemia in the absence of atherosclerosis does not appear to accelerate platelet destruction, although a modest Increased aggregability is present. (Arteriosclerosis 1:443-448, November&sol;December 1981)

Journal

ArteriosclerosisWolters Kluwer Health

Published: Nov 1, 1981

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