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PI3K/mTOR Signaling in Mesothelioma Patients Treated with Induction Chemotherapy Followed by Extrapleural Pneumonectomy

PI3K/mTOR Signaling in Mesothelioma Patients Treated with Induction Chemotherapy Followed by... ORIGINAL ARTICLE PI3K/mTOR Signaling in Mesothelioma Patients  Treated with Induction Chemotherapy Followed by  Extrapleural Pneumonectomy Byron K.Y. Bitanihirwe, PhD,* Mayura Meerang, PhD,* Martina Friess, VMD,* Alex Soltermann, MD,† Lukas Frischknecht, MD,† Svenja Thies, MD,† Emanuela Felley-Bosco, PhD,‡ Ming-Sound Tsao, MD,§ Ghassan Allo, MD,§ Marc de Perrot, MD,║ Burkhardt Seifert, PhD,¶ Holger Moch, MD,† Rolf Stahel MD,‡ Walter Weder MD,* and Isabelle Opitz, MD* expression in samples before and after induction chemotherapy of Introduction: The prognostic significance of activity biomarkers cohort 1 revealed that decreased cytoplasmic PTEN and increased within the phosphatidylinositol 3-kinase (PI3K)/mammalian target phospho-mTOR expression was associated with a worse OAS of rapamycin (mTOR) signaling pathway was assessed in two inde- (p = 0.04 and p = 0.03, respectively). pendent cohorts of malignant pleural mesothelioma (MPM) patients Conclusions: These novel data reveal a prognostic significance of uniformly treated with a multimodal approach. We specifically expression changes of PI3K/mTOR pathway components during assessed expression signatures in a unique set of pre- and postchemo- induction chemotherapy if confirmed in other patient cohorts and therapy tumor samples. support the growing evidence to target the PI3K/mTOR pathway in Methods: Biomarker expression was assessed in samples of two the treatment of MPM. independent cohorts of 107 (cohort 1) and 46 (cohort 2) MPM http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

PI3K/mTOR Signaling in Mesothelioma Patients Treated with Induction Chemotherapy Followed by Extrapleural Pneumonectomy

Opitz, Isabelle
Journal of Thoracic Oncology , Volume 9 (2) – Feb 1, 2014
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References (52)

Copyright
Copyright © 2013 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
DOI
10.1097/JTO.0000000000000055
pmid
24419422
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE PI3K/mTOR Signaling in Mesothelioma Patients  Treated with Induction Chemotherapy Followed by  Extrapleural Pneumonectomy Byron K.Y. Bitanihirwe, PhD,* Mayura Meerang, PhD,* Martina Friess, VMD,* Alex Soltermann, MD,† Lukas Frischknecht, MD,† Svenja Thies, MD,† Emanuela Felley-Bosco, PhD,‡ Ming-Sound Tsao, MD,§ Ghassan Allo, MD,§ Marc de Perrot, MD,║ Burkhardt Seifert, PhD,¶ Holger Moch, MD,† Rolf Stahel MD,‡ Walter Weder MD,* and Isabelle Opitz, MD* expression in samples before and after induction chemotherapy of Introduction: The prognostic significance of activity biomarkers cohort 1 revealed that decreased cytoplasmic PTEN and increased within the phosphatidylinositol 3-kinase (PI3K)/mammalian target phospho-mTOR expression was associated with a worse OAS of rapamycin (mTOR) signaling pathway was assessed in two inde- (p = 0.04 and p = 0.03, respectively). pendent cohorts of malignant pleural mesothelioma (MPM) patients Conclusions: These novel data reveal a prognostic significance of uniformly treated with a multimodal approach. We specifically expression changes of PI3K/mTOR pathway components during assessed expression signatures in a unique set of pre- and postchemo- induction chemotherapy if confirmed in other patient cohorts and therapy tumor samples. support the growing evidence to target the PI3K/mTOR pathway in Methods: Biomarker expression was assessed in samples of two the treatment of MPM. independent cohorts of 107 (cohort 1) and 46 (cohort 2) MPM

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Feb 1, 2014

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