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February 2015 No. 290 Founded in 1966 by Professor D M Davies, FRCP, FRCP Ed ISSN 0044–6394 was only a slight rise. There was no correlation between the incidence of photosensitivity and Photosensitivity reactions and skin voriconazole serum concentrations in six children with allergic bronchopulmonary aspergillosis. tumours associated with voriconazole Voriconazole is not a chromophore, but it has metabolites, voriconazole-N-oxide, hydroxyvori- conazole, and dihydroxyvoriconazole, which are Jeffrey K. Aronson formed by the action of CYP2C19 and which Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health might be activated by ultraviolet light. The hy- Sciences, Oxford, UK pothesis that a metabolite may be responsible for Correspondence to Jeffrey K. Aronson, DPhil, FRCP, HonFBPhS, Centre for Evidence photosensitivity due to voriconazole was sup- Based Medicine, Nuffield Department of Primary Care Health Sciences, New Radcliffe ported by a case in which hepatotoxicity and a House, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. lichenoid skin eruption occurred during oral E-mail: jeffrey.aronson@phc.ox.ac.uk but not intravenous voriconazole therapy. In a retrospective study of 24 lung transplant recipi- ents with cystic fibrosis who took voriconazole, heterozygous carriers of the CYP2C192 allele Summary required lower maintenance doses than those with the wild-type
Adverse Drug Reaction Bulletin – Wolters Kluwer Health
Published: Feb 1, 2015
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